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M7824 in Patients With Metastatic Colorectal Cancer or With Advanced Solid Tumors With Microsatellite Instability

• Authors : National Cancer Institute (NCI)

• Source: A Phase Ib/II Trial of M7824 in Solid Tumors With Microsatellite Instability With Consensus Molecular Subtype 4 Metastatic Colorectal

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A Study of Nivolumab, Nivolumab Plus Ipilimumab, or Investigator's Choice Chemotherapy for the Treatment of Participants With Deficient Mismatch Repair (dMMR)/Microsatellite Instability High (MSI-H) Metastatic Colorectal Cancer (mCRC) (CheckMate 8HW)

• Authors : Ono Pharmaceutical Co. Ltd

• Source: A Phase 3 Randomized Clinical Trial of Nivolumab Alone, Nivolumab in Combination With Ipilimumab, or Investigator's Choice Chemotherapy in Participants With

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Study of HRO761 Alone or in Combination in Cancer Patients With Specific DNA Alterations Called Microsatellite Instability or Mismatch Repair Deficiency.

• Source: An Open-label, Multi-center Phase I/Ib Dose Finding and Expansion Study of HRO761 as Single Agent and in Combinations in Patients With Microsatellite

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IBI310 in Combination with Sintilimab in Patients with DNA Mismatch Repair Deficient (dMMR)/microsatellite Instability High (MSI-H) Locally-advanced or Metastatic Colorectal Cancer

• Source: An Open-label, Multicenter, Phase 2 Study of IBI310 in Combination with Sintilimab in Patients with DNA Mismatch Repair Deficient (dMMR) /microsatellite

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Analysis of Concordance Between Next-Generation Sequencing Assessment of Microsatellite Instability and Immunohistochemistry-Mismatch Repair From Solid Tumors.

• Authors : Ali-Fehmi, Rouba; Krause, Harris; Morris, Robert

Subjects: Humans; Microsatellite Instability; High-Throughput Nucleotide Sequencing

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A Study of Adjuvant Atezolizumab or Atezolizumab Plus Tiragolumab in Solid Tumors with Resectable Disease with Intermediate-High Risk of Recurrence and High Tumor Mutational Burden (TMB-H) or Microsatellite Instability (MSI-H) (IMperator)

• Source: A Phase II, Open Label, Randomized, Non-Comparative Cohorts Study of Adjuvant Atezolizumab or Atezolizumab Plus Tiragolumab in Solid Tumors with Resectable Disease with Intermediate-High Risk of

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Evaluation of Co-formulated Pembrolizumab/Quavonlimab (MK-1308A) Versus Other Treatments in Participants With Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Stage IV Colorectal Cancer (CRC) (MK-1308A-008/KEYSTEP-008)

• Source: A Phase 2, Multicenter, Multi Arm, Study to Evaluate MK-1308A (Co-formulated Quavonlimab (MK-1308)/Pembrolizumab) Versus Other Treatments in Participants With

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Different Cycles of Preoperative Neoadjuvant Sintilimab in Mismatch-repair Deficient/Microsatellite Instability-high, Locally Advanced Colorectal Cancer

• Authors : Yugui Lian, The First Affiliated Hospital of Zhengzhou University

• Source: Eight vs Four Cycles of Preoperative Neoadjuvant Sintilimab in Mismatch-repair Deficient/Microsatellite Instability-high, Locally Advanced

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Association of PD-L1 positivity with Epstein Barr virus infection and microsatellite instability in gastric carcinomas with lymphoid stroma.

• Authors : Lee SM; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 350 W. 11th street, Indianapolis, IN, 46202, USA. .; Department of Pathology, Jeju National University Hospital, Jeju-si, South Korea. .

Subjects: Stomach Neoplasms*/Stomach Neoplasms*/Stomach Neoplasms*/virology ; Stomach Neoplasms*/Stomach Neoplasms*/Stomach Neoplasms*/genetics ; Stomach Neoplasms*/Stomach Neoplasms*/Stomach Neoplasms*/pathology

• Source: Scientific reports [Sci Rep] 2024 Dec 28; Vol. 14 (1), pp. 30932. Date of Electronic Publication: 2024 Dec 28.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Iparomlimab (QL1604) in patients with microsatellite instability-high (MSI-H) or mismatch repair-deficient (dMMR) unresectable or metastatic solid tumors: a pivotal, single-arm, multicenter, phase II trial.

• Authors : Bi F; Division of Abdominal Cancer, Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China.; Dong J

Subjects: Microsatellite Instability* ; DNA Mismatch Repair* ; Neoplasms*/Neoplasms*/Neoplasms*/drug therapy

• Source: Journal of hematology & oncology [J Hematol Oncol] 2024 Nov 11; Vol. 17 (1), pp. 109. Date of Electronic Publication: 2024 Nov 11.Publisher: Biomed Central Country of Publication: England NLM ID: 101468937 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-8722

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