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Wild-type C-Raf gene dosage and dimerization drive prostate cancer metastasis

• Authors : Ta, Lisa; Tsai, Brandon L; Deng, Weixian

Subjects: Biochemistry and Cell Biology; Biomedical and Clinical Sciences; Oncology and Carcinogenesis

• Source: iScience. 26(12)

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1,3-Dichloroadamantyl-Containing Ureas as Potential Triple Inhibitors of Soluble Epoxide Hydrolase, p38 MAPK and c-Raf.

• Authors : Gladkikh, Boris P.¹ (AUTHOR) ; Danilov, Dmitry V.¹ (AUTHOR) ; D'yachenko, Vladimir S.^1,2 (AUTHOR)

Subjects: *EPOXIDE hydrolase; *MITOGEN-activated protein kinases; *INFLAMMATORY mediators

• Source: International Journal of Molecular Sciences. Jan2024, Vol. 25 Issue 1, p338. 29p.

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Disruption of the pro-oncogenic c-RAF–PDE8A complex represents a differentiated approach to treating KRAS–c-RAF dependent PDAC.

• Authors : Cooke, Sean F.¹ (AUTHOR); Wright, Thomas A.¹ (AUTHOR); Sin, Yuan Yan¹ (AUTHOR)

• Source: Scientific Reports. 4/18/2024, Vol. 14 Issue 1, p1-16. 16p.

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Disruption of the pro-oncogenic c-RAF–PDE8A complex represents a differentiated approach to treating KRAS–c-RAF dependent PDAC

• Authors : Sean F. Cooke; Thomas A. Wright; Yuan Yan Sin

Subjects: Pancreatic ductal adenocarcinoma; KRAS; c-RAF-PDE8A

• Source: Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)

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Therapeutic combinations comprising a c-RAF inhibitor

تفاصيل العنوان

1,3-Dichloroadamantyl-Containing Ureas as Potential Triple Inhibitors of Soluble Epoxide Hydrolase, p38 MAPK and c-Raf

• Authors : Boris P. Gladkikh; Dmitry V. Danilov; Vladimir S. D’yachenko

Subjects: soluble epoxide hydrolase (sEH); cancer; p38 MAPK

• Source: International Journal of Molecular Sciences, Vol 25, Iss 1, p 338 (2023)

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Discovery of New Quinolone-Based Diarylamides as Potent B-RAF V600E /C-RAF Kinase Inhibitors Endowed with Promising In Vitro Anticancer Activity.

• Authors : Kim, Hyun Ji¹ (AUTHOR); Park, Jung Woo² (AUTHOR); Seo, Sangjae² (AUTHOR)

Subjects: *KINASE inhibitors; *ANTINEOPLASTIC agents; *CELL lines

• Source: International Journal of Molecular Sciences. Feb2023, Vol. 24 Issue 4, p3216. 25p.

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Increased migration and motility in XIAP-null cells mediated by the C-RAF protein kinase.

• Authors : Russell LG; Newcastle University Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Davis LAK

Subjects: Lymphocytes, Null*/Lymphocytes, Null*/Lymphocytes, Null*/metabolism ; Proto-Oncogene Proteins c-raf*/Proto-Oncogene Proteins c-raf*/Proto-Oncogene Proteins c-raf*/metabolism; Apoptosis

• Source: Scientific reports [Sci Rep] 2022 May 13; Vol. 12 (1), pp. 7943. Date of Electronic Publication: 2022 May 13.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

تفاصيل العنوان

C-RAF Mutants that Confer Resistance to RAF Inhibitors

تفاصيل العنوان

Wild-type C-Raf gene dosage and dimerization drive prostate cancer metastasis

• Authors : Lisa Ta; Brandon L. Tsai; Weixian Deng

Subjects: Biochemistry; Molecular biology; Cancer

• Source: iScience, Vol 26, Iss 12, Pp 108480- (2023)

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