نتائج البحث

Novel quinazolin-4-one based derivatives bearing 1,2,3-triazole and glycoside moieties as potential cytotoxic agents through dual EGFR and VEGFR-2 inhibitory activity

• Authors : Adel A.-H. Abdel-Rahman; Mohamed N. El-Bayaa; Asmaa Sobhy

Subjects: Quinazolin-4-one; 1,2,3-Triazole; Glycosides

• Source: Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)

تفاصيل العنوان

Identification of Benzothiazoles Bearing 1,3,4-Thiadiazole as Antiproliferative Hybrids Targeting VEGFR-2 and BRAF Kinase: Design, Synthesis, BIO Evaluation and In Silico Study.

• Authors : Ewes, Wafaa A.¹ (AUTHOR) ; Tawfik, Samar S.¹ (AUTHOR) ; Almatary, Aya M.² (AUTHOR)

• Source: Molecules. Jul2024, Vol. 29 Issue 13, p1-20. 20p. 6 Diagrams, 4 Charts, 2 Graphs.

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New sulfonamide-based glycosides incorporated 1,2,3-triazole as cytotoxic agents through VEGFR-2 and carbonic anhydrase inhibitory activity

• Authors : Hebat-Allah S. Abbas; Eman S. Nossier; May A. El-Manawaty

Subjects: Sulfonamide-based; 1,2,3-Triazole; Copper

• Source: Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)

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Apatinib has anti-tumor effects and induces autophagy in lung cancer cells with high expression of VEGFR-2.

• Authors : Mingtao Liu¹ ; Hui Li¹

• Source: Iranian Journal of Basic Medical Sciences. Nov2024, Vol. 27 Issue 11, p1370-1379. 10p.

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Unveiling promising phytocompounds from Moringa oleifera as dual inhibitors of EGFR(T790M/C797S) and VEGFR-2 in non-small cell lung cancer through in silico screening, ADMET, dynamics simulation, and DFT analysis

• Authors : Md. Masudur Rahman Munna; Md. Touki Tahamid Tusar; Saima Sajnin Shanta

Subjects: EGFR; VEGFR-2; Molecular docking

• Source: Journal of Genetic Engineering and Biotechnology, Vol 22, Iss 3, Pp 100406- (2024)

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QSAR analysis of VEGFR-2 inhibitors based on machine learning, Topomer CoMFA and molecule docking

• Authors : Hao Ding; Fei Xing; Lin Zou

Subjects: VEGFR-2; Structure–activity relationship model; Machine learning

• Source: BMC Chemistry, Vol 18, Iss 1, Pp 1-17 (2024)

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Discovery of novel thiazolyl-pyrazolines as dual EGFR and VEGFR-2 inhibitors endowed with in vitro antitumor activity towards non-small lung cancer

• Authors : Abdelsalam, Esraa A; El-Hafeez, Amer Ali Abd; Eldehna, Wagdy M

Subjects: Medicinal and Biomolecular Chemistry; Chemical Sciences; Cancer

• Source: Journal of Enzyme Inhibition and Medicinal Chemistry. 37(1)

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桃红四物汤对缺糖缺氧大鼠脑微血管内皮细胞 VEGF、VEGFR-2、 Akt 基因及蛋白表达的作用机制研究.

• Authors : 郭少英¹; 闫建军¹; 李 媛¹

• Source: Progress in Modern Biomedicine. 2024, Issue 4, p636-640. 5p.

تفاصيل العنوان

In Silico Screening of 1,3,4-Thiadiazole Derivatives as Inhibitors of Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2)

• Authors : Steven M. Ewell; Hannah Burton; Bereket Mochona

Subjects: molecular docking; molecular dynamics simulation; virtual screening

• Source: Current Issues in Molecular Biology, Vol 46, Iss 10, Pp 11220-11235 (2024)

تفاصيل العنوان

Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors.

• Authors : Shaldam, Moataz A.¹ (AUTHOR); Almahli, Hadia² (AUTHOR); Angeli, Andrea³ (AUTHOR)

Subjects: *ANTINEOPLASTIC agents; *CARBONIC anhydrase inhibitors; *ISATIN

• Source: Journal of Enzyme Inhibition & Medicinal Chemistry. Dec2023, Vol. 38 Issue 1, p1-12. 12p.

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