نتائج البحث

Neutron diffraction from a microgravity-grown crystal reveals the active site hydrogens of the internal aldimine form of tryptophan synthase

• Authors : Drago, Victoria N.; Devos, Juliette M.; Blakeley, Matthew P.

Subjects: enzyme mechanism; fold-type II; macromolecular crystallography

• Source: Cell Reports Physical Science. 5(2)

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Imaging active site chemistry and protonation states: NMR crystallography of the tryptophan synthase α-aminoacrylate intermediate

• Authors : Holmes, Jacob B; Liu, Viktoriia; Caulkins, Bethany G

Subjects: Biochemistry and Cell Biology; Inorganic Chemistry; Chemical Sciences

• Source: Proceedings of the National Academy of Sciences of the United States of America. 119(2)

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Estimating conformational heterogeneity of tryptophan synthase with a template-based Alphafold2 approach.

• Authors : Casadevall G; CompBioLab Group, Institut de Química Computacional i Catàlisi and Departament de Química, Universitat de Girona, Girona, Spain.; Duran C

Subjects: Tryptophan Synthase*/Tryptophan Synthase*/Tryptophan Synthase*/chemistry; Catalysis ; Catalytic Domain

• Source: Protein science : a publication of the Protein Society [Protein Sci] 2022 Oct; Vol. 31 (10), pp. e4426.Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9211750 Publication Model: Print Cited Medium: Internet

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Backbone assignments and conformational dynamics in the S. typhimurium tryptophan synthase α-subunit from solution-state NMR.

• Authors : Sakhrani, Varun V; Hilario, Eduardo; Caulkins, Bethany G

Subjects: Salmonella typhimurium; Nitrogen Isotopes; Tryptophan Synthase

• Source: Journal of biomolecular NMR. 74(6-7)

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PCR Mutagenesis, Cloning, Expression, Fast Protein Purification Protocols and Crystallization of the Wild Type and Mutant Forms of Tryptophan Synthase.

• Authors : Hilario, Eduardo; Fan, Li; Mueller, Leonard J

Subjects: Biochemistry and Cell Biology; Biological Sciences; Infectious Diseases

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ENGINEERED BETA-SUBUNIT OF TRYPTOPHAN SYNTHASE FOR PRODUCTION OF NON-CANONICAL AMINO ACIDS

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Tailoring Tryptophan Synthase TrpB for Selective Quaternary Carbon Bond Formation

• Authors : Dick, Markus; Sarai, Nicholas S; Martynowycz, Michael W

Subjects: Prevention; Alkylation; Carbon

• Source: Journal of the American Chemical Society. 141(50)

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Identification of new benzamide inhibitor against α-subunit of tryptophan synthase from Mycobacterium tuberculosis through structure-based virtual screening, anti-tuberculosis activity and molecular dynamics simulations

• Authors : Naz, Sadia; Farooq, Umar; Ali, Sajid

Subjects: Biochemistry and Cell Biology; Biological Sciences; Tuberculosis

• Source: Journal of Biomolecular Structure and Dynamics. 37(4)

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Discovery of antimicrobial agent targeting tryptophan synthase.

• Authors : Bosken YK; Department of Chemistry, University of California at Riverside, Riverside, California.; Ai R

Subjects: Anti-Bacterial Agents*/Anti-Bacterial Agents*/Anti-Bacterial Agents*/chemistry ; Anti-Bacterial Agents*/Anti-Bacterial Agents*/Anti-Bacterial Agents*/pharmacology ; Tryptophan Synthase*/Tryptophan Synthase*/Tryptophan Synthase*/antagonists & inhibitors

• Source: Protein science : a publication of the Protein Society [Protein Sci] 2022 Feb; Vol. 31 (2), pp. 432-442. Date of Electronic Publication: 2021 Nov 26.Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9211750 Publication Model: Print-Electronic Cited Medium:

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Clinical Persistence of Chlamydia trachomatis Sexually Transmitted Strains Involves Novel Mutations in the Functional αββα Tetramer of the Tryptophan Synthase Operon

• Authors : Somboonna, Naraporn; Ziklo, Noa; Ferrin, Thomas E

Subjects: Vaccine Related; Infectious Diseases; Prevention

• Source: mBio. 10(4)

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