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  • 1-10 ل  3,239 نتائج ل ""Trypanocidal Agents""

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Academic Journal

Molecular Docking-Based Virtual Screening of FDA-Approved Drugs Using Trypanothione Reductase Identified New Trypanocidal Agents.

  • Authors : Gómez-Escobedo R; Departamento de Parasitología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México 07738, Mexico.; Méndez-Álvarez D

Subjects: Trypanocidal Agents*/Trypanocidal Agents*/Trypanocidal Agents*/pharmacology ; Trypanocidal Agents*/Trypanocidal Agents*/Trypanocidal Agents*/chemistry ; NADH, NADPH Oxidoreductases*/NADH, NADPH Oxidoreductases*/NADH, NADPH Oxidoreductases*/antagonists & inhibitors

  • Source: Molecules (Basel, Switzerland) [Molecules] 2024 Aug 10; Vol. 29 (16). Date of Electronic Publication: 2024 Aug 10.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

Redefining the treatment of Chagas disease: a review of recent clinical and pharmacological data for a novel formulation of nifurtimox.

  • Authors : Altcheh J; Hospital de Niños Ricardo Gutiérrez and Instituto Multidisciplinario de Investigacion en Patologias Pediatricas (IMIPP), CONICET-GCBA, Buenos Aires, Argentina.; Grossmann U

Subjects: Chagas Disease*/Chagas Disease*/Chagas Disease*/drug therapy ; Nifurtimox*/Nifurtimox*/Nifurtimox*/therapeutic use ; Nifurtimox*/Nifurtimox*/Nifurtimox*/administration & dosage

  • Source: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2025 Feb 25; Vol. 19 (2), pp. e0012849. Date of Electronic Publication: 2025 Feb 25 (Print Publication: 2025).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Longitudinal observational (single cohort) study on the causes of trypanocide failure in cases of African animal trypanosomosis in cattle near wildlife protected areas of Northern Tanzania.

  • Authors : Richards S; International Livestock Research Institute, Nairobi, Kenya.; School of Biodiversity, One Health and Veterinary Medicine, University of Glasgow, Glasgow, Scotland, United Kingdom.

Subjects: Trypanocidal Agents*/Trypanocidal Agents*/Trypanocidal Agents*/administration & dosage ; Trypanocidal Agents*/Trypanocidal Agents*/Trypanocidal Agents*/therapeutic use; Animals

  • Source: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2025 Jan 21; Vol. 19 (1), pp. e0012541. Date of Electronic Publication: 2025 Jan 21 (Print Publication: 2025).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

In vitro assays identified thiohydantoins with anti-trypanosomatid activity and molecular modelling studies indicated possible selective CYP51 inhibition.

  • Authors : Camargo PG; Departamento de Química, Centro de Ciências Exatas, Universidade Estadual de Londrina, Londrina, PR, Brasil.; Faculdade de Farmácia, Departamento de Fármacos e Medicamentos, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

Subjects: Trypanosoma cruzi*/Trypanosoma cruzi*/Trypanosoma cruzi*/drug effects ; Trypanosoma cruzi*/Trypanosoma cruzi*/Trypanosoma cruzi*/enzymology ; Molecular Docking Simulation*

  • Source: Scientific reports [Sci Rep] 2025 Jan 02; Vol. 15 (1), pp. 465. Date of Electronic Publication: 2025 Jan 02.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Transcriptomic analysis of benznidazole-resistant Trypanosoma cruzi clone reveals nitroreductase I-independent resistance mechanisms.

  • Authors : Mejía-Jaramillo AM; Grupo Biología y Control de Enfermedades Infecciosas, BCEI, Universidad de Antioquia, UdeA, Medellín, Colombia, South America.; Ospina-Zapata H

Subjects: Trypanosoma cruzi*/Trypanosoma cruzi*/Trypanosoma cruzi*/genetics ; Trypanosoma cruzi*/Trypanosoma cruzi*/Trypanosoma cruzi*/drug effects ; Nitroimidazoles*/Nitroimidazoles*/Nitroimidazoles*/pharmacology

  • Source: PloS one [PLoS One] 2025 Feb 18; Vol. 20 (2), pp. e0314189. Date of Electronic Publication: 2025 Feb 18 (Print Publication: 2025).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Ligand-Based Virtual Screening and Molecular Docking of Benzimidazoles as Potential Inhibitors of Triosephosphate Isomerase Identified New Trypanocidal Agents.

  • Authors : Vázquez-Jiménez LK; Laboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa 88710, Mexico.; Juárez-Saldivar A

Subjects: Trypanocidal Agents*/Trypanocidal Agents*/Trypanocidal Agents*/chemistry ; Trypanocidal Agents*/Trypanocidal Agents*/Trypanocidal Agents*/pharmacology ; Trypanosoma cruzi*/Trypanosoma cruzi*/Trypanosoma cruzi*/metabolism

  • Source: International journal of molecular sciences [Int J Mol Sci] 2022 Sep 02; Vol. 23 (17). Date of Electronic Publication: 2022 Sep 02.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Potential Trypanocidal Activity of Glycerol Analogues.

  • Authors : Humann RA; BSRC, School of Biology, University of St Andrews, St Andrews, KY16 9AJ, UK.; Smith TK

Subjects: Glycerol*/Glycerol*/Glycerol*/chemistry ; Glycerol*/Glycerol*/Glycerol*/pharmacology ; Trypanosoma brucei brucei*/Trypanosoma brucei brucei*/Trypanosoma brucei brucei*/drug effects

  • Source: ChemistryOpen [ChemistryOpen] 2024 Dec; Vol. 13 (12), pp. e202400094. Date of Electronic Publication: 2024 Sep 12.Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 101594811 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Increased Trypanocidal Activity of the Salinomycin Derivative Ironomycin Is Due to ROS Production and Iron Uptake Impairment.

  • Authors : Steverding D; Bob Champion Research and Education Building, Norwich Medical School, University of East Anglia, Norwich NR4 7UQ, UK.; Rushworth SA

Subjects: Pyrans*/Pyrans*/Pyrans*/pharmacology ; Pyrans*/Pyrans*/Pyrans*/chemistry ; Reactive Oxygen Species*/Reactive Oxygen Species*/Reactive Oxygen Species*/metabolism

  • Source: Molecules (Basel, Switzerland) [Molecules] 2024 Nov 27; Vol. 29 (23). Date of Electronic Publication: 2024 Nov 27.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

Evaluation of the antitrypanosomal activity, cytotoxicity and phytochemistry of red Brazilian propolis.

  • Authors : Alanazi S; Clinical Laboratory Sciences Department, College of Applied Medical Sciences, King Saud University, Riyad, Saudi Arabia.; Alenzi ND

Subjects: Propolis*/Propolis*/Propolis*/chemistry ; Propolis*/Propolis*/Propolis*/pharmacology ; Trypanosoma brucei brucei*/Trypanosoma brucei brucei*/Trypanosoma brucei brucei*/drug effects

  • Source: PloS one [PLoS One] 2024 Nov 19; Vol. 19 (11), pp. e0313987. Date of Electronic Publication: 2024 Nov 19 (Print Publication: 2024).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

In Vitro Evaluation of New 5-Nitroindazolin-3-one Derivatives as Promising Agents against Trypanosoma cruzi .

  • Authors : Pozo-Martínez J; Department of Molecular Pharmacology and Clinical, Faculty of Medicine, University of Chile, Santiago 8380453, Chile.; Laboratorio de Química-Médica, Facultad de Ciencia y Tecnología, Universidad del Azuay, Av. 24 de Mayo 777, Cuenca 010204, Ecuador.

Subjects: Trypanosoma cruzi*/Trypanosoma cruzi*/Trypanosoma cruzi*/drug effects ; Trypanocidal Agents*/Trypanocidal Agents*/Trypanocidal Agents*/pharmacology ; Trypanocidal Agents*/Trypanocidal Agents*/Trypanocidal Agents*/chemistry

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 Oct 16; Vol. 25 (20). Date of Electronic Publication: 2024 Oct 16.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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  • 1-10 ل  3,239 نتائج ل ""Trypanocidal Agents""