نتائج البحث

Transient receptor potential vanilloid 4 blockage attenuates pyroptosis in hippocampus of mice following pilocarpine‑induced status epilepticus.

• Authors : Liu L; Department of Physiology, Nanjing Medical University, No. 101, Longmian Ave, Nanjing, Jiangsu Province, 211166, P.R. China.; Wang Y

Subjects: TRPV Cation Channels*/TRPV Cation Channels*/TRPV Cation Channels*/antagonists & inhibitors ; TRPV Cation Channels*/TRPV Cation Channels*/TRPV Cation Channels*/metabolism ; Hippocampus*/Hippocampus*/Hippocampus*/drug effects

• Source: Acta neuropathologica communications [Acta Neuropathol Commun] 2025 Apr 10; Vol. 13 (1), pp. 73. Date of Electronic Publication: 2025 Apr 10.Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960

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Febrile temperature-regulated TRPV1 in CD4 + T cells mediates neuroinflammation in complex febrile seizures.

• Authors : Kong S; Department of Physiology, Wuhan University School of Basic Medical Sciences, 185 Donghu Road, Wuhan, 430071, Hubei, China.; Jia X

Subjects: TRPV Cation Channels*/TRPV Cation Channels*/TRPV Cation Channels*/metabolism ; TRPV Cation Channels*/TRPV Cation Channels*/TRPV Cation Channels*/genetics ; Seizures, Febrile*/Seizures, Febrile*/Seizures, Febrile*/metabolism

• Source: Journal of neuroinflammation [J Neuroinflammation] 2025 Apr 07; Vol. 22 (1), pp. 103. Date of Electronic Publication: 2025 Apr 07.Publisher: BioMed Central Country of Publication: England NLM ID: 101222974 Publication Model: Electronic Cited Medium: Internet ISSN: 1742-2094

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Genetic editing of primary human dorsal root ganglion neurons using CRISPR-Cas9.

• Authors : Palomino SM; Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center, 6202 Harry Hines Blvd., 9th Floor, Dallas, 75235, TX, USA.; Gabriel KA

Subjects: Gene Editing*/Gene Editing*/Gene Editing*/methods ; CRISPR-Cas Systems* ; Ganglia, Spinal*/Ganglia, Spinal*/Ganglia, Spinal*/metabolism

• Source: Scientific reports [Sci Rep] 2025 Apr 01; Vol. 15 (1), pp. 11116. Date of Electronic Publication: 2025 Apr 01.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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TRPV4 drives the progression of leiomyosarcoma by promoting ECM1 generation and co-activating the FAK/PI3K/AKT/GSK3β pathway.

• Authors : Zhou Q; Department of Oncology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.; You Y

Subjects: TRPV Cation Channels*/TRPV Cation Channels*/TRPV Cation Channels*/metabolism ; TRPV Cation Channels*/TRPV Cation Channels*/TRPV Cation Channels*/genetics ; Proto-Oncogene Proteins c-akt*/Proto-Oncogene Proteins c-akt*/Proto-Oncogene Proteins c-akt*/metabolism

• Source: Cellular oncology (Dordrecht, Netherlands) [Cell Oncol (Dordr)] 2025 Apr; Vol. 48 (2), pp. 455-470. Date of Electronic Publication: 2024 Nov 29.Publisher: Springer Country of Publication: Netherlands NLM ID: 101552938 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Extracellular osmolarity regulates osteoblast migration through the TRPV4-Rho/ROCK signaling.

• Authors : Li Y; Department of Rehabilitation Medicine, Peking University Third Hospital, 49 North Garden Road, Beijing, 100191, China.; Yang Y

Subjects: Osteoblasts*/Osteoblasts*/Osteoblasts*/metabolism ; TRPV Cation Channels*/TRPV Cation Channels*/TRPV Cation Channels*/metabolism ; TRPV Cation Channels*/TRPV Cation Channels*/TRPV Cation Channels*/genetics

• Source: Communications biology [Commun Biol] 2025 Mar 29; Vol. 8 (1), pp. 515. Date of Electronic Publication: 2025 Mar 29.Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN:

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Expression, Distribution and Function of the Transient Receptor Potential Vanilloid Type 1 (TRPV1) in Endometrial Cancer.

• Authors : Ayakannu T; Endocannabinoid Research Group, Reproductive Sciences Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester LE1 7RH, UK.; Obstetrics & Gynaecology Centre of Excellence, Sunway Medical Centre, Petaling Jaya 47500, Malaysia.

Subjects: TRPV Cation Channels*/TRPV Cation Channels*/TRPV Cation Channels*/genetics ; TRPV Cation Channels*/TRPV Cation Channels*/TRPV Cation Channels*/metabolism ; Endometrial Neoplasms*/Endometrial Neoplasms*/Endometrial Neoplasms*/metabolism

• Source: International journal of molecular sciences [Int J Mol Sci] 2025 Mar 27; Vol. 26 (7). Date of Electronic Publication: 2025 Mar 27.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Discovery of TRPV4-Targeting Small Molecules with Anti-Influenza Effects Through Machine Learning and Experimental Validation.

• Authors : Sun Y; College of Veterinary Medicine, Shanxi Agricultural University, Jinzhong 030801, China.; State Key Laboratory of Pathogen and Biosecurity, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China.

Subjects: TRPV Cation Channels*/TRPV Cation Channels*/TRPV Cation Channels*/metabolism ; TRPV Cation Channels*/TRPV Cation Channels*/TRPV Cation Channels*/antagonists & inhibitors ; Antiviral Agents*/Antiviral Agents*/Antiviral Agents*/pharmacology

• Source: International journal of molecular sciences [Int J Mol Sci] 2025 Feb 06; Vol. 26 (3). Date of Electronic Publication: 2025 Feb 06.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Indole-2-Carboxamide as an Effective Scaffold for the Design of New TRPV1 Agonists.

• Authors : Maramai S; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.; Mugnaini C

Subjects: TRPV Cation Channels*/TRPV Cation Channels*/TRPV Cation Channels*/agonists ; TRPV Cation Channels*/TRPV Cation Channels*/TRPV Cation Channels*/metabolism ; Indoles*/Indoles*/Indoles*/chemistry

• Source: Molecules (Basel, Switzerland) [Molecules] 2025 Feb 05; Vol. 30 (3). Date of Electronic Publication: 2025 Feb 05.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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The Impact of a Quinone Scaffold on Thermo-TRPs Modulation by Dimethylheptyl Phytocannabinoids.

• Authors : Schiano Moriello, Aniello^1,2 (AUTHOR); Bossoni, Aurora^2,3 (AUTHOR); Mattoteia, Daiana³ (AUTHOR)

Subjects: *CANNABIS (Genus); *CANNABINOIDS; *MOLECULAR docking

• Source: International Journal of Molecular Sciences. Mar2025, Vol. 26 Issue 6, p2682. 14p.

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Biochemical Mechanisms That Buffer the Effects of High Temperatures in the Sand-Dwelling Lizard Holbrookia propinqua.

• Authors : Caballero Vázquez, Yessica¹ (AUTHOR); Rodríguez-Tobón, Ahiezer² (AUTHOR); Méndez de la Cruz, Fausto Roberto³ (AUTHOR)

• Source: Animals (2076-2615). Mar2025, Vol. 15 Issue 5, p656. 17p.

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