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Discovery of a novel piperazine derivative, cmp2: a selective TRPC6 activator suitable for treatment of synaptic deficiency in Alzheimer's disease hippocampal neurons.

• Authors : Zernov N; Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg Polytechnic University, St. Petersburg, 195251, Russia.; Ghamaryan V

Subjects: Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/drug therapy ; Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/metabolism ; Hippocampus*/Hippocampus*/Hippocampus*/metabolism

• Source: Scientific reports [Sci Rep] 2024 Oct 09; Vol. 14 (1), pp. 23512. Date of Electronic Publication: 2024 Oct 09.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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TRPC6 is a Biomarker for Prognosis and Immunotherapy of Stomach Adenocarcinoma Based on Bioinformatic Analysis and Experimental Validation

• Authors : Hu X; Wang H; Sun H

Subjects: trpc6; stomach adenocarcinoma; immunotherapy

• Source: ImmunoTargets and Therapy, Vol Volume 13, Pp 735-748 (2024)

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CaR调节 TRPC6介导的自噬对软骨细胞 SOD及 NOX2的影响.

• Authors : 秦星星¹ ; 占承志¹; 陈 俊¹

• Source: Journal of Modern Medicine & Health. 12/15/2024, Vol. 40 Issue 23, p3961-3966. 6p.

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Discovery of a novel piperazine derivative, cmp2: a selective TRPC6 activator suitable for treatment of synaptic deficiency in Alzheimer’s disease hippocampal neurons

• Authors : Nikita Zernov; Viktor Ghamaryan; Daria Melenteva

Subjects: TRPC6; Alzheimer’s disease; Piperazine

• Source: Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)

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Pharmacological Activation of TRPC6 Channel Prevents Colitis Progression.

• Authors : Nishiyama K; Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.; Laboratory of Prophylactic Pharmacology, Osaka Metropolitan University Graduate School of Veterinary Science, Osaka 598-8531, Japan.

Subjects: Inflammatory Bowel Diseases*/Inflammatory Bowel Diseases*/Inflammatory Bowel Diseases*/drug therapy ; Inflammatory Bowel Diseases*/Inflammatory Bowel Diseases*/Inflammatory Bowel Diseases*/metabolism ; TRPC6 Cation Channel*/TRPC6 Cation Channel*/TRPC6 Cation Channel*/genetics

• Source: International journal of molecular sciences [Int J Mol Sci] 2024 Feb 18; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 18.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Renal ischaemia-reperfusion injury is promoted by transcription factor NF-kB p65, which inhibits TRPC6 expression by activating miR-150.

• Authors : Li S; Department of Nephrology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang, China.; Ma Q

Subjects: MicroRNAs*/MicroRNAs*/MicroRNAs*/genetics ; MicroRNAs*/MicroRNAs*/MicroRNAs*/metabolism ; Reperfusion Injury*/Reperfusion Injury*/Reperfusion Injury*/genetics

• Source: Clinical hemorheology and microcirculation [Clin Hemorheol Microcirc] 2024; Vol. 86 (3), pp. 369-382.Publisher: Ios Press Country of Publication: Netherlands NLM ID: 9709206 Publication Model: Print Cited Medium: Internet ISSN: 1875-8622

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TRPC6 Characterization to Predict and Prevent Chemotherapy Related Cardiomyopathy and Heart Failure With Breast Cancer

• Source: Characterization of TRPC6 to Predict and Prevent Chemotherapy Related Cardiomyopathy and Heart Failure (Prospective Study)

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Salvianolic Acid B Inhibits Myocardial Fibrosis during Diabetic Cardiomyopathy via Suppressing TRPC6 and TGF‐β/Smad3 Pathway.

• Authors : Lu, Pengyu^1,2 (AUTHOR); Zhang, Meng^1,2 (AUTHOR); Chen, Zhaoyang^1,2 (AUTHOR)

Subjects: *TRP channels; *TRANSFORMING growth factors; *CARDIAC hypertrophy

• Source: Journal of Food Biochemistry. 9/27/2024, Vol. 2024, p1-18. 18p.

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TRPV4 Channels Promote Pathological, but Not Physiological, Cardiac Remodeling through the Activation of Calcineurin/NFAT and TRPC6.

• Authors : Yáñez-Bisbe, Laia¹ (AUTHOR) ; Moya, Mar¹ (AUTHOR) ; Rodríguez-Sinovas, Antonio^1,2 (AUTHOR)

Subjects: *TRPV cation channels; *CALCINEURIN; *PROTEIN analysis

• Source: International Journal of Molecular Sciences. Feb2024, Vol. 25 Issue 3, p1541. 20p.

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TRPC6 Deletion Enhances eNOS Expression and Reduces LPS—Induced Acute Lung Injury.

• Authors : Wang, Mengyuan^1,2 (AUTHOR) ; Zhang, Xingfang² (AUTHOR); Guo, Juan¹ (AUTHOR)

Subjects: *TRP channels; *GENE expression; *LUNG injuries

• Source: International Journal of Molecular Sciences. Dec2023, Vol. 24 Issue 23, p16756. 15p.

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