نتائج البحث

Mutation of the TGN1412 anti‐CD28 monoclonal antibody lower hinge confers specific FcγRIIb binding and retention of super‐agonist activity

• Authors : Chenoweth, Alicia M; Esparon, Sandra; Wines, Bruce D ...

• Source: Immunology & Cell Biology ; volume 101, issue 7, page 657-662 ; ISSN 0818-9641 1440-1711

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The rise and fall of the CD28 superagonist TGN1412 and its return as TAB08: a personal account.

• Authors : Hünig, Thomas¹

Subjects: *CD28 antigen; *MONOCLONAL antibodies; *T cells

• Source: FEBS Journal. Sep2016, Vol. 283 Issue 18, p3325-3334. 10p.

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Were monocytes responsible for initiating the cytokine storm in the TGN1412 clinical trial tragedy? G. P. Sandilands et al. TGN1412 clinical trial.

• Authors : Sandilands, G. P.¹ ; Wilson, M.¹; Huser, C.¹

Subjects: *MONOCYTES; *CYTOKINES; *CLINICAL trials

• Source: Clinical & Experimental Immunology. Dec2010, Vol. 162 Issue 3, p516-527. 12p. 2 Color Photographs, 1 Diagram, 3 Charts, 3 Graphs.

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After TGN1412: Recent developments in cytokine release assays.

• Authors : Stebbings, R.¹ (AUTHOR) ; Eastwood, D.¹ (AUTHOR); Poole, S.¹ (AUTHOR)

• Source: Journal of Immunotoxicology. Jan-Mar2013, Vol. 10 Issue 1, p75-82. 8p. 1 Color Photograph, 4 Graphs.

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TGN1412 Induces Lymphopenia and Human Cytokine Release in a Humanized Mouse Model.

• Authors : Weißmüller, Sabrina¹; Kronhart, Stefanie¹; Kreuz, Dorothea²

Subjects: *LYMPHOPENIA; *CYTOKINES; *LABORATORY mice

• Source: PLoS ONE. 3/9/2016, Vol. 11 Issue 3, p1-19. 19p.

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TGN1412 Induces Lymphopenia and Human Cytokine Release in a Humanized Mouse Model.

• Authors : Sabrina Weißmüller; Stefanie Kronhart; Dorothea Kreuz

Subjects: Medicine; Science

• Source: PLoS ONE, Vol 11, Iss 3, p e0149093 (2016)

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A predictive biomimetic model of cytokine release induced by TGN1412 and other therapeutic monoclonal antibodies.

• Authors : Dhir, Vipra¹ (AUTHOR); Fort, Madeline² (AUTHOR); Mahmood, Ayesha¹ (AUTHOR)

• Source: Journal of Immunotoxicology. Mar2012, Vol. 9 Issue 1, p34-42. 9p.

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TGN1412: From Discovery to Disaster.

• Authors : Attarwala, H.¹

• Source: Journal of Young Pharmacists. 2010, Vol. 2 Issue 3, p332-336. 5p. 1 Chart.

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Establishing risk of human experimentation with drugs: lessons from TGN1412.

• Authors : Kenter, MJH¹; Cohen, AF^1,2

• Source: Lancet. 10/14/2006, Vol. 368 Issue 9544, p1387-1391. 5p. 2 Diagrams, 1 Chart.

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Human Fcγ receptors compete for TGN1412 binding that determines the antibody's effector function

• Authors : Dudek, Simone; Weißmüller, Sabrina; Anzaghe, Martina

• Source: European Journal of Immunology ; volume 49, issue 7, page 1117-1126 ; ISSN 0014-2980 1521-4141

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