نتائج البحث

Screening of Small-Molecule Libraries Using SARS-CoV-2-Derived Sequences Identifies Novel Furin Inhibitors.

• Authors : Jorkesh A; Department of Pharmaceutical and Pharmacological Science, University of Padova, Via Marzolo, 5, 35131 Padova, Italy.; Department of Biology, University of Padua, Viale G. Colombo 3, 35131 Padova, Italy.

Subjects: Furin*/Furin*/Furin*/antagonists & inhibitors ; Furin*/Furin*/Furin*/metabolism ; SARS-CoV-2*/SARS-CoV-2*/SARS-CoV-2*/drug effects SARS-CoV-2 variants

• Source: International journal of molecular sciences [Int J Mol Sci] 2024 May 07; Vol. 25 (10). Date of Electronic Publication: 2024 May 07.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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A Novel Algorithm for the Virtual Screening of Extensive Small Molecule Libraries Against ERCC1/XPF Protein-Protein Interaction for the Identification of Therapeutic Resistance-Bypassing Small Anticancer Molecules.

• Authors : Ghazy, Salma^1,2; Oktay, Lalehan^1,2; Durdagi, Serdar^1,2,3

• Source: Turkish Journal of Biology. 2024, Vol. 48 Issue 2, p91-111. 22p.

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Binding and sensing diverse small molecules using shape-complementary pseudocycles.

• Authors : An L; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.

Subjects: Deep Learning* ; Protein Binding* ; Proteins*/Proteins*/Proteins*/chemistry

• Source: Science (New York, N.Y.) [Science] 2024 Jul 19; Vol. 385 (6706), pp. 276-282. Date of Electronic Publication: 2024 Jul 18.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic

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ChemoDOTS: a web server to design chemistry-driven focused libraries.

• Authors : Hoffer L; CRCM, CNRS, Inserm, Institut Paoli-Calmettes, Aix-Marseille Univ, Marseille 13273, France.; Charifi-Hoareau G

Subjects: Software* ; Internet* ; Small Molecule Libraries*/Small Molecule Libraries*/Small Molecule Libraries*/chemistry

• Source: Nucleic acids research [Nucleic Acids Res] 2024 Jul 05; Vol. 52 (W1), pp. W461-W468.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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Highly pure DNA-encoded chemical libraries by dual-linker solid-phase synthesis.

• Authors : Keller M; Department of Chemistry and Applied Biosciences, ETH Zurich, 8093 Zurich, Switzerland.; Petrov D

Subjects: DNA*/DNA*/DNA*/chemistry ; Drug Discovery*/Drug Discovery*/Drug Discovery*/methods ; Small Molecule Libraries*/Small Molecule Libraries*/Small Molecule Libraries*/chemistry

• Source: Science (New York, N.Y.) [Science] 2024 Jun 14; Vol. 384 (6701), pp. 1259-1265. Date of Electronic Publication: 2024 Jun 13.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic

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Reversible male contraception by targeted inhibition of serine/threonine kinase 33.

• Authors : Ku AF; Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USA.; Sharma KL

Subjects: Contraceptive Agents, Male*/Contraceptive Agents, Male*/Contraceptive Agents, Male*/chemistry ; Contraceptive Agents, Male*/Contraceptive Agents, Male*/Contraceptive Agents, Male*/pharmacology ; Protein Kinase Inhibitors*/Protein Kinase Inhibitors*/Protein Kinase Inhibitors*/pharmacology

• Source: Science (New York, N.Y.) [Science] 2024 May 24; Vol. 384 (6698), pp. 885-890. Date of Electronic Publication: 2024 May 23.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic

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Small molecule inhibitors targeting m 6 A regulators.

• Authors : Feng G; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, Innovation Center of Nursing Research, Nursing Key Laboratory of Sichuan Province, National Clinical Research Center for Geriatrics, West China Hospital, and West China Second Hospital, Sichuan University /West China School of Nursing, Sichuan University, Chengdu, 610041, China.; Wu Y

Subjects: Adenosine*/Adenosine*/Adenosine*/analogs & derivatives ; Adenosine*/Adenosine*/Adenosine*/metabolism ; Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/therapeutic use

• Source: Journal of hematology & oncology [J Hematol Oncol] 2024 May 06; Vol. 17 (1), pp. 30. Date of Electronic Publication: 2024 May 06.Publisher: Biomed Central Country of Publication: England NLM ID: 101468937 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-8722

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Virtual Screening of Small Molecules Targeting BCL2 with Machine Learning, Molecular Docking, and MD Simulation.

• Authors : Tondar A; Department of Computer Science, Multimedia and Telecommunication, Universitat Oberta de Catalunya (UOC), 08018 Barcelona, Spain.; Stanford Deep Data Research Center, Department of Genetics, Stanford University, Stanford, CA 94305, USA.

Subjects: Molecular Docking Simulation* ; Proto-Oncogene Proteins c-bcl-2*/Proto-Oncogene Proteins c-bcl-2*/Proto-Oncogene Proteins c-bcl-2*/chemistry ; Proto-Oncogene Proteins c-bcl-2*/Proto-Oncogene Proteins c-bcl-2*/Proto-Oncogene Proteins c-bcl-2*/antagonists & inhibitors

• Source: Biomolecules [Biomolecules] 2024 May 01; Vol. 14 (5). Date of Electronic Publication: 2024 May 01.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X

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Scaffold Hopping and Screening for Potent Small Molecule Agonists for GRP94: Implications to Alleviate ER Stress-Associated Pathogenesis.

• Authors : Mubarak SJ; Department of Bioinformatics, Bharathiar University, Coimbatore, Tamil Nadu, India.; Gupta S

Subjects: Endoplasmic Reticulum Stress*/Endoplasmic Reticulum Stress*/Endoplasmic Reticulum Stress*/drug effects ; Small Molecule Libraries*/Small Molecule Libraries*/Small Molecule Libraries*/pharmacology ; Small Molecule Libraries*/Small Molecule Libraries*/Small Molecule Libraries*/chemistry

• Source: Molecular biotechnology [Mol Biotechnol] 2024 Apr; Vol. 66 (4), pp. 737-755. Date of Electronic Publication: 2023 Feb 10.Publisher: Springer Country of Publication: Switzerland NLM ID: 9423533 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells.

• Authors : Offensperger F; CeMM, Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.; Tin G

Subjects: Drug Discovery* ; Machine Learning* ; Proteomics*/Proteomics*/Proteomics*/methods

• Source: Science (New York, N.Y.) [Science] 2024 Apr 26; Vol. 384 (6694), pp. eadk5864. Date of Electronic Publication: 2024 Apr 26.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic

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