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Activation of Cytosolic Cathepsin B Activity in the Brain by Traumatic Brain Injury and Inhibition by the Neutral pH Selective Inhibitor Probe Z-Arg-Lys-AOMK.

• Authors : Podvin, Sonia; Florio, Jazmin; Spencer, Brian

Subjects: brain lesion; cathepsin B; cytosol

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A First-in-human Study of PARP1 Selective Inhibitor, IMP1734, in Participants With Advanced Solid Tumors

• Authors : Impact Therapeutics, Inc.

• Source: A First-in-human, Phase 1/2, Open-label, Multi-center, Dose-escalation, Dose-optimization, and Dose-expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and

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A structure-based framework for selective inhibitor design and optimization.

• Authors : Zou, Yurong¹ (AUTHOR); Guo, Tao¹ (AUTHOR); Fu, Zhiyuan¹ (AUTHOR)

• Source: Communications Biology. 3/12/2025, Vol. 8 Issue 1, p1-15. 15p.

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PI3Kβ Selective Inhibitor With Paclitaxel, Advanced Gastric Adenocarcinoma

• Authors : Sun Young Rha, Professor

• Source: A Phase Ib/IIa, Open-Label, Dose Finding Study to Evaluate the Safety, Pharmacokinetics and Clinical Activity of PI3Kβ Selective

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Phase I Trial of the Selective Inhibitor of Nuclear Export, KPT-330, in Relapsed Childhood ALL and AML

• Authors : William Lawrence and Blanche Hughes Foundation; Karyopharm Therapeutics Inc; Andrew E. Place, MD, Principal Investigator

• Source: Phase I Trial of the Selective Inhibitor of Nuclear Export, KPT-330, in Relapsed Childhood ALL and AML.

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Targeting Histone Deacetylase 11 with a Highly Selective Inhibitor for the Treatment of MASLD.

• Authors : Zhang, Feng^1,2 (AUTHOR); Yue, Kairui³ (AUTHOR); Sun, Simin³ (AUTHOR)

• Source: Advanced Science. 4/17/2025, Vol. 12 Issue 15, p1-20. 20p.

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ML385, a selective inhibitor of Nrf2, demonstrates efficacy in the treatment of adult T-cell leukemia.

• Authors : Ishikawa, Chie^1,2 (AUTHOR); Mori, Naoki¹ (AUTHOR)

• Source: Leukemia & Lymphoma. Apr2025, Vol. 66 Issue 4, p721-732. 12p.

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Identification of a Selective Inhibitor of Human NFS1, a Cysteine Desulfurase Involved in Fe-S Cluster Assembly, via Structure-Based Virtual Screening.

• Authors : Zhu, Zhilong¹ (AUTHOR); Gan, Haisheng¹ (AUTHOR); Wang, Yanxiong¹ (AUTHOR)

Subjects: *VIRTUAL high-throughput screening (Drug development); *VITAMIN B6; *GLUTATHIONE reductase

• Source: International Journal of Molecular Sciences. Mar2025, Vol. 26 Issue 6, p2782. 20p.

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Selective Inhibitor Design against Thymidylate Synthase of Mycobacterium tuberculosis Using Alchemical Simulations

• Authors : Pallav Sengupta; Priyadarshi Satpati

Subjects: Chemistry; QD1-999

• Source: ACS Omega, Vol 10, Iss 14, Pp 13966-13976 (2025)

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Antitumor activity and low gastrointestinal toxicity of a novel selective inhibitor of nuclear export, SZJK-0421, in multiple myeloma

• Authors : Jing Wang; Hang Miao; Xuxing Shen

Subjects: Multiple myeloma; Selective inhibitor; Nuclear export

• Source: Acta Pharmaceutica Sinica B, Vol 14, Iss 7, Pp 3281-3285 (2024)

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