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  • 1-10 ل  180 نتائج ل ""Piperazines pharmacology""

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Academic Journal

Cyclin-dependent kinase 4 drives cystic kidney disease in the absence of mTORC1 signaling activity

Subjects: CDK4; mTOR pathway; SDG 3 - Good Health and Well-being

  • Source: Kidney international, vol. 106, no. 5, pp. 856-869Grahammer, F, Dumoulin, B, Gulieva, R E, Wu, H, Xu, Y, Sulaimanov, N, Arnold, F, Sandner, L, Cordts, T, Todkar, A, Moulin, P, Reichardt, W,

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Academic Journal

EWS-WT1 fusion isoforms establish oncogenic programs and therapeutic vulnerabilities in desmoplastic small round cell tumors

Subjects: 0301 basic medicine; Oncogene Proteins, Fusion; Pyridines

  • Source: Nat CommunNature Communications, Vol 15, Iss 1, Pp 1-17 (2024)Nature communications, vol. 15, no. 1, pp. 7460Nature Communications, vol 15, iss 1

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Academic Journal

Activation of the 5-HT1A Receptor by Eltoprazine Restores Mitochondrial and Motor Deficits in a Drosophila Model of Fragile X Syndrome

Subjects: FXS therapy; neuromuscular junction; Serotonin 5-HT1 Receptor Agonists

  • Source: Int J Mol SciInternational journal of molecular sciences, vol. 25, no. 16

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Academic Journal

Implications of Tamoxifen Resistance in Palbociclib Efficacy for Patients with Hormone Receptor-Positive, HER2-Negative Metastatic Breast Cancer: Subgroup Analyses of KCSG-BR15-10 (YoungPEARL)

Subjects: Breast Neoplasms / therapy; Androstadienes / pharmacology; Pyridines

  • Source: Cancer Res Treat

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Academic Journal

CRISPR-Mediated Kinome Editing Prioritizes a Synergistic Combination Therapy for FGFR1-Amplified Lung Cancer

Subjects: Male; Aged; Animals

  • Source: Cancer research, vol. 81, no. 11, pp. 3121-3133

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Academic Journal

Binding and activation of serotonergic G-protein coupled receptors by the multimodal antidepressant vortioxetine

Subjects: DYNAMICS; Serotonin; PREDICTION

  • Source: Ladefoged, L K, Koch, R, Biggin, P C & Schiøtt, B 2022, ' Binding and Activation of Serotonergic G-Protein Coupled Receptors by the Multimodal Antidepressant Vortioxetine ', ACS Chemical

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Academic Journal

CDK4/6 inhibition presents as a therapeutic option for paediatric and adult germ cell tumours and induces cell cycle arrest and apoptosis via canonical and non-canonical mechanisms

Subjects: Adult; Male; 0301 basic medicine

  • Source: Br J Cancer

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Academic Journal

Tumour kinome re-wiring governs resistance to palbociclib in oestrogen receptor positive breast cancers, highlighting new therapeutic modalities

Subjects: Fulvestrant/administration & dosage; Pyridines; Nude

  • Source: Oncogene

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Academic Journal

Imatinib mesylate radiosensitizes human glioblastoma cells through inhibition of platelet-derived growth factor receptor.

Subjects: Benzamides; Breast Neoplasms; Cell Line

  • Source: Blood cells, molecules & diseases. 34(2)

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Academic Journal

Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response

Subjects: Pyridines; Knockout; Science

  • Source: Nat CommunNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)Nature communications, vol. 12, no. 1, pp. 1998Nature Communications

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  • 1-10 ل  180 نتائج ل ""Piperazines pharmacology""