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Concomitant targeting of FLT3 and SPHK1 exerts synergistic cytotoxicity in FLT3-ITD + acute myeloid leukemia by inhibiting β-catenin activity via the PP2A-GSK3β axis.

• Authors : Jiang L; Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China.; Zhao Y

Subjects: fms-Like Tyrosine Kinase 3*/fms-Like Tyrosine Kinase 3*/fms-Like Tyrosine Kinase 3*/genetics ; fms-Like Tyrosine Kinase 3*/fms-Like Tyrosine Kinase 3*/fms-Like Tyrosine Kinase 3*/metabolism ; fms-Like Tyrosine Kinase 3*/fms-Like Tyrosine Kinase 3*/fms-Like Tyrosine Kinase 3*/antagonists & inhibitors

• Source: Cell communication and signaling : CCS [Cell Commun Signal] 2024 Aug 07; Vol. 22 (1), pp. 391. Date of Electronic Publication: 2024 Aug 07.Publisher: BioMed Central Country of Publication: England NLM ID: 101170464 Publication Model: Electronic Cited Medium: Internet ISSN: 1478-811X

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Deletion of Sphingosine Kinase 2 Attenuates Acute Kidney Injury in Mice with Hemolytic-Uremic Syndrome.

• Authors : Müller T; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, 07743 Jena, Germany.; ZIK Septomics Research Center, Jena University Hospital, 07743 Jena, Germany.

Subjects: Phosphotransferases (Alcohol Group Acceptor)*/Phosphotransferases (Alcohol Group Acceptor)*/Phosphotransferases (Alcohol Group Acceptor)*/genetics ; Phosphotransferases (Alcohol Group Acceptor)*/Phosphotransferases (Alcohol Group Acceptor)*/Phosphotransferases (Alcohol Group Acceptor)*/metabolism ; Acute Kidney Injury*/Acute Kidney Injury*/Acute Kidney Injury*/metabolism

• Source: International journal of molecular sciences [Int J Mol Sci] 2024 Jul 12; Vol. 25 (14). Date of Electronic Publication: 2024 Jul 12.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Exploring the Potential Role of Oligodendrocyte-Associated PIP4K2A in Alzheimer's Disease Complicated with Type 2 Diabetes Mellitus via Multi-Omic Analysis.

• Authors : Nguyen DPQ; Ph.D. Program in Medical Biotechnology, College of Medical Science and Technology, Taipei Medical University, New Taipei City 235, Taiwan.; Institute of Biomedicine, Hue University of Medicine and Pharmacy, Hue University, Hue City 49120, Vietnam.

Subjects: Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/metabolism ; Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/genetics ; Diabetes Mellitus, Type 2*/Diabetes Mellitus, Type 2*/Diabetes Mellitus, Type 2*/complications

• Source: International journal of molecular sciences [Int J Mol Sci] 2024 Jun 17; Vol. 25 (12). Date of Electronic Publication: 2024 Jun 17.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Multi-omics reveals new links between Fructosamine-3-Kinase (FN3K) and core metabolic pathways.

• Authors : Shrestha S; Institute of Bioinformatics, University of Georgia, Athens, GA, USA.; Taujale R

Subjects: Phosphotransferases (Alcohol Group Acceptor)*/Phosphotransferases (Alcohol Group Acceptor)*/Phosphotransferases (Alcohol Group Acceptor)*/metabolism ; Phosphotransferases (Alcohol Group Acceptor)*/Phosphotransferases (Alcohol Group Acceptor)*/Phosphotransferases (Alcohol Group Acceptor)*/genetics ; Metabolic Networks and Pathways*/Metabolic Networks and Pathways*/Metabolic Networks and Pathways*/genetics

• Source: NPJ systems biology and applications [NPJ Syst Biol Appl] 2024 Jun 03; Vol. 10 (1), pp. 64. Date of Electronic Publication: 2024 Jun 03.Publisher: Nature Publishing Group in partnership with SBI, The Systems Biology Institute Country of Publication: England NLM ID: 101677786 Publication Model:

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Signal Transduction of Transient Receptor Potential TRPM8 Channels: Role of PIP5K, Gq-Proteins, and c-Jun.

• Authors : Thiel G; Department of Medical Biochemistry and Molecular Biology, Medical Faculty, Saarland University, 66421 Homburg, Germany.; Rössler OG

Subjects: TRPM Cation Channels*/TRPM Cation Channels*/TRPM Cation Channels*/metabolism ; TRPM Cation Channels*/TRPM Cation Channels*/TRPM Cation Channels*/genetics ; GTP-Binding Protein alpha Subunits, Gq-G11*/GTP-Binding Protein alpha Subunits, Gq-G11*/GTP-Binding Protein alpha Subunits, Gq-G11*/metabolism

• Source: Molecules (Basel, Switzerland) [Molecules] 2024 Jun 01; Vol. 29 (11). Date of Electronic Publication: 2024 Jun 01.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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MATERIALS AND METHODS FOR IMPROVED PHOSPHOTRANSFERASES

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Network analysis and experimental verification of Salvia miltiorrhiza Bunge-Reynoutria japonica Houtt. drug pair in the treatment of non-alcoholic fatty liver disease.

• Authors : Chen, Huafeng^1,2 (AUTHOR); Yan, Shengzhe¹ (AUTHOR); Xiang, Qianru³ (AUTHOR)

Subjects: *PHYTOTHERAPY; *PROTEIN metabolism; *NON-alcoholic fatty liver disease

• Source: BMC Complementary Medicine & Therapies. 8/14/2024, Vol. 24 Issue 1, p1-17. 17p.

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Predisposing deleterious variants in the cancer-associated human kinases in the global populations.

• Authors : Khan, Salman Ahmed^1,2 (AUTHOR) ; Anwar, Misbah³ (AUTHOR); Gohar, Atia⁴ (AUTHOR)

Subjects: *LUNGS; *HUMAN genetic variation; *KINASES

• Source: PLoS ONE. 4/18/2024, Vol. 19 Issue 4, p1-16. 16p.

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Inhibition of Shikimate Kinase from Methicillin-Resistant Staphylococcus aureus by Benzimidazole Derivatives. Kinetic, Computational, Toxicological, and Biological Activity Studies.

• Authors : Rios-Soto L; Facultad de Medicina y Nutrición, Universidad Juárez del Estado de Durango, Av. Universidad y Fanny, Anitúa S/N, Durango 34000, Mexico.; Hernández-Campos A

Subjects: Methicillin-Resistant Staphylococcus aureus*/Methicillin-Resistant Staphylococcus aureus*/Methicillin-Resistant Staphylococcus aureus*/drug effects ; Methicillin-Resistant Staphylococcus aureus*/Methicillin-Resistant Staphylococcus aureus*/Methicillin-Resistant Staphylococcus aureus*/enzymology ; Phosphotransferases (Alcohol Group Acceptor)*/Phosphotransferases (Alcohol Group Acceptor)*/Phosphotransferases (Alcohol Group Acceptor)*/antagonists & inhibitors

• Source: International journal of molecular sciences [Int J Mol Sci] 2024 May 07; Vol. 25 (10). Date of Electronic Publication: 2024 May 07.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Research Progress of Plant-Derived Natural Products against Drug-Resistant Cancer.

• Authors : Liu, Wenli¹ ; Wang, Yuqin¹; Xia, Lijie¹

Subjects: *BIOTHERAPY; *DRUG resistance in cancer cells; *AUTOPHAGY

• Source: Nutrients. Mar2024, Vol. 16 Issue 6, p797. 41p.

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