نتائج البحث

Addressing the oxamniquine in vitro-in vivo paradox to facilitate a new generation of anti-schistosome treatments

• Authors : Katalin Toth; Sevan Alwan; Susan Khan

Subjects: Oxamniquine; Schistosome; Schistosomiasis

• Source: International Journal for Parasitology: Drugs and Drug Resistance, Vol 21, Iss , Pp 65-73 (2023)

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Oxamniquine derivatives overcome Praziquantel treatment limitations for Schistosomiasis.

• Authors : Alwan, Sevan N.¹ (AUTHOR) ; Taylor, Alexander B.² (AUTHOR); Rhodes, Jayce³ (AUTHOR)

• Source: PLoS Pathogens. 7/10/2023, Vol. 19 Issue 7, p1-20. 20p.

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An iterative process produces oxamniquine derivatives that kill the major species of schistosomes infecting humans.

• Authors : Guzman MA; Departments of Biochemistry and Structural Biology, the University of Texas Health Science Center, San Antonio, Texas, United States of America.; Pathology and Laboratory Medicine, the University of Texas Health Science Center, San Antonio, Texas, United States of America.

Subjects: Anthelmintics/Anthelmintics/Anthelmintics/*pharmacology ; Oxamniquine/Oxamniquine/Oxamniquine/*analogs & derivatives ; Oxamniquine/Oxamniquine/Oxamniquine/*pharmacology

• Source: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2020 Aug 18; Vol. 14 (8), pp. e0008517. Date of Electronic Publication: 2020 Aug 18 (Print Publication: 2020).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet

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Why does oxamniquine kill Schistosoma mansoni and not S. haematobium and S. japonicum?

• Authors : Anastasia R. Rugel; Meghan A. Guzman; Alexander B. Taylor

Subjects: Schistosoma spp.; Drug binding; Oxamniquine

• Source: International Journal for Parasitology: Drugs and Drug Resistance, Vol 13, Iss , Pp 8-15 (2020)

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Oxamniquine derivatives overcome Praziquantel treatment limitations for Schistosomiasis.

• Authors : Sevan N Alwan; Alexander B Taylor; Jayce Rhodes

Subjects: Immunologic diseases. Allergy; RC581-607; Biology (General)

• Source: PLoS Pathogens, Vol 19, Iss 7, p e1011018 (2023)

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Assessment of tegumental damage to Schistosoma mansoni and S. haematobium after in vitro exposure to ferrocenyl, ruthenocenyl and benzyl derivatives of oxamniquine using scanning electron microscopy.

• Authors : Buchter V; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health institute, Socinstrasse 57, 4051, Basel, CH, Switzerland.; University of Basel, P.O. Box, 4003, Basel, CH, Switzerland.

Subjects: Organometallic Compounds/Organometallic Compounds/Organometallic Compounds/*pharmacology ; Oxamniquine/Oxamniquine/Oxamniquine/*pharmacology ; Schistosoma haematobium/Schistosoma haematobium/Schistosoma haematobium/*anatomy & histology

• Source: Parasites & vectors [Parasit Vectors] 2018 Nov 06; Vol. 11 (1), pp. 580. Date of Electronic Publication: 2018 Nov 06.Publisher: BioMed Central Country of Publication: England NLM ID: 101462774 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-3305

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Assessment of tegumental damage to Schistosoma mansoni and S. haematobium after in vitro exposure to ferrocenyl, ruthenocenyl and benzyl derivatives of oxamniquine using scanning electron microscopy

• Authors : Valentin Buchter; Jeannine Hess; Gilles Gasser

Subjects: Schistosomiasis; Organometallic derivatives; Oxamniquine

• Source: Parasites & Vectors, Vol 11, Iss 1, Pp 1-12 (2018)

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Multidisciplinary Preclinical Investigations on Three Oxamniquine Analogues as New Drug Candidates for Schistosomiasis*.

• Authors : Buchter V; Swiss Tropical and Public Health Institute, Socinstrasse 57, P.O. box, 4002, Basel, Switzerland.; University of Basel, Petersplatz 1, P.O. Box, 4001, Basel, Switzerland.

Subjects: Pharmaceutical Preparations* ; Schistosomiasis*/Schistosomiasis*/Schistosomiasis*/drug therapy ; Schistosomiasis mansoni*/Schistosomiasis mansoni*/Schistosomiasis mansoni*/drug therapy

• Source: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2020 Nov 26; Vol. 26 (66), pp. 15232-15241. Date of Electronic Publication: 2020 Oct 22.Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 9513783 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3765

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Structural and functional characterization of the enantiomers of the antischistosomal drug oxamniquine

• Source: PLoS Neglected Tropical Diseases (Online); 9; 10

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Large CRISPR-Cas-induced deletions in the oxamniquine resistance locus of the human parasite Schistosoma mansoni [version 2; peer review: 4 approved]

• Authors : Geetha Sankaranarayanan; Avril Coghlan; Patrick Driguez

Subjects: Medicine; Science

• Source: Wellcome Open Research, Vol 5 (2021)

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