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Beyond HRD Status:Unraveling Genetic Variants Impacting PARP Inhibitor Sensitivity in Advanced Ovarian Cancer

• Authors : Kjeldsen, Maj K.; Jørgensen, Morten; Grønseth, Dina Sofie B.

Subjects: Adult; Aged; BRCA1 Protein/genetics

• Source: Kjeldsen , M K , Jørgensen , M , Grønseth , D S B , Schønemann-Lund , M , Nyvang , G B , Haslund , C A , Knudsen , A O , Motavaf , A K , Malander , S , Anttila , M , Lindahl , G , Mäenpää , J ,

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Developing a DNA Methylation Signature to Differentiate High-Grade Serous Ovarian Carcinomas from Benign Ovarian Tumors

• Authors : Oliveira, Douglas V. N. P.; Biskup, Edyta; O'Rourke, Colm J.

Subjects: Humans; Female; DNA Methylation

• Source: Oliveira , D V N P , Biskup , E , O'Rourke , C J , Hentze , J L , Andersen , J B , Høgdall , C & Høgdall , E V 2024 , ' Developing a DNA Methylation Signature to Differentiate High-Grade Serous

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Cohort profile:a nationwide study in Dutch CHEK2 c.1100delC families using the infrastructure of the HEreditary Breast and Ovarian cancer study Netherlands - Hebon-CHEK2

• Authors : Schreurs, Maartje A C; Adank, Muriel A; Hollestelle, Antoinette

Subjects: Breast tumours; Cancer genetics; Epidemiology

• Source: Schreurs , M A C , Adank , M A , Hollestelle , A , de Groot , R , Stommel-Jenner , D J , Van Asperen , C J , Ausems , M G E M , Berger , L P V , Blok , M J , van Engelen , K , Hogervorst , F B L ,

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Long-term outcomes of PARP inhibitors in ovarian cancer: survival, adverse events, and post-progression insights.

• Authors : Tuninetti, V.; Marín-Jiménez, J.A.; Valabrega, G.

Subjects: Humans; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology

• Source: ESMO open, vol. 9, no. 11, pp. 103984

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hsa_circ_0020093 suppresses ovarian cancer progression by modulating LRPPRC activity and miR-107/LATS2 signaling

• Authors : Sun, Yu; Chen, Xiyi; Shi, Yaqian

Subjects: Animals; Cell Line; Tumor

• Source: Sun , Y , Chen , X , Shi , Y , Teng , F , Dai , C , Ge , L , Xu , J & Jia , X 2024 , ' hsa_circ_0020093 suppresses ovarian cancer progression by modulating LRPPRC

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Randomized trial promoting cancer genetic risk assessment when genetic counseling cost removed: 1-year follow-up

• Authors : An, Jinghua; McDougall, Jean; Lin, Yong

Subjects: Genetic Counseling; Ovarian Neoplasms / genetics

• Source: JNCI Cancer Spectrum

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Cost-Effectiveness of Gene-Specific Prevention Strategies for Ovarian and Breast Cancer

• Authors : Wei, Xia; Sun, Li; Slade, Eric

Subjects: Adult; Breast Neoplasms/genetics; Cost-Benefit Analysis

• Source: Wei , X , Sun , L , Slade , E , Fierheller , C T , Oxley , S , Kalra , A , Sia , J , Sideris , M , McCluggage , W G , Bromham , N , Dworzynski , K , Rosenthal , A N , Brentnall , A , Duffy , S , Evans

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Olaparib plus Durvalumab, with or without Bevacizumab, as Treatment in PARP Inhibitor-Naïve Platinum-Sensitive Relapsed Ovarian Cancer: A Phase II Multi-Cohort Study.

• Authors : Drew, Y.; Kim, J.W.; Penson, R.T. ...

Subjects: Humans; Female; Bevacizumab/adverse effects

• Source: Clinical cancer research, vol. 30, no. 1, pp. 50-62

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Multi-omics analysis reveals distinct non-reversion mechanisms of PARPi resistance in BRCA1- versus BRCA2-deficient mammary tumors

• Authors : Jinhyuk Bhin; Mariana Paes Dias; Ewa Gogola

Subjects: Animals; BRCA1 Protein / genetics; BRCA2 Protein / genetics

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High ATP6V1B1 expression is associated with poor prognosis and platinum‑based chemotherapy resistance in epithelial ovarian cancer

• Authors : Gwan Hee Han; Hee Yun; Joon-Yong Chung

Subjects: Biomarkers; Tumor / metabolism; Carcinoma

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