نتائج البحث

Targeting NAD Metabolism: Rational Design, Synthesis and In Vitro Evaluation of NAMPT/PARP1 Dual-Target Inhibitors as Anti-Breast Cancer Agents.

• Authors : Li, Yingpeng^1,2 (AUTHOR); Kong, Xianxiu^1,2 (AUTHOR); Chu, Xinhong^1,2 (AUTHOR)

Subjects: *POLY ADP ribose; *NAD (Coenzyme); *NICOTINAMIDE

• Source: Molecules. Jun2024, Vol. 29 Issue 12, p2836. 26p.

تفاصيل العنوان

Toxin-mediated depletion of NAD and NADP drives persister formation in a human pathogen.

• Authors : Santi, Isabella¹ (AUTHOR); Dias Teixeira, Raphael¹ (AUTHOR); Manfredi, Pablo¹ (AUTHOR)

Subjects: *DRUG tolerance; *PSEUDOMONAS aeruginosa; *HUMAN genome

• Source: EMBO Journal. Nov2024, Vol. 43 Issue 21, p5211-5236. 26p.

تفاصيل العنوان

CYP3A5 promotes glioblastoma stemness and chemoresistance through fine-tuning NAD + /NADH ratio.

• Authors : Hu W; School of Medicine, Chinese PLA General Hospital, Nankai University, Beijing, China.; Department of Neurosurgery, Institute of Neurosurgery of Chinese PLA, Medical School of Chinese PLA, Chinese PLA General Hospital, Beijing, China.

Subjects: Glioblastoma*/Glioblastoma*/Glioblastoma*/pathology ; Glioblastoma*/Glioblastoma*/Glioblastoma*/metabolism ; Glioblastoma*/Glioblastoma*/Glioblastoma*/drug therapy

• Source: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2025 Jan 03; Vol. 44 (1), pp. 3. Date of Electronic Publication: 2025 Jan 03.Publisher: BioMed Central Country of Publication: England NLM ID: 8308647 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-9966

تفاصيل العنوان

Nrf2 induction potency of plant-derived compounds determined using an antioxidant response element luciferase reporter and conventional NAD(P)H-quinone acceptor oxidoreductase 1 activity assay.

• Authors : Tamaru E; Diet & Well-being Research Institute, KAGOME CO, LTD. 17 Nishitomiyama, Nasushiobara, 329- 2762, Tochigi, Japan.; Kokubu D

Subjects: NF-E2-Related Factor 2*/NF-E2-Related Factor 2*/NF-E2-Related Factor 2*/metabolism ; NAD(P)H Dehydrogenase (Quinone)*/NAD(P)H Dehydrogenase (Quinone)*/NAD(P)H Dehydrogenase (Quinone)*/metabolism ; NAD(P)H Dehydrogenase (Quinone)*/NAD(P)H Dehydrogenase (Quinone)*/NAD(P)H Dehydrogenase (Quinone)*/genetics

• Source: BMC research notes [BMC Res Notes] 2024 Dec 20; Vol. 17 (1), pp. 373. Date of Electronic Publication: 2024 Dec 20.Publisher: Biomed Central Country of Publication: England NLM ID: 101462768 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-0500

تفاصيل العنوان

Functional Roles of the Charged Residues of the C- and M-Gates in the Yeast Mitochondrial NAD + Transporter Ndt1p.

• Authors : Miniero DV; Department of Biosciences, Biotechnology and Environment, University of Bari Aldo Moro, Via E. Orabona 4, 70125 Bari, Italy.; Department of Medicine and Surgery, LUM University Giuseppe Degennaro, 70010 Casamassima, Italy.

Subjects: Saccharomyces cerevisiae Proteins*/Saccharomyces cerevisiae Proteins*/Saccharomyces cerevisiae Proteins*/metabolism ; Saccharomyces cerevisiae Proteins*/Saccharomyces cerevisiae Proteins*/Saccharomyces cerevisiae Proteins*/chemistry ; Saccharomyces cerevisiae Proteins*/Saccharomyces cerevisiae Proteins*/Saccharomyces cerevisiae Proteins*/genetics

• Source: International journal of molecular sciences [Int J Mol Sci] 2024 Dec 18; Vol. 25 (24). Date of Electronic Publication: 2024 Dec 18.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

تفاصيل العنوان

Synthesis, Biological, and Computational Evaluations of Conformationally Restricted NAD-Mimics as Discriminant Inhibitors of Human NMN-Adenylyltransferase Isozymes.

• Authors : Matteucci, Federica¹ (AUTHOR) ; Ferrati, Marta¹ (AUTHOR) ; Spinozzi, Eleonora¹ (AUTHOR)

• Source: Pharmaceuticals (14248247). Jun2024, Vol. 17 Issue 6, p739. 15p.

تفاصيل العنوان

Nicotinamide Mononucleotide (NMN) Ameliorates Free Fatty Acid-Induced Pancreatic β-Cell Dysfunction via the NAD + /AMPK/SIRT1/HIF-1α Pathway.

• Authors : Wang, Yan¹ (AUTHOR) ; Liu, Si¹ (AUTHOR); Ying, Linyao¹ (AUTHOR)

Subjects: *FREE fatty acids; *AMP-activated protein kinases; *NICOTINAMIDE

• Source: International Journal of Molecular Sciences. Oct2024, Vol. 25 Issue 19, p10534. 14p.

تفاصيل العنوان

Accounting for NAD Concentrations in Genome-Scale Metabolic Models Captures Important Metabolic Alterations in NAD-Depleted Systems.

• Authors : Sauter, Roland¹ (AUTHOR) ; Sharma, Suraj² (AUTHOR) ; Heiland, Ines^1,3 (AUTHOR)

• Source: Biomolecules (2218-273X). May2024, Vol. 14 Issue 5, p602. 11p.

تفاصيل العنوان

Novel Approach to Skin Anti-Aging: Boosting Pharmacological Effects of Exogenous Nicotinamide Adenine Dinucleotide (NAD + ) by Synergistic Inhibition of CD38 Expression.

• Authors : Kang S; LG Household and Health Care R&D Center, Seoul 07795, Republic of Korea.; Park J

Subjects: NAD*/NAD*/NAD*/metabolism ; NAD*/NAD*/NAD*/pharmacology ; ADP-ribosyl Cyclase 1*/ADP-ribosyl Cyclase 1*/ADP-ribosyl Cyclase 1*/metabolism

• Source: Cells [Cells] 2024 Oct 30; Vol. 13 (21). Date of Electronic Publication: 2024 Oct 30.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409

تفاصيل العنوان

Adaptation of a Commercial NAD + Quantification Kit to Assay the Base-Exchange Activity and Substrate Preferences of SARM1.

• Authors : Cirilli, Ilenia¹ (AUTHOR) ; Amici, Adolfo¹ (AUTHOR) ; Gilley, Jonathan² (AUTHOR)

Subjects: *ION exchange (Chemistry); *NAD (Coenzyme); *BINDING site assay

• Source: Molecules. Feb2024, Vol. 29 Issue 4, p847. 12p.

تفاصيل العنوان