نتائج البحث

The indispensable role of Mediator complex subunit 27 during neurodevelopment.

• Authors : Li X; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong (CUHK), Hong Kong SAR, China.; Yiliyaer N

• Source: Cell & bioscience [Cell Biosci] 2025 Jun 16; Vol. 15 (1), pp. 83. Date of Electronic Publication: 2025 Jun 16.Publisher: BioMed Central Country of Publication: England NLM ID: 101561195 Publication Model: Electronic Cited Medium: Print ISSN: 2045-3701

تفاصيل العنوان

Structure of a stripped-down and tuned-up far-red phycobilisome.

• Authors : Consoli G; Department of Life Sciences, Imperial College, London, UK.; Leong HF

Subjects: Phycobilisomes*/Phycobilisomes*/Phycobilisomes*/chemistry ; Phycobilisomes*/Phycobilisomes*/Phycobilisomes*/metabolism ; Phycobilisomes*/Phycobilisomes*/Phycobilisomes*/ultrastructure

• Source: Communications biology [Commun Biol] 2025 Jun 10; Vol. 8 (1), pp. 907. Date of Electronic Publication: 2025 Jun 10.Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN:

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Structural insights into tRNA recognition of the human FTSJ1-THADA complex.

• Authors : Ishiguro K; Laboratory for Protein Functional and Structural Biology, RIKEN Center for Biosystems Dynamics Research, Yokohama, Kanagawa, Japan.; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.

Subjects: RNA, Transfer*/RNA, Transfer*/RNA, Transfer*/metabolism ; RNA, Transfer*/RNA, Transfer*/RNA, Transfer*/chemistry ; RNA, Transfer*/RNA, Transfer*/RNA, Transfer*/genetics

• Source: Communications biology [Commun Biol] 2025 Jun 07; Vol. 8 (1), pp. 893. Date of Electronic Publication: 2025 Jun 07.Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN:

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Benchmarking inverse folding models for antibody CDR sequence design.

• Authors : Li Y; BioMap Research, Haidian District, Beijing, China.; Lang Y

Subjects: Complementarity Determining Regions*/Complementarity Determining Regions*/Complementarity Determining Regions*/chemistry ; Complementarity Determining Regions*/Complementarity Determining Regions*/Complementarity Determining Regions*/genetics ; Protein Folding*

• Source: PloS one [PLoS One] 2025 Jun 04; Vol. 20 (6), pp. e0324566. Date of Electronic Publication: 2025 Jun 04 (Print Publication: 2025).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Structural insights from vaccine candidates for EV-D68.

• Authors : Cheng J; Vaccine Research Center, NIAID, National Institutes of Health, Bethesda, MD, 20892, USA.; Krug PW

Subjects: Enterovirus D, Human*/Enterovirus D, Human*/Enterovirus D, Human*/immunology ; Enterovirus D, Human*/Enterovirus D, Human*/Enterovirus D, Human*/ultrastructure ; Enterovirus D, Human*/Enterovirus D, Human*/Enterovirus D, Human*/genetics

• Source: Communications biology [Commun Biol] 2025 Jun 04; Vol. 8 (1), pp. 860. Date of Electronic Publication: 2025 Jun 04.Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN:

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Conserved domains and structural motifs that differentiate closely related Rex1 and Rex3 DEDDh exoribonucleases are required for their function in yeast.

• Authors : Daniels PW; School of Biosciences, The University of Sheffield, Sheffield, United Kingdom.; Kelly S

Subjects: Saccharomyces cerevisiae*/Saccharomyces cerevisiae*/Saccharomyces cerevisiae*/enzymology ; Saccharomyces cerevisiae*/Saccharomyces cerevisiae*/Saccharomyces cerevisiae*/genetics ; Saccharomyces cerevisiae*/Saccharomyces cerevisiae*/Saccharomyces cerevisiae*/metabolism

• Source: PloS one [PLoS One] 2025 Jun 02; Vol. 20 (6), pp. e0321120. Date of Electronic Publication: 2025 Jun 02 (Print Publication: 2025).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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The barley MLA13-AVR A13 heterodimer reveals principles for immunoreceptor recognition of RNase-like powdery mildew effectors.

• Authors : Lawson AW; Department of Plant Microbe Interactions, Max Planck Institute for Plant Breeding Research, 50829, Cologne, Germany.; Flores-Ibarra A

Subjects: Hordeum*/Hordeum*/Hordeum*/microbiology ; Hordeum*/Hordeum*/Hordeum*/metabolism ; Hordeum*/Hordeum*/Hordeum*/genetics

• Source: The EMBO journal [EMBO J] 2025 Jun; Vol. 44 (11), pp. 3210-3230. Date of Electronic Publication: 2025 Feb 13.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Oligomerised RIPK1 is the main core component of the CD95 necrosome.

• Authors : Ivanisenko NV; Translational Inflammation Research, Medical Faculty, Otto von Guericke University, Magdeburg, Germany.; König C

Subjects: Receptor-Interacting Protein Serine-Threonine Kinases*/Receptor-Interacting Protein Serine-Threonine Kinases*/Receptor-Interacting Protein Serine-Threonine Kinases*/metabolism ; Receptor-Interacting Protein Serine-Threonine Kinases*/Receptor-Interacting Protein Serine-Threonine Kinases*/Receptor-Interacting Protein Serine-Threonine Kinases*/chemistry ; Receptor-Interacting Protein Serine-Threonine Kinases*/Receptor-Interacting Protein Serine-Threonine Kinases*/Receptor-Interacting Protein Serine-Threonine Kinases*/genetics

• Source: The EMBO journal [EMBO J] 2025 Jun; Vol. 44 (11), pp. 3231-3265. Date of Electronic Publication: 2025 Apr 16.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Computational Modeling and Experimental Approaches for Understanding the Mechanisms of [FeFe]-Hydrogenase.

• Authors : Kim CA; School of Science and Engineering, Shenzhen Key Laboratory of Innovative Drug Synthesis, The Chinese University of Hong Kong, Shenzhen, Guangdong, 518172, P. R. China.; Wu J

Subjects: Hydrogenase*/Hydrogenase*/Hydrogenase*/chemistry ; Hydrogenase*/Hydrogenase*/Hydrogenase*/metabolism ; Iron-Sulfur Proteins*/Iron-Sulfur Proteins*/Iron-Sulfur Proteins*/chemistry

• Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Jun; Vol. 12 (21), pp. e2408297. Date of Electronic Publication: 2025 May 08.Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844

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Cross-cohort multi-omics analysis identifies novel clusters driven by EMT signatures in colorectal cancer

• Authors : Wu Ning; Wenqing Jia; Jingyuan Ning

Subjects: colorectal cancer; EMT; HOXC6

• Source: Frontiers in Immunology, Vol 16 (2025)

تفاصيل العنوان

Protocatechualdehyde attenuates oxidative stress in diabetic cataract via GLO1-mediated inhibition of AGE/RAGE glycosylation

• Authors : Xiao Cheng; Sixuan Zhao; Yucai Chen

Subjects: Protocatechualdehyde; Glo1; AGEs/RAGE

• Source: Frontiers in Pharmacology, Vol 16 (2025)

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Microheterogeneity in Liquid Water Associated with Hydrogen-Bond Cooperativity-IR Spectroscopic and MD Simulation Study of Temperature Effect.

• Authors : Filipczak, Paulina¹ (AUTHOR); Kozanecki, Marcin^1,2 (AUTHOR); Szala-Rearick, Joanna^1,2 (AUTHOR)

Subjects: *DISTRIBUTION (Probability theory); *TEMPERATURE effect; *POWER spectra

• Source: International Journal of Molecular Sciences. Jun2025, Vol. 26 Issue 11, p5187. 20p.

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A Personal Scientific Journey in Ophthalmology: Twenty-Five Years of Translating Research into Novel Therapies

• Authors : Dario Rusciano

Subjects: ophthalmic pathologies; neuroprotection; glaucoma

• Source: Pharmaceuticals, Vol 18, Iss 6, p 883 (2025)

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Structural insights into sigma class glutathione transferase from Taenia solium: Analysis and functional implications.

• Authors : Miranda-Blancas R; Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México, México.; García-Gutiérrez P

Subjects: Taenia solium*/Taenia solium*/Taenia solium*/enzymology ; Taenia solium*/Taenia solium*/Taenia solium*/genetics ; Taenia solium*/Taenia solium*/Taenia solium*/chemistry

• Source: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2025 May 30; Vol. 19 (5), pp. e0013024. Date of Electronic Publication: 2025 May 30 (Print Publication: 2025).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet

تفاصيل العنوان

Cryo-EM structures of HCV E2 glycoprotein bound to neutralizing and non-neutralizing antibodies determined using bivalent Fabs as fiducial markers.

• Authors : Shahid S; W.M. Keck Laboratory for Structural Biology, University of Maryland-Institute for Bioscience and Biotechnology Research, Rockville, MD, USA.; Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, USA.

Subjects: Cryoelectron Microscopy*/Cryoelectron Microscopy*/Cryoelectron Microscopy*/methods ; Viral Envelope Proteins*/Viral Envelope Proteins*/Viral Envelope Proteins*/immunology ; Viral Envelope Proteins*/Viral Envelope Proteins*/Viral Envelope Proteins*/chemistry

• Source: Communications biology [Commun Biol] 2025 May 29; Vol. 8 (1), pp. 825. Date of Electronic Publication: 2025 May 29.Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN:

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The Construction of a Molecular Model for the Ternary Protein Complex of Intrinsic Coagulation Pathway Factors Provides Novel Insights for the Pathogenesis of Cross-Reactive Material Positive Coagulation Factor Mutations.

• Authors : Jiang S; State Key Laboratory of Microbial Metabolism & Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.; Li F

Subjects: Mutation* ; Factor VIIIa*/Factor VIIIa*/Factor VIIIa*/chemistry ; Factor VIIIa*/Factor VIIIa*/Factor VIIIa*/genetics

• Source: International journal of molecular sciences [Int J Mol Sci] 2025 May 28; Vol. 26 (11). Date of Electronic Publication: 2025 May 28.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

تفاصيل العنوان

Conserved structural topologies in RNase A-like and trypsin-like serine proteases: a sequence-based folding analysis.

• Authors : Kabir KMA; Research Organization of Science and Technology, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu-City, Shiga, Japan.; Takahashi T

Subjects: Protein Folding* ; Ribonuclease, Pancreatic*/Ribonuclease, Pancreatic*/Ribonuclease, Pancreatic*/chemistry ; Ribonuclease, Pancreatic*/Ribonuclease, Pancreatic*/Ribonuclease, Pancreatic*/metabolism

• Source: BMC molecular and cell biology [BMC Mol Cell Biol] 2025 May 28; Vol. 26 (1), pp. 16. Date of Electronic Publication: 2025 May 28.Publisher: BioMed Central Country of Publication: England NLM ID: 101741148 Publication Model: Electronic Cited Medium: Internet ISSN: 2661-8850

تفاصيل العنوان

Structure-Property Relationships in Zwitterionic Pyridinium-Triazole Ligands: Insights from Crystal Engineering and Hirshfeld Surface Analysis.

• Authors : Delgado GE; Departamento de Química, Facultad de Ciencias, Universidad de los Andes, Mérida 5101, Venezuela.; Cisterna J

Subjects: Triazoles*/Triazoles*/Triazoles*/chemistry ; Pyridinium Compounds*/Pyridinium Compounds*/Pyridinium Compounds*/chemistry; Ligands

• Source: International journal of molecular sciences [Int J Mol Sci] 2025 May 27; Vol. 26 (11). Date of Electronic Publication: 2025 May 27.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

تفاصيل العنوان

Streamlined Postprocessing of NMR Structures with the Molecular Restrainer: A Universal Tool for High-Quality Protein-Ligand Models and Non-Standard Amino Acid Residues.

• Authors : Mareš J; Department of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, 1090 Vienna, Austria.; Tarang GS

Subjects: Proteins*/Proteins*/Proteins*/chemistry ; Software* ; Amino Acids*/Amino Acids*/Amino Acids*/chemistry

• Source: International journal of molecular sciences [Int J Mol Sci] 2025 May 26; Vol. 26 (11). Date of Electronic Publication: 2025 May 26.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

تفاصيل العنوان

The crystal structure of GH57 family amylopullulanase reveals its dual binding pockets sharing the same catalytic dyad.

• Authors : Zhu Z; Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.

Subjects: Glycoside Hydrolases*/Glycoside Hydrolases*/Glycoside Hydrolases*/chemistry ; Glycoside Hydrolases*/Glycoside Hydrolases*/Glycoside Hydrolases*/metabolism ; Glycoside Hydrolases*/Glycoside Hydrolases*/Glycoside Hydrolases*/genetics

• Source: Communications biology [Commun Biol] 2025 May 26; Vol. 8 (1), pp. 806. Date of Electronic Publication: 2025 May 26.Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN:

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Building molecular model series from heterogeneous CryoEM structures using Gaussian mixture models and deep neural networks.

• Authors : Chen M; Division of CryoEM and Bioimaging, SSRL, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA, USA. .

Subjects: Cryoelectron Microscopy*/Cryoelectron Microscopy*/Cryoelectron Microscopy*/methods ; Models, Molecular* ; Neural Networks, Computer*

• Source: Communications biology [Commun Biol] 2025 May 25; Vol. 8 (1), pp. 798. Date of Electronic Publication: 2025 May 25.Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN:

تفاصيل العنوان

The Electronic Properties of Cordycepin in the Adenine Nucleoside Landscape: A Theoretical Approach.

• Authors : Karwowski BT; Nucleic Acids Damage Laboratory, Faculty of Pharmacy, Medical University of Lodz, ul. Muszynskiego 1, 90-151 Lodz, Poland.

Subjects: Deoxyadenosines*/Deoxyadenosines*/Deoxyadenosines*/chemistry ; Electrons* ; Adenine*/Adenine*/Adenine*/chemistry

• Source: Molecules (Basel, Switzerland) [Molecules] 2025 May 23; Vol. 30 (11). Date of Electronic Publication: 2025 May 23.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

تفاصيل العنوان

Molecular mechanism underlying non-discriminatory recognition of relaxin-3 by RXFP3 and RXFP4.

• Authors : Chen Y; Research Center for Medicinal Structural Biology, National Research Center for Translational Medicine at Shanghai, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Zhou Q

Subjects: Receptors, G-Protein-Coupled*/Receptors, G-Protein-Coupled*/Receptors, G-Protein-Coupled*/metabolism ; Receptors, G-Protein-Coupled*/Receptors, G-Protein-Coupled*/Receptors, G-Protein-Coupled*/chemistry ; Receptors, G-Protein-Coupled*/Receptors, G-Protein-Coupled*/Receptors, G-Protein-Coupled*/genetics

• Source: Communications biology [Commun Biol] 2025 May 23; Vol. 8 (1), pp. 794. Date of Electronic Publication: 2025 May 23.Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN:

تفاصيل العنوان

Valence Bond Insights into the H-Abstraction Barrier in Cytochrome P450.

• Authors : Zhang E; Warshel Institute for Computational Biology, School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, China.; Hirao H

Subjects: Cytochrome P-450 Enzyme System*/Cytochrome P-450 Enzyme System*/Cytochrome P-450 Enzyme System*/chemistry ; Cytochrome P-450 Enzyme System*/Cytochrome P-450 Enzyme System*/Cytochrome P-450 Enzyme System*/metabolism ; Hydrogen*/Hydrogen*/Hydrogen*/chemistry

• Source: Molecules (Basel, Switzerland) [Molecules] 2025 May 21; Vol. 30 (10). Date of Electronic Publication: 2025 May 21.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

تفاصيل العنوان

Structure of MICU from non-metazoan Dictyostelium discoideum reveals unique characteristics.

• Authors : Jin M; School of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea.; Steitz Center for Structural Biology, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea.

Subjects: Dictyostelium*/Dictyostelium*/Dictyostelium*/metabolism ; Dictyostelium*/Dictyostelium*/Dictyostelium*/genetics ; Dictyostelium*/Dictyostelium*/Dictyostelium*/chemistry

• Source: Communications biology [Commun Biol] 2025 May 21; Vol. 8 (1), pp. 782. Date of Electronic Publication: 2025 May 21.Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN:

تفاصيل العنوان

Cation and Spin Interactions in Cadmium Ferrite: A Quantum Mechanical Study.

• Authors : Almutairi TS; Section of Physical Chemistry, Department of Chemistry, Taibah University, Madinah 42353, Saudi Arabia.

Subjects: Ferric Compounds*/Ferric Compounds*/Ferric Compounds*/chemistry ; Cadmium*/Cadmium*/Cadmium*/chemistry ; Cations*/Cations*/Cations*/chemistry

• Source: International journal of molecular sciences [Int J Mol Sci] 2025 May 20; Vol. 26 (10). Date of Electronic Publication: 2025 May 20.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

تفاصيل العنوان

Pharmacophore Modeling of Janus Kinase Inhibitors: Tools for Drug Discovery and Exposition Prediction.

• Authors : Fischer F; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy and Research and Innovation Center for Regenerative Medicine and Novel Therapies, Paracelsus Medical University, 5020 Salzburg, Austria.; Temml V

Subjects: Drug Discovery* ; Janus Kinase Inhibitors*/Janus Kinase Inhibitors*/Janus Kinase Inhibitors*/chemistry ; Janus Kinase Inhibitors*/Janus Kinase Inhibitors*/Janus Kinase Inhibitors*/pharmacology

• Source: Molecules (Basel, Switzerland) [Molecules] 2025 May 16; Vol. 30 (10). Date of Electronic Publication: 2025 May 16.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

تفاصيل العنوان

EnGCI: enhancing GPCR-compound interaction prediction via large molecular models and KAN network.

• Authors : Liu W; Computer School, Hubei University of Arts and Science, Longzhong Road, Xiangyang, 441053, Hubei, China.; Li X

Subjects: Receptors, G-Protein-Coupled*/Receptors, G-Protein-Coupled*/Receptors, G-Protein-Coupled*/chemistry ; Receptors, G-Protein-Coupled*/Receptors, G-Protein-Coupled*/Receptors, G-Protein-Coupled*/metabolism ; Drug Discovery*/Drug Discovery*/Drug Discovery*/methods

• Source: BMC biology [BMC Biol] 2025 May 15; Vol. 23 (1), pp. 136. Date of Electronic Publication: 2025 May 15.Publisher: BioMed Central Country of Publication: England NLM ID: 101190720 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-7007

تفاصيل العنوان

Crystal Structure of the Multidomain Pectin Methylesterase PmeC5 from Butyrivibrio fibrisolvens D1 T .

• Authors : Carbone V; AgResearch Limited, Grasslands Research Centre, Palmerston North 4442, New Zealand.; Reilly K

Subjects: Carboxylic Ester Hydrolases*/Carboxylic Ester Hydrolases*/Carboxylic Ester Hydrolases*/chemistry ; Carboxylic Ester Hydrolases*/Carboxylic Ester Hydrolases*/Carboxylic Ester Hydrolases*/metabolism ; Carboxylic Ester Hydrolases*/Carboxylic Ester Hydrolases*/Carboxylic Ester Hydrolases*/genetics

• Source: Biomolecules [Biomolecules] 2025 May 14; Vol. 15 (5). Date of Electronic Publication: 2025 May 14.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X

تفاصيل العنوان

CHCHD4 Oxidoreductase Activity: A Comprehensive Analysis of the Molecular, Functional, and Structural Properties of Its Redox-Regulated Substrates.

• Authors : Balasco N; Institute of Molecular Biology and Pathology, National Research Council (CNR), Department of Chemistry, University of Rome Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy.; Modjtahedi N

Subjects: Mitochondrial Proteins*/Mitochondrial Proteins*/Mitochondrial Proteins*/chemistry ; Mitochondrial Proteins*/Mitochondrial Proteins*/Mitochondrial Proteins*/metabolism ; Oxidoreductases*/Oxidoreductases*/Oxidoreductases*/metabolism

• Source: Molecules (Basel, Switzerland) [Molecules] 2025 May 10; Vol. 30 (10). Date of Electronic Publication: 2025 May 10.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

تفاصيل العنوان

Molecular basis of TRPV3 channel blockade by intracellular polyamines.

• Authors : Zhang J; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Subjects: TRPV Cation Channels*/TRPV Cation Channels*/TRPV Cation Channels*/metabolism ; TRPV Cation Channels*/TRPV Cation Channels*/TRPV Cation Channels*/antagonists & inhibitors ; TRPV Cation Channels*/TRPV Cation Channels*/TRPV Cation Channels*/chemistry

• Source: Communications biology [Commun Biol] 2025 May 10; Vol. 8 (1), pp. 727. Date of Electronic Publication: 2025 May 10.Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN:

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Metal-Involving Bifurcated Halogen Bonding with Iodide and Platinum(II) Center.

• Authors : Kryukova MA; Institute of Chemistry, Saint Petersburg State University, 7/9 Universitetskaya Nab., Saint Petersburg 199034, Russia.; Kostareva MB

Subjects: Iodides*/Iodides*/Iodides*/chemistry ; Platinum*/Platinum*/Platinum*/chemistry ; Halogens*/Halogens*/Halogens*/chemistry

• Source: International journal of molecular sciences [Int J Mol Sci] 2025 May 09; Vol. 26 (10). Date of Electronic Publication: 2025 May 09.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

تفاصيل العنوان

Scoring protein-ligand binding structures through learning atomic graphs with inter-molecular adjacency.

• Authors : Wang DD; School of Science and Technology, Hong Kong Metropolitan University, Ho Man Tin, Hong Kong.; Huang Y

Subjects: Proteins*/Proteins*/Proteins*/chemistry ; Proteins*/Proteins*/Proteins*/metabolism; Ligands

• Source: PLoS computational biology [PLoS Comput Biol] 2025 May 09; Vol. 21 (5), pp. e1013074. Date of Electronic Publication: 2025 May 09 (Print Publication: 2025).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238922 Publication Model: eCollection Cited Medium: Internet

تفاصيل العنوان

Two different and robustly modeled DNA binding modes of Competence Protein ComP - systematic modeling with AlphaFold 3, RoseTTAFold2NA, Chai-1 and re-docking in HADDOCK.

• Authors : Helsem SA; Department of Life Sciences and Health, Faculty of Health Sciences, OsloMet, Oslo, Norway.; Alfsnes K

Subjects: Bacterial Proteins*/Bacterial Proteins*/Bacterial Proteins*/metabolism ; Bacterial Proteins*/Bacterial Proteins*/Bacterial Proteins*/chemistry ; DNA-Binding Proteins*/DNA-Binding Proteins*/DNA-Binding Proteins*/chemistry

• Source: PloS one [PLoS One] 2025 May 08; Vol. 20 (5), pp. e0315160. Date of Electronic Publication: 2025 May 08 (Print Publication: 2025).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

تفاصيل العنوان

Synthesis of Diversely Substituted Diethyl (Pyrrolidin-2-Yl)Phosphonates.

• Authors : Bagán A; Laboratory of Medicinal Chemistry, Department of Pharmacology, Toxicology and Medicinal Chemistry, Faculty of Pharmacy and Fo Sciences, University of Barcelona, Av. Joan XXIII, 27-31, 08028 Barcelona, Spain.; Institute of Biomedicine, University of Barcelona, 08028 Barcelona, Spain.

Subjects: Organophosphonates*/Organophosphonates*/Organophosphonates*/chemical synthesis ; Organophosphonates*/Organophosphonates*/Organophosphonates*/chemistry ; Organophosphonates*/Organophosphonates*/Organophosphonates*/pharmacology

• Source: Molecules (Basel, Switzerland) [Molecules] 2025 May 07; Vol. 30 (9). Date of Electronic Publication: 2025 May 07.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

تفاصيل العنوان

Capsid Structure of the Fish Pathogen Syngnathus Scovelli Chapparvovirus Offers a New Perspective on Parvovirus Structural Biology.

• Authors : Penzes JJ; Institute for Quantitative Biomedicine, Rutgers, The State University of New Jersey, Piscataway, NJ 08812, USA.; Department of Entomology, Texas A&M University, College Station, TX 77845, USA.

Subjects: Capsid*/Capsid*/Capsid*/chemistry ; Capsid*/Capsid*/Capsid*/ultrastructure ; Capsid Proteins*/Capsid Proteins*/Capsid Proteins*/chemistry

• Source: Viruses [Viruses] 2025 May 06; Vol. 17 (5). Date of Electronic Publication: 2025 May 06.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915

تفاصيل العنوان

Structural Biology in the AlphaFold Era: How Far Is Artificial Intelligence from Deciphering the Protein Folding Code?

• Authors : Balasco N; Institute of Molecular Biology and Pathology, National Research Council (CNR), c/o Department Chemistry, Sapienza University of Rome, 00185 Rome, Italy.; Esposito L

Subjects: Protein Folding* ; Proteins*/Proteins*/Proteins*/chemistry ; Artificial Intelligence*

• Source: Biomolecules [Biomolecules] 2025 May 06; Vol. 15 (5). Date of Electronic Publication: 2025 May 06.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X

تفاصيل العنوان

M-DeepAssembly: enhanced DeepAssembly based on multi-objective multi-domain protein conformation sampling.

• Authors : Cui X; College of Information Engineering, Zhejiang University of Technology, Hangzhou, 310023, China.; Xia Y

Subjects: Proteins*/Proteins*/Proteins*/chemistry ; Computational Biology*/Computational Biology*/Computational Biology*/methods ; Deep Learning*

• Source: BMC bioinformatics [BMC Bioinformatics] 2025 May 05; Vol. 26 (1), pp. 120. Date of Electronic Publication: 2025 May 05.Publisher: BioMed Central Country of Publication: England NLM ID: 100965194 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2105

تفاصيل العنوان

Investigating the quaternary structure of a homomultimeric catechol 1,2-dioxygenase: An integrative structural biology study.

• Authors : Almeida-Juarez AG; Laboratorio de Bioquímica Estructural, Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, México.; Chodankar S

Subjects: Catechol 1,2-Dioxygenase*/Catechol 1,2-Dioxygenase*/Catechol 1,2-Dioxygenase*/chemistry ; Catechol 1,2-Dioxygenase*/Catechol 1,2-Dioxygenase*/Catechol 1,2-Dioxygenase*/metabolism ; Bacterial Proteins*/Bacterial Proteins*/Bacterial Proteins*/chemistry

• Source: PloS one [PLoS One] 2025 May 05; Vol. 20 (5), pp. e0315992. Date of Electronic Publication: 2025 May 05 (Print Publication: 2025).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

تفاصيل العنوان

Coevolution in human small Heat Shock Protein 1 is promoted by interactions between the Alpha-Crystallin domain and the disordered regions.

• Authors : Racigh V; Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, Bernal, Argentina.; Rodriguez Sawicki L

Subjects: Evolution, Molecular* ; alpha-Crystallins*/alpha-Crystallins*/alpha-Crystallins*/metabolism ; alpha-Crystallins*/alpha-Crystallins*/alpha-Crystallins*/chemistry

• Source: PloS one [PLoS One] 2025 May 05; Vol. 20 (5), pp. e0321163. Date of Electronic Publication: 2025 May 05 (Print Publication: 2025).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Structure of the complex of C1q-like 3 protein with adhesion-GPCR BAI3.

• Authors : Miao Y; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. .; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA. .

Subjects: Nerve Tissue Proteins*/Nerve Tissue Proteins*/Nerve Tissue Proteins*/metabolism ; Nerve Tissue Proteins*/Nerve Tissue Proteins*/Nerve Tissue Proteins*/chemistry ; Nerve Tissue Proteins*/Nerve Tissue Proteins*/Nerve Tissue Proteins*/genetics

• Source: Communications biology [Commun Biol] 2025 May 03; Vol. 8 (1), pp. 693. Date of Electronic Publication: 2025 May 03.Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN:

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A kinetic model for USP14 regulated substrate degradation in 26S proteasome.

• Authors : Wu D; The State Key Laboratory for Artificial Microstructures and Mesoscopic Physics, School of Physics, Peking University, Beijing, China.; Ouyang Q

Subjects: Proteasome Endopeptidase Complex*/Proteasome Endopeptidase Complex*/Proteasome Endopeptidase Complex*/metabolism ; Proteasome Endopeptidase Complex*/Proteasome Endopeptidase Complex*/Proteasome Endopeptidase Complex*/chemistry ; Ubiquitin Thiolesterase*/Ubiquitin Thiolesterase*/Ubiquitin Thiolesterase*/metabolism

• Source: PLoS computational biology [PLoS Comput Biol] 2025 May 02; Vol. 21 (5), pp. e1012761. Date of Electronic Publication: 2025 May 02 (Print Publication: 2025).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238922 Publication Model: eCollection Cited Medium: Internet

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Cryo-EM reveals mechanisms of natural RNA multivalency.

• Authors : Wang L; The State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital; The State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, National Center for Stomatology, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Subjects: Cryoelectron Microscopy* ; RNA*/RNA*/RNA*/chemistry ; RNA*/RNA*/RNA*/ultrastructure

• Source: Science (New York, N.Y.) [Science] 2025 May; Vol. 388 (6746), pp. 545-550. Date of Electronic Publication: 2025 Mar 13.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic

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Structural insights into small-molecule agonist recognition and activation of complement receptor C3aR.

• Authors : Kim J; Department of Biological Sciences, Seoul National University, Seoul, 08826, Republic of Korea.; Division of Biological Science and Technology, Yonsei University, Wonju, 26493, Republic of Korea.

Subjects: Receptors, Complement*/Receptors, Complement*/Receptors, Complement*/chemistry ; Receptors, Complement*/Receptors, Complement*/Receptors, Complement*/metabolism ; Receptors, Complement*/Receptors, Complement*/Receptors, Complement*/agonists

• Source: The EMBO journal [EMBO J] 2025 May; Vol. 44 (10), pp. 2803-2826. Date of Electronic Publication: 2025 Apr 07.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Dimerization of GAS2 mediates crosslinking of microtubules and F-actin.

• Authors : An J; Department of Cell Biology and Anatomy, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Imasaki T

Subjects: Microtubules*/Microtubules*/Microtubules*/metabolism ; Microtubules*/Microtubules*/Microtubules*/ultrastructure ; Microtubules*/Microtubules*/Microtubules*/chemistry

• Source: The EMBO journal [EMBO J] 2025 May; Vol. 44 (10), pp. 2997-3024. Date of Electronic Publication: 2025 Apr 01.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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LightRoseTTA: High-Efficient and Accurate Protein Structure Prediction Using a Light-Weight Deep Graph Model.

• Authors : Wang X; School of Computer Science and Engineering, Nanjing University of Science and Technology, Nanjing, 210094, China.; Zhang T

Subjects: Protein Conformation* ; Proteins*/Proteins*/Proteins*/chemistry ; Computational Biology*/Computational Biology*/Computational Biology*/methods

• Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 May; Vol. 12 (19), pp. e2309051. Date of Electronic Publication: 2025 Mar 25.Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844

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Alpha and Omega Classification of β-Lactamase/Transpeptidase-like Superfamily Proteins Based on the Comparison of Their Structural Catalytic Cores.

• Authors : Denesyuk AI; Structural Bioinformatics Laboratory, Biochemistry, InFLAMES Research Flagship Center, Faculty of Science and Engineering, Åbo Akademi University, 20520 Turku, Finland.; Denessiouk K

Subjects: beta-Lactamases*/beta-Lactamases*/beta-Lactamases*/chemistry ; beta-Lactamases*/beta-Lactamases*/beta-Lactamases*/classification ; Peptidyl Transferases*/Peptidyl Transferases*/Peptidyl Transferases*/chemistry

• Source: Molecules (Basel, Switzerland) [Molecules] 2025 Apr 30; Vol. 30 (9). Date of Electronic Publication: 2025 Apr 30.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Transmembrane Homodimers Interface Identification: Predicting Interface Residues in Alpha-Helical Transmembrane Protein Homodimers Using Sequential and Structural Features.

• Authors : Almalki B; Department of Computer and Information Sciences, University of Delaware, Smith Hall, 18 Amstel Avenue, Newark, DE 19716, USA.; Liao L

Subjects: Membrane Proteins*/Membrane Proteins*/Membrane Proteins*/chemistry ; Membrane Proteins*/Membrane Proteins*/Membrane Proteins*/metabolism ; Protein Multimerization*

• Source: International journal of molecular sciences [Int J Mol Sci] 2025 Apr 30; Vol. 26 (9). Date of Electronic Publication: 2025 Apr 30.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Synthesis and Characterisation of Multivariate Metal-Organic Frameworks for Controlled Doxorubicin Absorption and Release.

• Authors : Ahmed A; SSPC Research Ireland Centre for Pharmaceuticals, Ireland.; School of Biological and Chemical Sciences, College of Science and Engineering, University of Galway, H91 TK33 Galway, Ireland.

Subjects: Doxorubicin*/Doxorubicin*/Doxorubicin*/chemistry ; Doxorubicin*/Doxorubicin*/Doxorubicin*/pharmacokinetics ; Doxorubicin*/Doxorubicin*/Doxorubicin*/pharmacology

• Source: Molecules (Basel, Switzerland) [Molecules] 2025 Apr 29; Vol. 30 (9). Date of Electronic Publication: 2025 Apr 29.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Structure and Inhibition of the Human Na + /H + Exchanger SLC9B2.

• Authors : Jung S; Department of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm University, 171-65 Stockholm, Sweden.; Kokane S

Subjects: Sodium-Hydrogen Exchangers*/Sodium-Hydrogen Exchangers*/Sodium-Hydrogen Exchangers*/chemistry ; Sodium-Hydrogen Exchangers*/Sodium-Hydrogen Exchangers*/Sodium-Hydrogen Exchangers*/antagonists & inhibitors ; Sodium-Hydrogen Exchangers*/Sodium-Hydrogen Exchangers*/Sodium-Hydrogen Exchangers*/metabolism

• Source: International journal of molecular sciences [Int J Mol Sci] 2025 Apr 29; Vol. 26 (9). Date of Electronic Publication: 2025 Apr 29.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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