نتائج البحث

The oncogenic kinase TOPK upregulates in psoriatic keratinocytes and contributes to psoriasis progression by regulating neutrophils infiltration.

• Authors : Zeng F; Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. .; Du S

Subjects: Keratinocytes*/Keratinocytes*/Keratinocytes*/pathology ; Keratinocytes*/Keratinocytes*/Keratinocytes*/metabolism ; Neutrophil Infiltration*

• Source: Cell communication and signaling : CCS [Cell Commun Signal] 2024 Aug 01; Vol. 22 (1), pp. 386. Date of Electronic Publication: 2024 Aug 01.Publisher: BioMed Central Country of Publication: England NLM ID: 101170464 Publication Model: Electronic Cited Medium: Internet ISSN: 1478-811X

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RAF and MEK Inhibitors in Non-Small Cell Lung Cancer.

• Authors : Adamopoulos C; Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.; Department of Oncological Sciences, Precision Immunology Institute, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Subjects: Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/drug therapy ; Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/genetics ; Lung Neoplasms*/Lung Neoplasms*/Lung Neoplasms*/drug therapy

• Source: International journal of molecular sciences [Int J Mol Sci] 2024 Apr 24; Vol. 25 (9). Date of Electronic Publication: 2024 Apr 24.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Genome-wide identification of the mitogen-activated protein kinase kinases in pear and their functional analysis in response to black spot.

• Authors : Zan Zhang¹; Qiming Chen¹; Luting Jia¹

• Source: Horticulture Plant Journal. Aug2023, Vol. 9 Issue 4, p681-692. 12p.

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Phosphoproteome Reveals Extracellular Regulated Protein Kinase Phosphorylation Mediated by Mitogen-Activated Protein Kinase Kinase-Regulating Granulosa Cell Apoptosis in Broody Geese.

• Authors : Zhao S; Jiangsu Key Laboratory for Animal Genetic, Breeding and Molecular Design, Yangzhou University, Yangzhou 225009, China.; Gu T

Subjects: Mitogen-Activated Protein Kinase Kinases* ; Geese*/Geese*/Geese*/genetics; Female

• Source: International journal of molecular sciences [Int J Mol Sci] 2023 Jul 31; Vol. 24 (15). Date of Electronic Publication: 2023 Jul 31.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Genome-Wide Identification of the MAPK and MAPKK Gene Families in Response to Cold Stress in Prunus mume .

• Authors : Wen Z; Beijing Key Laboratory of Ornamental Plants Germplasm Innovation and Molecular Breeding, National Engineering Research Center for Floriculture, Beijing Laboratory of Urban and Rural Ecological Environment, School of Landscape Architecture, Beijing Forestry University, Beijing 100083, China.; Li M

Subjects: Mitogen-Activated Protein Kinase Kinases*/Mitogen-Activated Protein Kinase Kinases*/Mitogen-Activated Protein Kinase Kinases*/metabolism ; Prunus*/Prunus*/Prunus*/genetics ; Prunus*/Prunus*/Prunus*/metabolism

• Source: International journal of molecular sciences [Int J Mol Sci] 2023 May 16; Vol. 24 (10). Date of Electronic Publication: 2023 May 16.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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FYN/TOPK/HSPB1 axis facilitates the proliferation and metastasis of gastric cancer.

• Authors : Peng S; Department of Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou, University, Zhengzhou, 450052, China.; Yin Y

Subjects: Mitogen-Activated Protein Kinase Kinases*/Mitogen-Activated Protein Kinase Kinases*/Mitogen-Activated Protein Kinase Kinases*/genetics ; Stomach Neoplasms*/Stomach Neoplasms*/Stomach Neoplasms*/genetics; Humans

• Source: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2023 Apr 04; Vol. 42 (1), pp. 80. Date of Electronic Publication: 2023 Apr 04.Publisher: BioMed Central Country of Publication: England NLM ID: 8308647 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-9966

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Selective Eradication of Colon Cancer Cells Harboring PI3K and/or MAPK Pathway Mutations in 3D Culture by Combined PI3K/AKT/mTOR Pathway and MEK Inhibition.

• Authors : Atanasova VS; Institute of Medical Genetics, Medical University of Vienna, Währinger Straße 10, 1090 Vienna, Austria.; Riedl A

Subjects: Colonic Neoplasms*/Colonic Neoplasms*/Colonic Neoplasms*/drug therapy ; Colonic Neoplasms*/Colonic Neoplasms*/Colonic Neoplasms*/genetics ; Colonic Neoplasms*/Colonic Neoplasms*/Colonic Neoplasms*/metabolism

• Source: International journal of molecular sciences [Int J Mol Sci] 2023 Jan 14; Vol. 24 (2). Date of Electronic Publication: 2023 Jan 14.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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ROS is a master regulator of in vitro matriptase activation.

• Authors : Gaymon DO; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, United States of America.; Barndt R

Subjects: Phosphatidylinositol 3-Kinases* ; Mitogen-Activated Protein Kinase Kinases*; Reactive Oxygen Species/Reactive Oxygen Species/Reactive Oxygen Species/metabolism

• Source: PloS one [PLoS One] 2023 Jan 30; Vol. 18 (1), pp. e0267492. Date of Electronic Publication: 2023 Jan 30 (Print Publication: 2023).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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First-in-human phase I dose-escalation and dose-expansion trial of the selective MEK inhibitor HL-085 in patients with advanced melanoma harboring NRAS mutations.

• Authors : Wang X; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Renal Cancer and Melanoma, Peking University Cancer Hospital and Research Institute, Beijing, China.; Luo Z

Subjects: Melanoma*/Melanoma*/Melanoma*/drug therapy ; Melanoma*/Melanoma*/Melanoma*/genetics ; Mitogen-Activated Protein Kinase Kinases*/Mitogen-Activated Protein Kinase Kinases*/Mitogen-Activated Protein Kinase Kinases*/antagonists & inhibitors

• Source: BMC medicine [BMC Med] 2023 Jan 04; Vol. 21 (1), pp. 2. Date of Electronic Publication: 2023 Jan 04.Publisher: BioMed Central Country of Publication: England NLM ID: 101190723 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-7015

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In Vitro/In Vivo Translation of Synergistic Combination of MDM2 and MEK Inhibitors in Melanoma Using PBPK/PD Modelling: Part II.

• Authors : Witkowski J; Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland.; Adamed Pharma S.A., Adamkiewicza 6a, 05-152 Czosnów, Poland.

Subjects: Melanoma*/Melanoma*/Melanoma*/drug therapy ; Mitogen-Activated Protein Kinase Kinases*/Mitogen-Activated Protein Kinase Kinases*/Mitogen-Activated Protein Kinase Kinases*/antagonists & inhibitors ; Proto-Oncogene Proteins c-mdm2*/Proto-Oncogene Proteins c-mdm2*/Proto-Oncogene Proteins c-mdm2*/antagonists & inhibitors

• Source: International journal of molecular sciences [Int J Mol Sci] 2022 Oct 08; Vol. 23 (19). Date of Electronic Publication: 2022 Oct 08.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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