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  • 1-10 ل  313 نتائج ل ""MAP Kinase Kinase 2""

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Academic Journal

Architecture of the MKK6-p38α complex defines the basis of MAPK specificity and activation.

  • Authors : Juyoux P; European Molecular Biology Laboratory (EMBL), Grenoble, France.; Galdadas I

Subjects: MAP Kinase Kinase 2*/MAP Kinase Kinase 2*/MAP Kinase Kinase 2*/chemistry ; MAP Kinase Kinase 6*/MAP Kinase Kinase 6*/MAP Kinase Kinase 6*/chemistry ; Mitogen-Activated Protein Kinase 14*/Mitogen-Activated Protein Kinase 14*/Mitogen-Activated Protein Kinase 14*/chemistry

  • Source: Science (New York, N.Y.) [Science] 2023 Sep 15; Vol. 381 (6663), pp. 1217-1225. Date of Electronic Publication: 2023 Sep 14.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic

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Academic Journal

EGFR-MEK1/2 cascade negatively regulates bactericidal function of bone marrow macrophages in mice with Staphylococcus aureus osteomyelitis.

  • Authors : Jin M; Division of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, No.1838 North of Guangzhou Avenue, Guangzhou, Guangdong Province, China.; Guangdong Provincial Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Subjects: Osteomyelitis*/Osteomyelitis*/Osteomyelitis*/microbiology ; Osteomyelitis*/Osteomyelitis*/Osteomyelitis*/immunology ; Osteomyelitis*/Osteomyelitis*/Osteomyelitis*/metabolism

  • Source: PLoS pathogens [PLoS Pathog] 2024 Aug 05; Vol. 20 (8), pp. e1012437. Date of Electronic Publication: 2024 Aug 05 (Print Publication: 2024).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Dual Inhibition of DKC1 and MEK1/2 Synergistically Restrains the Growth of Colorectal Cancer Cells.

  • Authors : Kan G; State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat-sen University Cancer Center Guangzhou Guangdong 510060 P. R. China.; Wang Z

Subjects: Antineoplastic Combined Chemotherapy Protocols/Antineoplastic Combined Chemotherapy Protocols/Antineoplastic Combined Chemotherapy Protocols/*pharmacology ; Cell Cycle Proteins/Cell Cycle Proteins/Cell Cycle Proteins/*antagonists & inhibitors ; Colorectal Neoplasms/Colorectal Neoplasms/Colorectal Neoplasms/*drug therapy

  • Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2021 Mar 15; Vol. 8 (10), pp. 2004344. Date of Electronic Publication: 2021 Mar 15 (Print Publication: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: eCollection Cited Medium: Internet ISSN: 2198-3844

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Academic Journal

Acute mitogen-activated protein kinase 1/2 inhibition improves functional recovery and vascular changes after ischaemic stroke in rat-monitored by 9.4 T magnetic resonance imaging.

  • Authors : Mostajeran M; Division of Experimental Vascular Research, Department of Clinical Sciences, Lund University, Lund, Sweden.; Wetterling F

Subjects: Magnetic Resonance Imaging*; Brain/Brain/Brain/*drug effects ; Butadienes/Butadienes/Butadienes/*pharmacology

  • Source: Acta physiologica (Oxford, England) [Acta Physiol (Oxf)] 2018 May; Vol. 223 (1), pp. e12985. Date of Electronic Publication: 2017 Nov 12.Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101262545 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Phase II study of selumetinib, an orally active inhibitor of MEK1 and MEK2 kinases, in KRASG12R-mutant pancreatic ductal adenocarcinoma

Subjects: Biomedical and Clinical Sciences; Clinical Sciences; Oncology and Carcinogenesis

  • Source: Investigational New Drugs. 39(3)

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Academic Journal

Interaction of tRNA with MEK2 in pancreatic cancer cells.

  • Authors : Wang X; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA.; Chow CR

Subjects: MAP Kinase Kinase 2/MAP Kinase Kinase 2/MAP Kinase Kinase 2/*metabolism ; Pancreatic Neoplasms/Pancreatic Neoplasms/Pancreatic Neoplasms/*metabolism ; RNA, Transfer/RNA, Transfer/RNA, Transfer/*metabolism

  • Source: Scientific reports [Sci Rep] 2016 Jun 15; Vol. 6, pp. 28260. Date of Electronic Publication: 2016 Jun 15.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Huntingtin Subcellular Localisation Is Regulated by Kinase Signalling Activity in the StHdhQ111 Model of HD.

  • Authors : Bowles KR; Institute of Psychological Medicine and Clinical Neurosciences, MRC centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Hadyn Ellis building, Maindy Road, Cardiff University, Cardiff CF24 4HQ, Wales, United Kingdom.; Brooks SP

Subjects: Corpus Striatum/Corpus Striatum/Corpus Striatum/*metabolism ; Huntington Disease/Huntington Disease/Huntington Disease/*genetics ; MAP Kinase Kinase 1/MAP Kinase Kinase 1/MAP Kinase Kinase 1/*genetics

  • Source: PloS one [PLoS One] 2015 Dec 14; Vol. 10 (12), pp. e0144864. Date of Electronic Publication: 2015 Dec 14 (Print Publication: 2015).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Activation of MEK2 is sufficient to induce skin papilloma formation in transgenic zebrafish.

  • Authors : Chou CM; Department of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan. .; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan. .

Subjects: MAP Kinase Kinase 2/MAP Kinase Kinase 2/MAP Kinase Kinase 2/*metabolism ; Papilloma/Papilloma/Papilloma/*metabolism ; Skin Neoplasms/Skin Neoplasms/Skin Neoplasms/*metabolism

  • Source: Journal of biomedical science [J Biomed Sci] 2015 Nov 17; Vol. 22, pp. 102. Date of Electronic Publication: 2015 Nov 17.Publisher: BioMed Central Country of Publication: England NLM ID: 9421567 Publication Model: Electronic Cited Medium: Internet ISSN: 1423-0127

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Academic Journal

MEK1 and MEK2 inhibitors and cancer therapy: the long and winding road.

  • Authors : Caunt CJ; Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK.; Sale MJ

Subjects: MAP Kinase Kinase 1/MAP Kinase Kinase 1/MAP Kinase Kinase 1/*antagonists & inhibitors ; MAP Kinase Kinase 2/MAP Kinase Kinase 2/MAP Kinase Kinase 2/*antagonists & inhibitors ; Neoplasms/Neoplasms/Neoplasms/*drug therapy

  • Source: Nature reviews. Cancer [Nat Rev Cancer] 2015 Oct; Vol. 15 (10), pp. 577-92.Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101124168 Publication Model: Print Cited Medium: Internet ISSN: 1474-1768

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Academic Journal

Phase I dose-escalation trial of the oral AKT inhibitor uprosertib in combination with the oral MEK1/MEK2 inhibitor trametinib in patients with solid tumors

Subjects: Pharmacology and Pharmaceutical Sciences; Biomedical and Clinical Sciences; Clinical Sciences

  • Source: Cancer Chemotherapy and Pharmacology. 85(4)

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  • 1-10 ل  313 نتائج ل ""MAP Kinase Kinase 2""