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Computational insights into rational design and virtual screening of pyrazolopyrimidine derivatives targeting Janus kinase 3 (JAK3).

• Authors : Faris, Abdelmoujoud¹ ; Cacciatore, Ivana²; Alnajjar, Radwan³

• Source: Frontiers in Chemistry. 2024, p1-27. 27p.

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Docking and Selectivity Studies of Covalently Bound Janus Kinase 3 Inhibitors.

• Authors : Zhong HA; Department of Chemistry, The University of Nebraska at Omaha, 6001 Dodge Street, Omaha, NE 68182, USA.; Almahmoud S

Subjects: Janus Kinase 3* ; Protein Kinase Inhibitors*/Protein Kinase Inhibitors*/Protein Kinase Inhibitors*/pharmacology ; Protein Kinase Inhibitors*/Protein Kinase Inhibitors*/Protein Kinase Inhibitors*/chemistry

• Source: International journal of molecular sciences [Int J Mol Sci] 2023 Mar 23; Vol. 24 (7). Date of Electronic Publication: 2023 Mar 23.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Janus Kinase 3 (JAK3): A Critical Conserved Node in Immunity Disrupted in Immune Cell Cancer and Immunodeficiency.

• Authors : Liongue C; School of Medicine, Deakin University, Geelong, VIC 3216, Australia.; The Institute for Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, VIC 3216, Australia.

Subjects: Immunologic Deficiency Syndromes* ; Neoplasms*; Animals

• Source: International journal of molecular sciences [Int J Mol Sci] 2024 Mar 04; Vol. 25 (5). Date of Electronic Publication: 2024 Mar 04.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Epstein-Barr Virus BRRF1 Induces Butyrophilin 2A1 in Nasopharyngeal Carcinoma NPC43 Cells via the IL-22/JAK3-STAT3 Pathway.

• Authors : Liu Y; Medical School, Fuyang Normal University, Fuyang 236000, China.; Department of Biology, Faculty of Science, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China.

Subjects: STAT3 Transcription Factor*/STAT3 Transcription Factor*/STAT3 Transcription Factor*/metabolism ; Nasopharyngeal Carcinoma*/Nasopharyngeal Carcinoma*/Nasopharyngeal Carcinoma*/virology ; Nasopharyngeal Carcinoma*/Nasopharyngeal Carcinoma*/Nasopharyngeal Carcinoma*/metabolism

• Source: International journal of molecular sciences [Int J Mol Sci] 2024 Dec 15; Vol. 25 (24). Date of Electronic Publication: 2024 Dec 15.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Correlations of expressions of Toll-like receptor 4 and Janus kinase 3 in peripheral blood mononuclear cells with T helper 17 cell/regulatory T cell imbalance in patients with ankylosing spondylitis

• Authors : He Ruyan; Liu Guangpu; Gu Fang

Subjects: ankylosing spondylitis; correlation; expression

• Source: Romanian Journal of Laboratory Medicine, Vol 32, Iss 2, Pp 171-176 (2024)

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Janus Kinase 3 phosphorylation and the JAK/STAT pathway are positively modulated by follicle-stimulating hormone (FSH) in bovine granulosa cells.

• Authors : Zareifard A; Centre de Recherche en Reproduction Et Fertilité, Département de Biomédecine Vétérinaire, Faculté de Médecine Vétérinaire, CRRF, Université de Montréal, Saint-Hyacinthe, Québec, Canada.; Département de Biomédecine Vétérinaire, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, Québec, 3200, Canada.

Subjects: Follicle Stimulating Hormone*/Follicle Stimulating Hormone*/Follicle Stimulating Hormone*/pharmacology ; Janus Kinases*/Janus Kinases*/Janus Kinases*/metabolism; Animals

• Source: BMC molecular and cell biology [BMC Mol Cell Biol] 2023 Jun 20; Vol. 24 (1), pp. 21. Date of Electronic Publication: 2023 Jun 20.Publisher: BioMed Central Country of Publication: England NLM ID: 101741148 Publication Model: Electronic Cited Medium: Internet ISSN: 2661-8850

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Omenn syndrome in two infants with different hypomorphic variants in Janus kinase 3

• Authors : Tsilifis, Christo; Stremenova Spegarova, Jarmila; Good, Ross

Subjects: Severe combined immunodeficiency; Omenn syndrome; haematopoietic stem cell transplant

• Source: Tsilifis , C , Stremenova Spegarova , J , Good , R , Griffin , H , Engelhardt , K R , Graham , S , Hughes , S , Arkwright , P , Hambleton , S & Gennery , A R 2024 , ' Omenn syndrome in two infants

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Prevention of Organ Allograft Rejection by a Specific Janus Kinase 3 Inhibitor

• Authors : Changelian, Paul S.; Flanagan, Mark E.; Ball, Douglas J.

• Source: Science, 2003 Oct . 302(5646), 875-878.

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Molecular Modeling on the Identification of Potential Janus Kinase 3 (JAK3) Inhibitors Based on the Indonesian Medicinal Plant Database.

• Authors : Arba, Muhammad¹ ; Safitri, Sanang Nur¹; Hidayat, Andry-Nur¹

• Source: Journal of Mathematical & Fundamental Sciences. 2020, Vol. 52 Issue 3, p276-285. 10p.

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A Workflow Combining Machine Learning with Molecular Simulations Uncovers Potential Dual-Target Inhibitors against BTK and JAK3.

• Authors : Liu L; Institute of Theoretical Chemistry, Jilin University, Changchun 130061, China.; Na R

Subjects: Janus Kinase 3* ; Lymphoma, B-Cell*; Humans

• Source: Molecules (Basel, Switzerland) [Molecules] 2023 Oct 17; Vol. 28 (20). Date of Electronic Publication: 2023 Oct 17.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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