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Intervertebral Disc Degeneration: Prevalence, Risk Factors and Treatments

• Authors : Ho, Allen L.; Desai, Atman M.

Subjects: Intervertebral disk--DiseasesMEDICAL / Surgery / General

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Therapeutic potential of targeting the IRF2/POSTN/Notch1 axis in nucleus pulposus cells for intervertebral disc degeneration.

• Authors : Zhu D; Lanzhou University Second Hospital, 82 Cui-Ying-Men, Lanzhou, 730030, PR China.; Key Laboratory of Orthopedic Disease of Gansu Province, Lanzhou University Second Hospital, Lanzhou, 730030, PR China.

Subjects: Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/metabolism ; Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/pathology ; Nucleus Pulposus*/Nucleus Pulposus*/Nucleus Pulposus*/metabolism

• Source: Journal of neuroinflammation [J Neuroinflammation] 2025 Jan 22; Vol. 22 (1), pp. 13. Date of Electronic Publication: 2025 Jan 22.Publisher: BioMed Central Country of Publication: England NLM ID: 101222974 Publication Model: Electronic Cited Medium: Internet ISSN: 1742-2094

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Bioinformatics Analysis of Biomarkers and Therapeutic Targets Related to Necroptosis in Intervertebral Disc Degeneration.

• Authors : Zhang F; Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Kunming City, Yunnan 650032, China.; Yuan L

Subjects: Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/genetics ; Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/metabolism ; Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/pathology

• Source: BioMed research international [Biomed Res Int] 2024 Dec 16; Vol. 2024, pp. 9922966. Date of Electronic Publication: 2024 Dec 16 (Print Publication: 2024).Publisher: Wiley Country of Publication: United States NLM ID: 101600173 Publication Model: eCollection Cited Medium: Internet ISSN: 2314-6141

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Exploration and breakthrough in the mode of intervertebral disc cell death may lead to significant advances in treatments for intervertebral disc degeneration.

• Authors : Chen H; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210028, China.; Nanjing University of Chinese Medicine, Nanjing, 210028, China.

Subjects: Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/therapy ; Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/pathology ; Intervertebral Disc*/Intervertebral Disc*/Intervertebral Disc*/pathology

• Source: Journal of orthopaedic surgery and research [J Orthop Surg Res] 2024 Dec 05; Vol. 19 (1), pp. 825. Date of Electronic Publication: 2024 Dec 05.Publisher: BioMed Central Country of Publication: England NLM ID: 101265112 Publication Model: Electronic Cited Medium: Internet ISSN: 1749-799X

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Animal Models of Internal Endplate Injury-Induced Intervertebral Disc Degeneration: A Systematic Review.

• Authors : Ma Y; Department of Orthopaedic, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China.; Yu X

Subjects: Disease Models, Animal* ; Intervertebral Disc*/Intervertebral Disc*/Intervertebral Disc*/injuries ; Intervertebral Disc*/Intervertebral Disc*/Intervertebral Disc*/pathology

• Source: Journal of investigative surgery : the official journal of the Academy of Surgical Research [J Invest Surg] 2024 Dec; Vol. 37 (1), pp. 2400478. Date of Electronic Publication: 2024Publisher: Taylor & Francis Country of Publication: United States NLM ID: 8809255 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Effect of Different Injury Morphology of the Endplate on Intervertebral Disc Degeneration: Retrospective Cohort Study.

• Authors : Yu Q; Department of Traumatic Orthopedics, Suizhou Hospital, Hubei University of Medicine, Suizhou, Hubei, China.; Chen K

Subjects: Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/diagnostic imaging ; Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/pathology ; Lumbar Vertebrae*/Lumbar Vertebrae*/Lumbar Vertebrae*/injuries

• Source: Orthopaedic surgery [Orthop Surg] 2024 Dec; Vol. 16 (12), pp. 2995-3005. Date of Electronic Publication: 2024 Oct 02.Publisher: Wiley on behalf of the Chinese Orthopedic Association Country of Publication: Australia NLM ID: 101501666 Publication Model: Print-Electronic

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MARCHF8-mediated ubiquitination via TGFBI regulates NF-κB dependent inflammatory responses and ECM degradation in intervertebral disc degeneration.

• Authors : Zhang X; Department of Orthopedics, Shanghai Pudong New Area People's Hospital, Shanghai, China.; Li G

Subjects: Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/metabolism ; Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/genetics ; Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/pathology

• Source: PloS one [PLoS One] 2025 Jan 03; Vol. 20 (1), pp. e0314021. Date of Electronic Publication: 2025 Jan 03 (Print Publication: 2025).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Imaging observation of intervertebral disc degeneration in patients with old thoracolumbar fracture-related kyphotic deformity.

• Authors : Cui XL; Affiliated Fuyang People's Hospital of Anhui Medical University, Sanqing Road 501, Fuyang, 236000, Anhui, China.; School of Mechanical Engineering and Automation, Shanghai University, Shanghai, China.

Subjects: Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/diagnostic imaging ; Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/complications ; Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/pathology

• Source: Scientific reports [Sci Rep] 2024 Dec 28; Vol. 14 (1), pp. 31335. Date of Electronic Publication: 2024 Dec 28.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Intervertebral Disc Degeneration and Regeneration: New Molecular Mechanisms and Therapeutics: Obstacles and Potential Breakthrough Technologies.

• Authors : Taylor W; Department of Surgery, Division of Neurosurgery, University of California at San Diego, 9350 Campus Point Dr., La Jolla, CA 92037, USA.; Erwin WM

Subjects: Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/therapy ; Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/metabolism ; Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/pathology

• Source: Cells [Cells] 2024 Dec 19; Vol. 13 (24). Date of Electronic Publication: 2024 Dec 19.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409

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Nuclear receptor Rev-erbα alleviates intervertebral disc degeneration by recruiting NCoR-HDAC3 co-repressor and inhibiting NLRP3 inflammasome.

• Authors : Zhou Q; Division of Spine Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital Clinical College of Jiangsu University, Nanjing, China.; Division of Spine Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.

Subjects: NLR Family, Pyrin Domain-Containing 3 Protein*/NLR Family, Pyrin Domain-Containing 3 Protein*/NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism ; Nuclear Receptor Subfamily 1, Group D, Member 1*/Nuclear Receptor Subfamily 1, Group D, Member 1*/Nuclear Receptor Subfamily 1, Group D, Member 1*/metabolism ; Nuclear Receptor Subfamily 1, Group D, Member 1*/Nuclear Receptor Subfamily 1, Group D, Member 1*/Nuclear Receptor Subfamily 1, Group D, Member 1*/genetics

• Source: Cell proliferation [Cell Prolif] 2024 Dec; Vol. 57 (12), pp. e13720. Date of Electronic Publication: 2024 Jul 24.Publisher: Published for the Cell Kinetics Society, the European Study Group for Cell Proliferation, and the International Cell Cycle Society by Blackwell Scientific Publications

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