نتائج البحث

The FKBPL-based therapeutic peptide, AD-01, protects the endothelium from hypoxia-induced damage by stabilising hypoxia inducible factor-α and inflammation.

• Authors : Ghorbanpour S; School of Life Sciences & Institute for Biomedical Materials and Devices, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia.; Heart Research Institute, The University of Sydney, Sydney, NSW, Australia.

Subjects: Hypoxia-Inducible Factor 1, alpha Subunit*/Hypoxia-Inducible Factor 1, alpha Subunit*/Hypoxia-Inducible Factor 1, alpha Subunit*/metabolism ; Inflammation*/Inflammation*/Inflammation*/pathology ; Peptides*/Peptides*/Peptides*/pharmacology

• Source: Journal of translational medicine [J Transl Med] 2025 Mar 11; Vol. 23 (1), pp. 309. Date of Electronic Publication: 2025 Mar 11.Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876

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Hypoxia and HIF-1 inhibition enhance lentiviral transduction efficiency: a novel strategy for gene delivery optimization.

• Authors : Huo, Qianyu^1,2,3 (AUTHOR); Wang, Wentian^1,3 (AUTHOR); Dai, Jiawen^1,3 (AUTHOR)

Subjects: *HYPOXIA-inducible factor 1; *VIRAL genomes; *GENETIC transduction

• Source: BMC Biotechnology. 5/10/2025, Vol. 25 Issue 1, p1-8. 8p.

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CD133+CD24+ Renal Tubular Progenitor Cells Drive Hypoxic Injury Recovery via Hypoxia-Inducible Factor-1A and Epidermal Growth Factor Receptor Expression.

• Authors : Al-Marsoummi S; Department of Pathology, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA.; Singhal S

Subjects: AC133 Antigen*/AC133 Antigen*/AC133 Antigen*/metabolism ; Hypoxia-Inducible Factor 1, alpha Subunit*/Hypoxia-Inducible Factor 1, alpha Subunit*/Hypoxia-Inducible Factor 1, alpha Subunit*/metabolism ; Hypoxia-Inducible Factor 1, alpha Subunit*/Hypoxia-Inducible Factor 1, alpha Subunit*/Hypoxia-Inducible Factor 1, alpha Subunit*/genetics

• Source: International journal of molecular sciences [Int J Mol Sci] 2025 Mar 10; Vol. 26 (6). Date of Electronic Publication: 2025 Mar 10.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Intermittent hypoxic stimulation promotes efficient expression of Hypoxia-inducible factor-1α and exerts a chondroprotective effect in an animal osteoarthritis model.

• Authors : Cha R; Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.; Nakagawa S

Subjects: Hypoxia-Inducible Factor 1, alpha Subunit*/Hypoxia-Inducible Factor 1, alpha Subunit*/Hypoxia-Inducible Factor 1, alpha Subunit*/metabolism ; Hypoxia-Inducible Factor 1, alpha Subunit*/Hypoxia-Inducible Factor 1, alpha Subunit*/Hypoxia-Inducible Factor 1, alpha Subunit*/genetics ; Chondrocytes*/Chondrocytes*/Chondrocytes*/metabolism

• Source: PloS one [PLoS One] 2025 Apr 01; Vol. 20 (4), pp. e0319976. Date of Electronic Publication: 2025 Apr 01 (Print Publication: 2025).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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HIF1A facilitates hypoxia-induced changes in H3K27ac modification to promote myometrial contractility.

• Authors : Ji K; Guangzhou Key Laboratory of Maternal-Fetal Medicine, Institute of Reproductive Health and Perinatology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.; Wen B

Subjects: Myometrium*/Myometrium*/Myometrium*/metabolism ; Myometrium*/Myometrium*/Myometrium*/cytology ; Myometrium*/Myometrium*/Myometrium*/physiology

• Source: Communications biology [Commun Biol] 2025 Mar 21; Vol. 8 (1), pp. 475. Date of Electronic Publication: 2025 Mar 21.Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN:

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Unraveling the role of hypoxia-inducible factors in cutaneous melanoma: from mechanisms to therapeutic opportunities.

• Authors : Bellazzo, Arianna¹ (AUTHOR); Montico, Barbara¹ (AUTHOR) ; Guerrieri, Roberto¹ (AUTHOR)

• Source: Cell Communication & Signaling. 4/9/2025, Vol. 23 Issue 1, p1-19. 19p.

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Primary Cilia, Hypoxia, and Liver Dysfunction: A New Perspective on Biliary Atresia.

• Authors : Quelhas P; RISE-Health, Department of Medical Sciences, Faculty of Health Sciences, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, Portugal.; Morgado D

Subjects: Biliary Atresia*/Biliary Atresia*/Biliary Atresia*/pathology ; Biliary Atresia*/Biliary Atresia*/Biliary Atresia*/metabolism ; Biliary Atresia*/Biliary Atresia*/Biliary Atresia*/physiopathology

• Source: Cells [Cells] 2025 Apr 15; Vol. 14 (8). Date of Electronic Publication: 2025 Apr 15.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409

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Selenomethionine inhibits the proliferation of hypoxia-induced pulmonary artery smooth muscle cells by inhibiting ROS and HIF-1α-ACE-AngII axis.

• Authors : Huang T; Department of Public Health, Qinghai Unversity Medical College, Xining 810016, China.; Liu S

Subjects: Pulmonary Artery*/Pulmonary Artery*/Pulmonary Artery*/metabolism ; Pulmonary Artery*/Pulmonary Artery*/Pulmonary Artery*/cytology ; Pulmonary Artery*/Pulmonary Artery*/Pulmonary Artery*/drug effects

• Source: Scientific reports [Sci Rep] 2025 Apr 06; Vol. 15 (1), pp. 11746. Date of Electronic Publication: 2025 Apr 06.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Adaptation mechanisms in cancer: Lipid metabolism under hypoxia and nutrient deprivation as a target for novel therapeutic strategies (Review).

• Authors : Koizume S; Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama, Kanagawa 241‑8515, Japan.; Miyagi Y

Subjects: Neoplasms*/Neoplasms*/Neoplasms*/metabolism ; Neoplasms*/Neoplasms*/Neoplasms*/pathology ; Neoplasms*/Neoplasms*/Neoplasms*/therapy

• Source: Molecular medicine reports [Mol Med Rep] 2025 Apr; Vol. 31 (4). Date of Electronic Publication: 2025 Jan 31.Publisher: D. A. Spandidos Country of Publication: Greece NLM ID: 101475259 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Disparity Between Functional and Structural Recovery of Placental Mitochondria After Exposure to Hypoxia.

• Authors : Sierla JR; Division of Neonatology and Pediatric Critical Care Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; Pagerols Raluy L

Subjects: Mitochondria*/Mitochondria*/Mitochondria*/metabolism ; Mitochondria*/Mitochondria*/Mitochondria*/pathology ; Placenta*/Placenta*/Placenta*/metabolism

• Source: International journal of molecular sciences [Int J Mol Sci] 2025 Mar 25; Vol. 26 (7). Date of Electronic Publication: 2025 Mar 25.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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