نتائج البحث

Mutant huntingtin protein induces MLH1 degradation, DNA hyperexcision, and cGAS-STING-dependent apoptosis.

• Authors : Sun, Xiao; Liu, Lu; Wu, Chao

Subjects: Exo1; Huntington’s disease; MutLα

• Source: Proceedings of the National Academy of Sciences. 121(13)

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Study to Measure Cerebrospinal Fluid Mutant Huntingtin Protein in Participants With Early Manifest Stage I or Stage II Huntington's Disease

• Source: A Multi-Site, Prospective, Longitudinal, Cohort Study Measuring Cerebrospinal Fluid-Mutant Huntingtin Protein in Patients With

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Quantifying mutant huntingtin protein in human cerebrospinal fluid to support the development of huntingtin-lowering therapies.

• Authors : Vauleon, Stephanie¹ (AUTHOR); Schutz, Katharina¹ (AUTHOR); Massonnet, Benoit¹ (AUTHOR)

• Source: Scientific Reports. 4/1/2023, Vol. 13 Issue 1, p1-17. 17p.

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Salivary Huntingtin protein is uniquely associated with clinical features of Huntington's disease.

• Authors : Parkin, Georgia M; Corey-Bloom, Jody; Snell, Chase

Subjects: Humans; Huntington Disease; Salivary Proteins and Peptides

• Source: Scientific reports. 13(1)

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UBL3 Interacts with PolyQ-Expanded Huntingtin Fragments and Modifies Their Intracellular Sorting.

• Authors : Oyama, Soho¹ (AUTHOR) ; Zhang, Hengsen^1,2 (AUTHOR) ; Ferdous, Rafia¹ (AUTHOR)

• Source: Neurology International. Dec2024, Vol. 16 Issue 6, p1175-1188. 14p.

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Endothelial Dysfunction in Huntington's Disease: Pathophysiology and Therapeutic Implications.

• Authors : Hu, Ning¹ (AUTHOR) ; Chen, Zihao² (AUTHOR); Zhao, Xinyue^1,3 (AUTHOR)

Subjects: *PGC-1 protein; *HUNTINGTON disease; *BRAIN-derived neurotrophic factor

• Source: International Journal of Molecular Sciences. Feb2025, Vol. 26 Issue 4, p1432. 17p.

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Multimer Detection System: A Universal Assay System for Differentiating Protein Oligomers from Monomers.

• Authors : Jamerlan, Angelo Moscoso¹ (AUTHOR) ; Shim, Kyu Hwan¹ (AUTHOR); Sharma, Niti¹ (AUTHOR)

Subjects: *LEWY body dementia; *HUNTINGTON disease; *DNA-binding proteins

• Source: International Journal of Molecular Sciences. Feb2025, Vol. 26 Issue 3, p1199. 20p.

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Gastrodin Improves the Activity of the Ubiquitin–Proteasome System and the Autophagy–Lysosome Pathway to Degrade Mutant Huntingtin.

• Authors : Sun, He¹ (AUTHOR) ; Li, Miao¹ (AUTHOR) ; Li, Yunling² (AUTHOR)

Subjects: *HUNTINGTIN protein; *HUNTINGTON disease; *ORAL drug administration

• Source: International Journal of Molecular Sciences. Jul2024, Vol. 25 Issue 14, p7709. 16p.

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Mutant Huntingtin Protein Interaction Map Implicates Dysregulation of Multiple Cellular Pathways in Neurodegeneration of Huntington’s Disease

• Authors : Podvin, Sonia; Rosenthal, Sara Brin; Poon, William

Subjects: Biomedical and Clinical Sciences; Neurosciences; Brain Disorders

• Source: Journal of Huntington's Disease. 11(3)

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Quantifying Huntingtin Protein in Human Cerebrospinal Fluid Using a Novel Polyglutamine Length-Independent Assay.

• Authors : Fodale, Valentina¹ (AUTHOR); Pintauro, Roberta¹ (AUTHOR); Daldin, Manuel¹ (AUTHOR)

• Source: Journal of Huntington's Disease. 2022, Vol. 11 Issue 3, p291-305. 15p.

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