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Discovery of highly potent HDAC8 PROTACs with anti-tumor activity

• Authors : Zhao, Chunlong; Chen, Deng; Suo, Feng-zhi

Subjects: Humans; Repressor Proteins; Proteolysis Targeting Chimera

• Source: Zhao , C , Chen , D , Suo , F , Setroikromo , R , Quax , W J & Dekker , F 2023 , ' Discovery of highly potent HDAC8 PROTACs with anti-tumor activity ' , Bioorganic Chemistry , vol. 136 , 106546 .

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Balancing the interplay of histone deacetylases and non-coding genomes: a step closer to understand the landscape of cancer treatment.

• Authors : Pu, Jingjing; Liu, Ting; Sharma, Amit

Subjects: info:eu-repo/classification/ddc/610; Humans; Histone Deacetylases: geneticsDE

• Source: BMC medical genomics 16(1), 295 (2023). doi:10.1186/s12920-023-01724-3

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Quisinostat is a brain-penetrant radiosensitizer in glioblastoma

• Authors : Lo Cascio, Costanza; Margaryan, Tigran; Luna-Melendez, Ernesto

Subjects: Brain cancer; Drug therapy; Oncology

• Source: Translational Neuroscience

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Proinflammatory cytokines perturb mouse and human pancreatic islet circadian rhythmicity and induce uncoordinated β-cell clock gene expression via nitric oxide, lysine deacetylases, and immunoproteasomal activity

• Authors : Andersen, Phillip Alexander Keller; Petrenko, Volodymyr; Rose, Peter Horskjær

Subjects: info:eu-repo/classification/ddc/612; info:eu-repo/classification/ddc/616; ARNTL Transcription Factors/genetics/metabolism

• Source: ISSN: 1661-6596 ; International Journal of Molecular Sciences, vol. 22, no. 1 (2020) 83.

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Histone deacetylase inhibitors promote the tumoricidal effect of HAMLET.

• Authors : Brest, Patrick; Gustafsson, Mattias; Mossberg, Anki

Subjects: Histone Deacetylases: metabolism; Histones: metabolism; Histone Deacetylases: antagonists & inhibitors

• Source: Cancer Research. 67(23):11327-11334

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POWERDRESS-mediated histone deacetylation is essential for thermomorphogenesis in Arabidopsis thaliana

• Authors : Tasset, Celine; Singh Yadav, Avilash; Sureshkumar, Sridevi ...

Subjects: Acetylation; Arabidopsis/genetics; Arabidopsis Proteins/genetics

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The crystal structure of the Leishmania infantum Silent Information Regulator 2 related protein 1: Implications to protein function and drug design

• Authors : Ronin, C; Costa, DM; Tavares, J ...

Subjects: Binding Site; Crystallography; X-Ray

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Histone deacetylase 6 inhibition reduces cysts by decreasing cAMP and Ca2 in knock-out mouse models of polycystic kidney disease

• Authors : Yanda, M.K.; Liu, Q.; Cebotaru, V.

Subjects: Calcium--metabolism; Calcium Signaling--drug effects; Cyclic AMP--metabolism

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HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning.

• Authors : Ferrari, A.; Longo, R.; Fiorino, E.

Subjects: Adipocytes/physiology; Adipose Tissue; Brown/physiology

• Source: Nature Communications, vol. 8, no. 1, pp. 93

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Valproate Targets Mammalian Gastrulation Impairing Neural Tissue Differentiation and Development of the Placental Source In Vitro

• Authors : Ana Katušić-Bojanac; Milvija Plazibat; Marta Himelreich-Perić

Subjects: Placenta; Histone Deacetylases; Catalysis

• Source: International Journal of Molecular Sciences; Volume 23; Issue 16; Pages: 8861

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