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Targeting the "undruggable" cancer driver genes: Ras, myc, and tp53.

• Authors : XINGBO WU¹; DAN PAN¹; SHOUYI TANG¹

• Source: Biocell. 2023, Vol. 47 Issue 7, p1459-1472. 14p.

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LaSOM 335, active against bladder cancer cells, interferes with Let-60 (hRas) and reduces CD73 expression/activity.

• Authors : Kagami LP; Laboratório de Síntese Orgânica Medicinal - LaSOM®, Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.; Gonçalves IL

Subjects: Genes, ras* ; Urinary Bladder Neoplasms*/Urinary Bladder Neoplasms*/Urinary Bladder Neoplasms*/drug therapy ; Urinary Bladder Neoplasms*/Urinary Bladder Neoplasms*/Urinary Bladder Neoplasms*/metabolism

• Source: Chemical biology & drug design [Chem Biol Drug Des] 2023 Sep; Vol. 102 (3), pp. 536-546. Date of Electronic Publication: 2023 Jun 05.Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101262549 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Establishing the Role of Iridoids as Potential Kirsten Rat Sarcoma Viral Oncogene Homolog G12C Inhibitors Using Molecular Docking; Molecular Docking Simulation; Molecular Mechanics Poisson-Boltzmann Surface Area; Frontier Molecular Orbital Theory; Molecular Electrostatic Potential; and Absorption, Distribution, Metabolism, Excretion, and Toxicity Analysis.

• Authors : Alamri MA; Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.; Alawam AS

Subjects: Proto-Oncogene Proteins p21(ras)*/Proto-Oncogene Proteins p21(ras)*/Proto-Oncogene Proteins p21(ras)*/genetics ; Genes, ras*; Humans

• Source: Molecules (Basel, Switzerland) [Molecules] 2023 Jun 28; Vol. 28 (13). Date of Electronic Publication: 2023 Jun 28.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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An ERK1/2-driven RNA-binding switch in nucleolin drives ribosome biogenesis and pancreatic tumorigenesis downstream of RAS oncogene.

• Authors : Azman MS; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, London, UK.; Alard EL

Subjects: Genes, ras* ; Pancreatic Neoplasms*/Pancreatic Neoplasms*/Pancreatic Neoplasms*/genetics ; Pancreatic Neoplasms*/Pancreatic Neoplasms*/Pancreatic Neoplasms*/metabolism

• Source: The EMBO journal [EMBO J] 2023 Jun 01; Vol. 42 (11), pp. e110902. Date of Electronic Publication: 2023 Apr 11.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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A mutation analysis of the EGFR pathway genes, RAS, EGFR, PIK3CA, AKT1 and BRAF, and TP53 gene in thymic carcinoma and thymoma type A/B3.

• Authors : Sakane T; Department of Pathology and Molecular Diagnostics, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.; Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

Subjects: Genes, erbB-1*; Thymoma/Thymoma/Thymoma/*genetics ; Thymus Neoplasms/Thymus Neoplasms/Thymus Neoplasms/*diagnosis

• Source: Histopathology [Histopathology] 2019 Nov; Vol. 75 (5), pp. 755-766. Date of Electronic Publication: 2019 Oct 03.Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 7704136 Publication Model: Print-Electronic Cited Medium: Internet

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Análisis en biopsia líquida del estado mutacional de los genes RAS en cáncer colorrectal metastásico. Implicaciones terapéuticas

Subjects: cáncer colorrectal (CCR); RAS; KRAS

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Análisis en biopsia líquida del estado mutacional de los genes RAS en cáncer colorrectal metastásico. Implicaciones terapéuticas

Subjects: cáncer colorrectal (CCR); RAS; KRAS

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Análisis en biopsia líquida del estado mutacional de los genes RAS en cáncer colorrectal metastásico. Implicaciones terapéuticas

Subjects: cáncer colorrectal (CCR); RAS; KRAS

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Análisis en biopsia líquida del estado mutacional de los genes RAS en cáncer colorrectal metastásico. Implicaciones terapéuticas

Subjects: cáncer colorrectal (CCR); RAS; KRAS

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RAS oncogene signal strength regulates matrisomal gene expression and tumorigenicity of mouse keratinocytes.

• Authors : Cataisson C; Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.; Lee AJ

Subjects: Genes, ras* ; Cell Transformation, Neoplastic*/Cell Transformation, Neoplastic*/Cell Transformation, Neoplastic*/pathology; Mice

• Source: Carcinogenesis [Carcinogenesis] 2022 Dec 31; Vol. 43 (12), pp. 1149-1161.Publisher: Irl Press At Oxford University Press Country of Publication: England NLM ID: 8008055 Publication Model: Print Cited Medium: Internet ISSN:

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