نتائج البحث

Molecular mechanism of dynein-dynactin complex assembly by LIS1.

• Authors : Singh K; MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.; Lau CK

Subjects: Dynactin Complex*/Dynactin Complex*/Dynactin Complex*/chemistry ; Dynactin Complex*/Dynactin Complex*/Dynactin Complex*/genetics ; Dynactin Complex*/Dynactin Complex*/Dynactin Complex*/metabolism

• Source: Science (New York, N.Y.) [Science] 2024 Mar 29; Vol. 383 (6690), pp. eadk8544. Date of Electronic Publication: 2024 Mar 29.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic

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Dysregulation of stress granule dynamics by DCTN1 deficiency exacerbates TDP-43 pathology in Drosophila models of ALS/FTD.

• Authors : Ueda T; Department of Neurology, Faculty of Medicine, Kindai University, 377-2 Ohnohigashi, Osakasayama, Osaka, 589-8511, Japan.; Department of Neurotherapeutics, Osaka University Graduate School of Medicine, Osaka, 565-0871, Japan.

Subjects: Amyotrophic Lateral Sclerosis*/Amyotrophic Lateral Sclerosis*/Amyotrophic Lateral Sclerosis*/pathology ; DNA-Binding Proteins*/DNA-Binding Proteins*/DNA-Binding Proteins*/genetics ; DNA-Binding Proteins*/DNA-Binding Proteins*/DNA-Binding Proteins*/metabolism

• Source: Acta neuropathologica communications [Acta Neuropathol Commun] 2024 Feb 04; Vol. 12 (1), pp. 20. Date of Electronic Publication: 2024 Feb 04.Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960

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The structure of the dynactin complex and its interaction with dynein

• Authors : Urnavicius, Linas; Zhang, Kai; Diamant, Aristides G.

• Source: Science, 2015 Mar . 347(6229), 1441-1446.

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Lis1 relieves cytoplasmic dynein-1 autoinhibition by acting as a molecular wedge.

• Authors : Karasmanis, Eva; Reimer, Janice; Kendrick, Agnieszka

Subjects: Animals; Humans; Cytoplasmic Dyneins

• Source: Nature Structural and Molecular Biology. 30(9)

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Dynein–dynactin complex subunits are differentially localized in brain and spinal cord, with selective involvement in pathological features of neurodegenerative disease.

• Authors : Ateh, D. D.¹ ; Hussain, I. K.¹; Mustafa, A. H.¹

• Source: Neuropathology & Applied Neurobiology. Feb2008, Vol. 34 Issue 1, p88-94. 7p. 7 Color Photographs, 2 Charts.

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Dynein-dynactin complex is essential for dendritic restriction of TM1-containing Drosophila Dscam

• Authors : Yang, Jacob S.; Bai, Jia-Min; Lee, Tzumin ...

Subjects: Animals; Genetically Modified; Dendrites

• Source: PloS one ; 3 ; 10 ; e3504

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Cryo-EM reveals the complex architecture of dynactin's shoulder region and pointed end.

• Authors : Lau CK; Structural Studies Division, MRC Laboratory of Molecular Biology, Cambridge, UK.; O'Reilly FJ

Subjects: Dynactin Complex/Dynactin Complex/Dynactin Complex/*chemistry; Cryoelectron Microscopy ; Dynactin Complex/Dynactin Complex/Dynactin Complex/metabolism

• Source: The EMBO journal [EMBO J] 2021 Apr 15; Vol. 40 (8), pp. e106164. Date of Electronic Publication: 2021 Mar 18.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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DCTN1 Binds to TDP-43 and Regulates TDP-43 Aggregation.

• Authors : Deshimaru M; Department of Neurology, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, Japan.; Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, Japan.

Subjects: Protein Aggregates*; DNA-Binding Proteins/DNA-Binding Proteins/DNA-Binding Proteins/*metabolism ; Dynactin Complex/Dynactin Complex/Dynactin Complex/*metabolism

• Source: International journal of molecular sciences [Int J Mol Sci] 2021 Apr 13; Vol. 22 (8). Date of Electronic Publication: 2021 Apr 13.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Structural organization of the dynein-dynactin complex bound to microtubules.

• Authors : Chowdhury S; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, California, USA.; Ketcham SA

Subjects: Dyneins/Dyneins/Dyneins/*chemistry ; Microtubule-Associated Proteins/Microtubule-Associated Proteins/Microtubule-Associated Proteins/*chemistry ; Microtubules/Microtubules/Microtubules/*chemistry

• Source: Nature structural & molecular biology [Nat Struct Mol Biol] 2015 Apr; Vol. 22 (4), pp. 345-7. Date of Electronic Publication: 2015 Mar 09.Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Autophagy and Ubiquitin-Proteasome System Coordinate to Regulate the Protein Quality Control of Neurodegenerative Disease-Associated DCTN1.

• Authors : Wang N; Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, |Soochow University, Suzhou, 215123, Jiangsu, China.; Ma Q

Subjects: Proteolysis*; Autophagy/Autophagy/Autophagy/*physiology ; Dynactin Complex/Dynactin Complex/Dynactin Complex/*physiology

• Source: Neurotoxicity research [Neurotox Res] 2020 Jan; Vol. 37 (1), pp. 48-57. Date of Electronic Publication: 2019 Oct 25.Publisher: Springer Country of Publication: United States NLM ID: 100929017 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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