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Approach for Phased Sequence-Based Genotyping of the Critical Pharmacogene Dihydropyrimidine Dehydrogenase (DPYD).

• Authors : Ambrodji, Alisa^1,2 (AUTHOR) ; Sadlon, Angélique¹ (AUTHOR) ; Amstutz, Ursula¹ (AUTHOR)

Subjects: *DIHYDROPYRIMIDINE dehydrogenase; *GENOTYPES; *FLUOROPYRIMIDINESEUROPE

• Source: International Journal of Molecular Sciences. Jul2024, Vol. 25 Issue 14, p7599. 15p.

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Safety of Trifluridine/Tipiracil in Patients With Dihydropyrimidine Dehydrogenase Deficiency Diagnosed With Metastatic Colorectal or Gastroesophageal Cancer (TRIFLUOX-DP)

• Authors : Servier

• Source: TRIFLUOX-DP: Safety of Trifluridine/Tipiracil as Replacement of Fluoropyrimidines (5-fluorouracil and Capecitabine) Based Chemotherapy as First Line Metastatic Colorectal or Gastroesophageal Cancer

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A novel large intragenic DPYD deletion causing dihydropyrimidine dehydrogenase deficiency: a case report.

• Authors : Malekkou, Anna¹ (AUTHOR); Tomazou, Marios² (AUTHOR); Mavrikiou, Gavriella¹ (AUTHOR)

• Source: BMC Medical Genomics. 3/25/2024, Vol. 17 Issue 1, p1-10. 10p.

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Complete DPYD genotyping combined with dihydropyrimidine dehydrogenase phenotyping to prevent fluoropyrimidine toxicity: A retrospective study.

• Authors : De Metz, Côme¹ (AUTHOR); Hennart, Benjamin² (AUTHOR); Aymes, Estelle³ (AUTHOR)

• Source: Cancer Medicine. Mar2024, Vol. 13 Issue 6, p1-12. 12p.

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Relationship Between Dihydropyrimidine Dehydrogenase Gene Polymorphism and Toxicities in Cancer Patients Receiving 5-Fluorouracil.

• Authors : YÜKSEL, Tahsin¹ ; CİNDOĞLU, Çiğdem²

Subjects: *DRUG toxicity; *RETROSPECTIVE studies; *DESCRIPTIVE statistics

• Source: Forbes Journal of Medicine. 2024, Vol. 5 Issue 2, p87-94. 8p.

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Relationship Between Dihydropyrimidine Dehydrogenase Gene Polymorphism and Toxicities in Cancer Patients Receiving 5-Fluorouracil

• Authors : Tahsin YÜKSEL; Çiğdem CİNDOĞLU

Subjects: dihydropyrimidine dehydrogenase; 5-fluorouracil; gene polymorphism

• Source: Forbes Tıp Dergisi, Vol 5, Iss 2, Pp 87-94 (2024)

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Genetic Variation in miR-27a Is Associated with Fluoropyrimidine-Associated Toxicity in Patients with Dihydropyrimidine Dehydrogenase Variants after Genotype-Guided Dose Reduction.

• Authors : Medwid, Samantha^1,2 (AUTHOR) ; Wigle, Theodore J.^1,2 (AUTHOR) ; Ross, Cameron^1,2 (AUTHOR)

Subjects: *DIHYDROPYRIMIDINE dehydrogenase; *GENETIC variation; *ENZYME metabolism

• Source: International Journal of Molecular Sciences. Sep2023, Vol. 24 Issue 17, p13284. 12p.

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Improving single nucleotide polymorphisms genotyping accuracy for dihydropyrimidine dehydrogenase testing in pharmacogenetics

• Authors : Annalaura Montella; Sueva Cantalupo; Giuseppe D’Alterio

Subjects: pharmacogenetics; dihydropyrimidine dehydrogenase; genotyping

• Source: Exploration of Targeted Anti-tumor Therapy, Vol 5, Iss 2, Pp 374-383 (2024)

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Predicting Dihydropyrimidine Dehydrogenase Deficiency and Related 5-Fluorouracil Toxicity: Opportunities and Challenges of DPYD Exon Sequencing and the Role of Phenotyping Assays.

• Authors : De Luca, Ottavia¹ (AUTHOR); Salerno, Gerardo^1,2 (AUTHOR); De Bernardini, Donatella¹ (AUTHOR)

Subjects: *DIHYDROPYRIMIDINE dehydrogenase; *GLUCOSE-6-phosphate dehydrogenase; *FLUOROURACIL

• Source: International Journal of Molecular Sciences. Nov2022, Vol. 23 Issue 22, p13923. 12p.

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Poor association between dihydropyrimidine dehydrogenase (DPYD) genotype and fluoropyrimidine‐induced toxicity in an Asian population.

• Authors : Kanai, Masashi¹ (AUTHOR) ‐u.ac.jp; Kawaguchi, Takahisa² (AUTHOR); Kotaka, Masahito³ (AUTHOR)

• Source: Cancer Medicine. Apr2023, Vol. 12 Issue 7, p7808-7814. 7p.

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