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Targeting MTHFD2 to Exploit Cancer-Specific Metabolism and the DNA Damage Response

• Authors : Ramos, L; Henriksson, M; Helleday, T

Subjects: Medicin och hälsovetenskap

• Source: Cancer research. 84(1):9-16

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Gemcitabine and ATR inhibitors synergize to kill PDAC cells by blocking DNA damage response.

• Authors : Höfer, Stefanie¹ (AUTHOR); Frasch, Larissa¹ (AUTHOR); Brajkovic, Sarah¹ (AUTHOR)

• Source: Molecular Systems Biology. Mar2025, Vol. 21 Issue 3, p231-253. 23p.

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HDGF Knockout Suppresses Colorectal Cancer Progression and Drug Resistance by Modulating the DNA Damage Response.

• Authors : Su, Riya¹ (AUTHOR) ; Wang, Qin¹ (AUTHOR); Hu, Qun² (AUTHOR)

• Source: Biomolecules (2218-273X). Feb2025, Vol. 15 Issue 2, p282. 21p.

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Minichromosome Maintenance Proteins: From DNA Replication to the DNA Damage Response.

• Authors : Malysa, Agnes¹ (AUTHOR) ; Zhang, Xiaohong Mary¹ (AUTHOR); Bepler, Gerold¹ (AUTHOR)

• Source: Cells (2073-4409). Jan2025, Vol. 14 Issue 1, p12. 20p.

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IHCH9033, a novel class I HDAC inhibitor, synergizes with FLT3 inhibitor and rescues quizartinib resistance in FLT3-ITD AML via enhancing DNA damage response.

• Authors : Yao, Mingyue^1,2 (AUTHOR); Yan, Wenzhong³ (AUTHOR); Wang, Yafang² (AUTHOR)

• Source: Experimental Hematology & Oncology. 2/15/2025, Vol. 14 Issue 1, p1-19. 19p.

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Loss of Gst1 enhances resistance to MMS by reprogramming the transcription of DNA damage response genes in a Rad53-dependent manner in Candida albicans.

• Authors : Cai, Huaxin¹ (AUTHOR); Feng, Yuting^1,2 (AUTHOR); Wang, Jia¹ (AUTHOR)

• Source: Cell Communication & Signaling. 10/14/2024, Vol. 22 Issue 1, p1-18. 18p.

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CRISPR-Cas9 Knockout Screens Identify DNA Damage Response Pathways and BTK as Essential for Cisplatin Response in Diffuse Large B-Cell Lymphoma

• Authors : Issa, II; Due, H; Brondum, RF

Subjects: Medicin och hälsovetenskap

• Source: Cancers. 16(13)

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Niraparib Before Surgery in Treating Patients With High Risk Localized Prostate Cancer and DNA Damage Response Defects

• Authors : National Cancer Institute (NCI); Janssen, LP; Marc Dall'Era, MD, Principal Investigator

• Source: Phase II Trial of PARP Inhibitor Niraparib for Men With High Risk Prostate Cancer and DNA Damage Response

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A Study Investigating DNA-damage Response Agents in Molecularly Altered Advanced Cancer

• Source: A Modular Phase 2a Multicentre Open-Label Study to Investigate DNA-damage Response Agents (or Combinations)

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Metabolic Rewiring in the Face of Genomic Assault: Integrating DNA Damage Response and Cellular Metabolism.

• Authors : Ma, Wenjian^1,2 (AUTHOR) ; Zhou, Sa² (AUTHOR)

• Source: Biomolecules (2218-273X). Feb2025, Vol. 15 Issue 2, p168. 16p.

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