نتائج البحث

Unraveling the CDK9/PP2A/ERK Network in Transcriptional Pause Release and Complement Activation in KRAS-mutant Cancers.

• Authors : Wang Y; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, 393 Middle Huaxia Road, Shanghai, 201210, P. R. China.; Xu L

Subjects: Cyclin-Dependent Kinase 9*/Cyclin-Dependent Kinase 9*/Cyclin-Dependent Kinase 9*/metabolism ; Cyclin-Dependent Kinase 9*/Cyclin-Dependent Kinase 9*/Cyclin-Dependent Kinase 9*/genetics ; Proto-Oncogene Proteins p21(ras)*/Proto-Oncogene Proteins p21(ras)*/Proto-Oncogene Proteins p21(ras)*/genetics

• Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Nov; Vol. 11 (41), pp. e2404926. Date of Electronic Publication: 2024 Sep 10.Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844

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Synthesis, Cytotoxic Evaluation, and Structure-Activity Relationship of Substituted Quinazolinones as Cyclin-Dependent Kinase 9 Inhibitors.

• Authors : Alkahtani HM; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.; Zen AA

Subjects: Cyclin-Dependent Kinase 9* ; Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/chemistry; Molecular Docking Simulation

• Source: Molecules (Basel, Switzerland) [Molecules] 2022 Dec 23; Vol. 28 (1). Date of Electronic Publication: 2022 Dec 23.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Inhibition of cyclin dependent kinase 9 is synthetically lethal with the loss of von Hippel Lindau tumor suppressor in clear cell renal cell carcinoma

• Authors : Castro, Kyleen Elisabeth

Subjects: Molecular biology; Cellular biology; Oncology

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Cyclin dependent kinase 9 inhibition reduced programmed death-ligand 1 expression and improved treatment efficacy in hepatocellular carcinoma

• Authors : Yu-Yun Shao; Min-Shu Hsieh; Yi-Hsuan Lee

Subjects: Cyclin dependent kinase; Hepatocellular carcinoma; Immune checkpoints

• Source: Heliyon, Vol 10, Iss 14, Pp e34289- (2024)

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Relocalizing transcriptional kinases to activate apoptosis.

• Authors : Sarott RC; Department of Chemical and Systems Biology, Stanford University, Stanford, CA 94305, USA.; Gourisankar S

Subjects: Apoptosis*/Apoptosis*/Apoptosis*/drug effects ; Cyclin-Dependent Kinase 9*/Cyclin-Dependent Kinase 9*/Cyclin-Dependent Kinase 9*/metabolism ; Protein Kinase Inhibitors*/Protein Kinase Inhibitors*/Protein Kinase Inhibitors*/pharmacology

• Source: Science (New York, N.Y.) [Science] 2024 Oct 04; Vol. 386 (6717), pp. eadl5361. Date of Electronic Publication: 2024 Oct 04.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic

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Small molecule inhibitors of cyclin-dependent kinase 9 for cancer therapy.

• Authors : Alsfouk A; Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Cyclin-Dependent Kinase 9/Cyclin-Dependent Kinase 9/Cyclin-Dependent Kinase 9/*antagonists & inhibitors ; Protein Kinase Inhibitors/Protein Kinase Inhibitors/Protein Kinase Inhibitors/*pharmacology

• Source: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 693-706.Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print Cited Medium: Internet ISSN: 1475-6374

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Cyclin-dependent kinase 9 (CDK9) is a novel prognostic marker and therapeutic target in osteosarcoma.

• Authors : Ma, Hangzhan; Seebacher, Nicole A; Hornicek, Francis J

Subjects: Cell Line; Tumor; Humans

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Myeloid Targeted Human MLL-ENL and MLL-AF9 Induces cdk9 and bcl2 Expression in Zebrafish Embryos.

• Authors : Belt AJ; Life Sciences, Virginia Commonwealth University, Richmond, Virginia, United States of America.; Grant S

Subjects: Zebrafish*/Zebrafish*/Zebrafish*/genetics ; Zebrafish*/Zebrafish*/Zebrafish*/embryology ; Cyclin-Dependent Kinase 9*/Cyclin-Dependent Kinase 9*/Cyclin-Dependent Kinase 9*/genetics

• Source: PLoS genetics [PLoS Genet] 2024 Jun 03; Vol. 20 (6), pp. e1011308. Date of Electronic Publication: 2024 Jun 03 (Print Publication: 2024).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101239074 Publication Model: eCollection Cited Medium: Internet

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SNS-032 attenuates liver fibrosis by anti-active hepatic stellate cells via inhibition of cyclin dependent kinase 9

• Authors : Xiao-Li He; Yong-Hong Hu; Jia-Mei Chen

Subjects: liver fibrosis; hepatic stellate cell; cyclin-dependent kinase 9

• Source: Frontiers in Pharmacology, Vol 13 (2022)

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Synthesis, Cytotoxic Evaluation, and Structure-Activity Relationship of Substituted Quinazolinones as Cyclin-Dependent Kinase 9 Inhibitors.

• Authors : Alkahtani, Hamad M.¹ (AUTHOR) ; Zen, Amer Alhaj² (AUTHOR); Obaidullah, Ahmad J.¹ (AUTHOR)

Subjects: *CYCLIN-dependent kinase inhibitors; *QUINAZOLINONES; *STRUCTURE-activity relationships

• Source: Molecules. Jan2023, Vol. 28 Issue 1, p120. 16p.

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