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Safety and Efficacy of PD0332991 (Palbociclib), a Cyclin-dependent Kinase 4 and 6 Inhibitor, in Patients With Oligodendroglioma or Recurrent Oligoastrocytoma Anaplastic With the Activity of the Protein RB Preserved

• Authors : Pfizer

• Source: Phase II Pilot, Prospective, Open Label, Multicenter CT, to Evaluate the Safety and Efficacy of Palbociclib (PD0332991), a Cyclin-

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Phase II Study of REPotrectinib With or Without Fulvestrant in Patients With Hormone Receptor-positive Human Epidermal Growth Factor 2-negative Metastatic Invasive LObular Carcinoma Who Received a Prior Endocrine Therapy in Combination With Cyclin-dependent Kinase 4 and 6 Inhibitor (REPLOT Trial)

• Source: Phase II Study of REPotrectinib With or Without Fulvestrant in Patients With Hormone Receptor-positive Human Epidermal Growth Factor 2-negative Metastatic Invasive LObular Carcinoma Who Received a

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Effectiveness of cyclin-dependent kinase 4 and 6 inhibitors for the treatment of hormonesensitive HER2-negative metastatic breast cancer in first-line therapy: A systematic literature review

• Authors : N. A. Avxentyev; I. I. Andreyashkina; E. V. Artamonova

Subjects: breast cancer; cyclin-dependent kinase 4 and 6 inhibitors; abemaciclib

• Source: Опухоли женской репродуктивной системы, Vol 20, Iss 1, Pp 64-81 (2024)

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An Activity-Based Oxaziridine Platform for Identifying and Developing Covalent Ligands for Functional Allosteric Methionine Sites: Redox-Dependent Inhibition of Cyclin-Dependent Kinase 4

• Authors : Gonzalez-Valero, Angel; Reeves, Audrey G; Page, Annika CS

Subjects: Medicinal and Biomolecular Chemistry; Chemical Sciences; Cancer

• Source: Journal of the American Chemical Society. 144(50)

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Cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i): Mechanisms of resistance and where to find them

• Authors : L. Foffano; L. Cucciniello; E. Nicolò

Subjects: Metastatic breast cancer; CDK 4/6 inhibitors resistance; Liquid biopsy

• Source: Breast, Vol 79, Iss , Pp 103863- (2025)

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CDK4/6 inhibitors upregulate cIAP1/2, and Smac mimetic LCL161 enhances their antitumor effects in cholangiocarcinoma cells.

• Authors : Menapree P; Graduate Program in Clinical Biochemistry and Molecular Medicine, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.; Duangthim N

Subjects: Cholangiocarcinoma*/Cholangiocarcinoma*/Cholangiocarcinoma*/drug therapy ; Cholangiocarcinoma*/Cholangiocarcinoma*/Cholangiocarcinoma*/metabolism ; Cholangiocarcinoma*/Cholangiocarcinoma*/Cholangiocarcinoma*/pathology

• Source: Scientific reports [Sci Rep] 2025 Feb 25; Vol. 15 (1), pp. 6826. Date of Electronic Publication: 2025 Feb 25.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Single-cell RNA sequencing identifies molecular biomarkers predicting late progression to CDK4/6 inhibition in patients with HR+/HER2- metastatic breast cancer.

• Authors : Luo L; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. .; Yang P

Subjects: Breast Neoplasms*/Breast Neoplasms*/Breast Neoplasms*/drug therapy ; Breast Neoplasms*/Breast Neoplasms*/Breast Neoplasms*/pathology ; Breast Neoplasms*/Breast Neoplasms*/Breast Neoplasms*/genetics

• Source: Molecular cancer [Mol Cancer] 2025 Feb 15; Vol. 24 (1), pp. 48. Date of Electronic Publication: 2025 Feb 15.Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598

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CDK6-Dependent, CDK4-Independent Synovial Hyperplasia in Arthritic Mice and Tumor Necrosis Factor-α-Induced Proliferation of Synovial Fibroblasts.

• Authors : Komatsu R; Institute of Medical Science, St. Marianna University School of Medicine, Kawasaki 216-8512, Kanagawa, Japan.; Fujii R

Subjects: Cyclin-Dependent Kinase 6*/Cyclin-Dependent Kinase 6*/Cyclin-Dependent Kinase 6*/metabolism ; Cyclin-Dependent Kinase 6*/Cyclin-Dependent Kinase 6*/Cyclin-Dependent Kinase 6*/genetics ; Cyclin-Dependent Kinase 4*/Cyclin-Dependent Kinase 4*/Cyclin-Dependent Kinase 4*/metabolism

• Source: International journal of molecular sciences [Int J Mol Sci] 2025 Jan 28; Vol. 26 (3). Date of Electronic Publication: 2025 Jan 28.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Identification of novel cyclin-dependent kinase 4/6 inhibitors from marine natural products.

• Authors : Debnath A; Noida Institute of Engineering and Technology [Pharmacy Institute], Institutional Area, Greater Noida, Uttar Pradesh, India.; Mazumder R

Subjects: Cyclin-Dependent Kinase 4*/Cyclin-Dependent Kinase 4*/Cyclin-Dependent Kinase 4*/antagonists & inhibitors ; Cyclin-Dependent Kinase 4*/Cyclin-Dependent Kinase 4*/Cyclin-Dependent Kinase 4*/metabolism ; Cyclin-Dependent Kinase 4*/Cyclin-Dependent Kinase 4*/Cyclin-Dependent Kinase 4*/chemistry

• Source: PloS one [PLoS One] 2025 Jan 15; Vol. 20 (1), pp. e0313830. Date of Electronic Publication: 2025 Jan 15 (Print Publication: 2025).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Inhibition of METTL14 overcomes CDK4/6 inhibitor resistance driven by METTL14-m6A-E2F1-axis in ERα-positive breast cancer.

• Authors : Liu C; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, 169 Changle West Road, 710032, Xi'an, People's Republic of China.; Department of Occupational and Environmental Health, The Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, The Fourth Military Medical University, 710032, Xi'an, People's Republic of China.

Subjects: Breast Neoplasms*/Breast Neoplasms*/Breast Neoplasms*/drug therapy ; Breast Neoplasms*/Breast Neoplasms*/Breast Neoplasms*/metabolism ; Breast Neoplasms*/Breast Neoplasms*/Breast Neoplasms*/genetics

• Source: Journal of nanobiotechnology [J Nanobiotechnology] 2025 Jan 03; Vol. 23 (1), pp. 3. Date of Electronic Publication: 2025 Jan 03.Publisher: BioMed Central Country of Publication: England NLM ID: 101152208 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-3155

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