نتائج البحث

Genetic coding variant in complement factor B (CFB) is associated with increased risk for perianal Crohns disease and leads to impaired CFB cleavage and phagocytosis.

• Authors : Akhlaghpour, Marzieh; Haritunians, Talin; More, Shyam

Subjects: IBD - GENETICS; INFLAMMATORY BOWEL DISEASE; META-ANALYSIS

• Source: Gut. 72(11)

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A Study to Evaluate the Effectiveness and Safety of IONIS-FB-LRx, an Antisense Inhibitor of Complement Factor B, in Adult Participants With Primary IgA Nephropathy

• Source: An Open-Label Phase 2a Clinical Study to Evaluate the Effectiveness and Safety of IONIS-FB-LRx, an Antisense Inhibitor of Complement

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Complement factor B inhibitor LNP023 mediates the effect and mechanism of AMPK/mTOR on autophagy and oxidative stress in lupus nephritis

• Authors : Xi‐Mei Zhang; Ming‐Jie Qing; Xin‐Kuo Liu

Subjects: AMPK/mTOR; autophagy; LNP023

• Source: Kaohsiung Journal of Medical Sciences, Vol 40, Iss 11, Pp 996-1005 (2024)

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Prognostic value of serum complement cleavage factor Bb in idiopathic membranous nephropathy and establishment of nomogram model.

• Authors : Wen L; Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. .; Li Q

Subjects: Glomerulonephritis, Membranous*/Glomerulonephritis, Membranous*/Glomerulonephritis, Membranous*/blood ; Glomerulonephritis, Membranous*/Glomerulonephritis, Membranous*/Glomerulonephritis, Membranous*/pathology ; Glomerulonephritis, Membranous*/Glomerulonephritis, Membranous*/Glomerulonephritis, Membranous*/diagnosis

• Source: Scientific reports [Sci Rep] 2024 Nov 08; Vol. 14 (1), pp. 27266. Date of Electronic Publication: 2024 Nov 08.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Modulators of Complement Factor B

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Complement factor B is essential for the proper function of the peripheral auditory system

• Authors : LaShardai N. Brown; Jeremy L. Barth; Shabih Jafri

Subjects: cochlea; complement factor B; macrophage

• Source: Frontiers in Neurology, Vol 14 (2023)

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Complement factor B regulates cellular senescence and is associated with poor prognosis in pancreatic cancer.

• Authors : Shimazaki R; Department of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba-shi, Chiba, 260- 8677, Japan.; Takano S

Subjects: RNA Interference*; Carcinoma, Pancreatic Ductal/Carcinoma, Pancreatic Ductal/Carcinoma, Pancreatic Ductal/*genetics ; Cellular Senescence/Cellular Senescence/Cellular Senescence/*genetics

• Source: Cellular oncology (Dordrecht) [Cell Oncol (Dordr)] 2021 Aug; Vol. 44 (4), pp. 937-950. Date of Electronic Publication: 2021 Jun 01.Publisher: Springer Country of Publication: Netherlands NLM ID: 101552938 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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MACROCYCLE COMPLEMENT FACTOR B INHIBITORS

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Complement factor B (CFB) iRNA compositions and methods of use thereof

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A non-synonymous variant rs12614 of complement factor B associated with risk of chronic hepatitis B in a Korean population.

• Authors : Seo JY; Current address: Department of Core Technology, R&D Center, LG Household & Healthcare (LG H&H), Seoul, 07795, South Korea.; Department of Life Science, Sogang University, Seoul, 04107, Republic of Korea.

Subjects: Exons* ; Genetic Predisposition to Disease* ; Polymorphism, Single Nucleotide*

• Source: BMC medical genetics [BMC Med Genet] 2020 Dec 17; Vol. 21 (1), pp. 241. Date of Electronic Publication: 2020 Dec 17.Publisher: BioMed Central Country of Publication: England NLM ID: 100968552 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2350

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