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Academic Journal

Comparison of a novel potentiator of CFTR channel activity to ivacaftor in ameliorating mucostasis caused by cigarette smoke in primary human bronchial airway epithelial cells.

Authors : Tanjala AC; Program in Molecular Medicine, Research Institute, Hospital for Sick Children, Toronto, Canada.; Jiang JX

Subjects: Cystic Fibrosis Transmembrane Conductance Regulator*/Cystic Fibrosis Transmembrane Conductance Regulator*/Cystic Fibrosis Transmembrane Conductance Regulator*/metabolism ; Cystic Fibrosis Transmembrane Conductance Regulator*/Cystic Fibrosis Transmembrane Conductance Regulator*/Cystic Fibrosis Transmembrane Conductance Regulator*/genetics ; Quinolones*/Quinolones*/Quinolones*/pharmacology

Source: Respiratory research [Respir Res] 2024 Jul 10; Vol. 25 (1), pp. 269. Date of Electronic Publication: 2024 Jul 10.Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101090633 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Efficacy and safety of lubiprostone for the treatment of functional constipation in Chinese adult patients: A multicenter, randomized, double-blind, placebo-controlled trial.

Authors : Xiao YL; Department of Gastroenterology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China.; Dai N

Subjects: Chloride Channel Agonists*/Chloride Channel Agonists*/Chloride Channel Agonists*/adverse effects ; Constipation*/Constipation*/Constipation*/drug therapy; Adult

Source: Journal of digestive diseases [J Dig Dis] 2021 Nov; Vol. 22 (11), pp. 622-629.Publisher: Blackwell Pub. Asia Country of Publication: Australia NLM ID: 101302699 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Ex vivo model predicted in vivo efficacy of CFTR modulator therapy in a child with rare genotype.

Authors : Terlizzi V; Cystic Fibrosis Regional Reference Center,, Department of Paediatric Medicine, Anna Meyer Children's University, Florence, Italy.; Amato F

Subjects: Genotype*; Aminophenols/Aminophenols/Aminophenols/*therapeutic use ; Aminopyridines/Aminopyridines/Aminopyridines/*therapeutic use

Source: Molecular genetics & genomic medicine [Mol Genet Genomic Med] 2021 Apr; Vol. 9 (4), pp. e1656. Date of Electronic Publication: 2021 Mar 13.Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101603758 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

From Ivacaftor to Triple Combination: A Systematic Review of Efficacy and Safety of CFTR Modulators in People with Cystic Fibrosis.

Authors : Gramegna A; Department of Pathophysiology and Transplantation, University of Milano, 20129 Milano, Italy.; Respiratory Disease and Adult Cystic Fibrosis Center, Internal Medicine Department, Fondazione IRCCS Ca' Granda, Ospedale Maggiore, Policlinico, 20129 Milano, Italy.

Subjects: Clinical Trials as Topic*; Aminophenols/Aminophenols/Aminophenols/*therapeutic use ; Chloride Channel Agonists/Chloride Channel Agonists/Chloride Channel Agonists/*therapeutic use

Source: International journal of molecular sciences [Int J Mol Sci] 2020 Aug 16; Vol. 21 (16). Date of Electronic Publication: 2020 Aug 16.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Short Chain Fatty Acids Effect on Chloride Channel ClC-2 as a Possible Mechanism for Lubiprostone Intestinal Action.

Authors : Catalán MA; Centro de Estudios Científicos (CECs), Avenida Arturo Prat 514, Valdivia 5110466, Chile.; Instituto de Fisiología, Facultad de Medicina, Universidad Austral de Chile, Valdivia 5090000, Chile.

Subjects: Chloride Channel Agonists/Chloride Channel Agonists/Chloride Channel Agonists/*therapeutic use ; Chloride Channels/Chloride Channels/Chloride Channels/*drug effects ; Fatty Acids, Volatile/Fatty Acids, Volatile/Fatty Acids, Volatile/*metabolism

Source: Cells [Cells] 2020 Jul 26; Vol. 9 (8). Date of Electronic Publication: 2020 Jul 26.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409

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Report

Response to lubiprostone in chronic constipation is associated with increased mucus and mucin output: a randomized clinical trial.

Authors : Tarasiuk A; Department of Biochemistry, Medical University of Lodz, Lodz, Poland.; Milad M

Subjects: Chloride Channel Agonists/Chloride Channel Agonists/Chloride Channel Agonists/*administration & dosage ; Constipation/Constipation/Constipation/*drug therapy ; Defecation/Defecation/Defecation/*drug effects

Source: Journal of gastrointestinal and liver diseases : JGLD [J Gastrointestin Liver Dis] 2019 Sep 01; Vol. 28 (3), pp. 263-264. Date of Electronic Publication: 2019 Sep 01.Publisher:

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Academic Journal

Structural identification of a hotspot on CFTR for potentiation.

Authors : Liu F; Laboratory of Membrane Biophysics and Biology, The Rockefeller University, New York, NY 10065, USA.; Tri-Institutional Training Program in Chemical Biology, The Rockefeller University, New York, NY 10065, USA.

Subjects: Aminophenols/Aminophenols/Aminophenols/*chemistry ; Chloride Channel Agonists/Chloride Channel Agonists/Chloride Channel Agonists/*chemistry ; Cystic Fibrosis Transmembrane Conductance Regulator/Cystic Fibrosis Transmembrane Conductance Regulator/Cystic Fibrosis Transmembrane Conductance Regulator/*chemistry

Source: Science (New York, N.Y.) [Science] 2019 Jun 21; Vol. 364 (6446), pp. 1184-1188.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium:

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Academic Journal

In-vitro evaluation of a ciprofloxacin- and ivacaftor-coated sinus stent against Pseudomonas aeruginosa biofilms.

Authors : Cho DY; Department of Otolaryngology-Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, AL.; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL.

Subjects: Aminophenols/Aminophenols/Aminophenols/*administration & dosage ; Anti-Bacterial Agents/Anti-Bacterial Agents/Anti-Bacterial Agents/*administration & dosage ; Chloride Channel Agonists/Chloride Channel Agonists/Chloride Channel Agonists/*administration & dosage

Source: International forum of allergy & rhinology [Int Forum Allergy Rhinol] 2019 May; Vol. 9 (5), pp. 486-492. Date of Electronic Publication: 2019 Jan 31.Publisher: Published for ARS-AAOA by Wiley-Blackwell Country of Publication: United States NLM ID: 101550261 Publication Model: Print-Electronic Cited

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Academic Journal

Lubiprostone improves intestinal permeability in humans, a novel therapy for the leaky gut: A prospective randomized pilot study in healthy volunteers.

Authors : Kato T; Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan.; Honda Y

Subjects: Chloride Channel Agonists/Chloride Channel Agonists/Chloride Channel Agonists/*therapeutic use ; Irritable Bowel Syndrome/Irritable Bowel Syndrome/Irritable Bowel Syndrome/*drug therapy ; Lubiprostone/Lubiprostone/Lubiprostone/*therapeutic use

Source: PloS one [PLoS One] 2017 Apr 14; Vol. 12 (4), pp. e0175626. Date of Electronic Publication: 2017 Apr 14 (Print Publication: 2017).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

CFTR modulator therapy for cystic fibrosis caused by the rare c.3700A>G mutation

Authors : Phuan, Puay-Wah; Haggie, Peter M; Tan, Joseph A

Subjects: Medical Physiology; Biomedical and Clinical Sciences; Cystic Fibrosis

Source: Journal of Cystic Fibrosis. 20(3)

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فلترة النتائج

Comparison of a novel potentiator of CFTR channel activity to ivacaftor in ameliorating mucostasis caused by cigarette smoke in primary human bronchial airway epithelial cells.

Efficacy and safety of lubiprostone for the treatment of functional constipation in Chinese adult patients: A multicenter, randomized, double-blind, placebo-controlled trial.

Ex vivo model predicted in vivo efficacy of CFTR modulator therapy in a child with rare genotype.

From Ivacaftor to Triple Combination: A Systematic Review of Efficacy and Safety of CFTR Modulators in People with Cystic Fibrosis.

Short Chain Fatty Acids Effect on Chloride Channel ClC-2 as a Possible Mechanism for Lubiprostone Intestinal Action.

Response to lubiprostone in chronic constipation is associated with increased mucus and mucin output: a randomized clinical trial.

Structural identification of a hotspot on CFTR for potentiation.

In-vitro evaluation of a ciprofloxacin- and ivacaftor-coated sinus stent against Pseudomonas aeruginosa biofilms.

Lubiprostone improves intestinal permeability in humans, a novel therapy for the leaky gut: A prospective randomized pilot study in healthy volunteers.

CFTR modulator therapy for cystic fibrosis caused by the rare c.3700A>G mutation

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