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Structure-Guided Design of a Highly Potent Partial RXR Agonist with Superior Physicochemical Properties

• Authors : Lewandowski, Max; Carmina, Melania; Merk, Daniel

Subjects: info:eu-repo/classification/ddc/610DE

• Source: Journal of medicinal chemistry 67(3), 2152 - 2164 (2024). doi:10.1021/acs.jmedchem.3c02095

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DARPins detect the formation of hetero-tetramers of p63 and p73 in epithelial tissues and in squamous cell carcinoma

• Authors : Strubel, Alexander; Münick, Philipp; Hartmann, Oliver

Subjects: Department of Biochemistry; 610 Medicine & health; 570 Life sciences

• Source: Strubel, Alexander; Münick, Philipp; Hartmann, Oliver; Chaikuad, Apirat; Dreier, Birgit; Schaefer, Jonas V; Gebel, Jakob; Osterburg,

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Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain

• Authors : Kramer, Jan S; Woltersdorf, Stefano; Duflot, Thomas

Subjects: Pharmacology and Pharmaceutical Sciences; Biomedical and Clinical Sciences; Animals

• Source: Journal of Medicinal Chemistry. 62(18)

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Oxazolo[5,4-f]quinoxaline-type selective inhibitors of glycogen synthase kinase-3α (GSK-3α): Development and impact on temozolomide treatment of glioblastoma cells

• Authors : Hasyeoui, Mohamed; Lassagne, Frédéric; Erb, William ...

Subjects: GSK-3α; Oxazolo[5; 4-f]quinoxaline

• Source: ISSN: 0045-2068.

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DESIGN, SYNTHESIS AND CHARACTERISATION OF A NOVEL TYPE II B-RAF PARADOX BREAKER INHIBITOR

• Authors : Arora, Rohit; Linders, Joannes T.M.; Aci-Sèche, Samia ...

Subjects: B-Raf kinase inhibition; Paradox breaker; phenyl(1H-pyrrolo[2

• Source: ISSN: 0223-5234.

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Targeting the Alternative Vitamin E Metabolite Binding Site Enables Noncanonical PPARγ Modulation

• Authors : Arifi, Silvia; Marschner, Julian Aurelio; Pollinger, Julius

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Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis

• Authors : Bashore, Frances M.; Marquez, Ariana B.; Chaikuad, Apirat ...

• Source: Scientific Reports ; volume 13, issue 1 ; ISSN 2045-2322

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Designed Ankyrin Repeat Proteins as a tool box for analyzing p63

• Authors : Strubel, Alexander; Münick, Philipp; Chaikuad, Apirat

Subjects: Department of Biochemistry; 570 Life sciences; biology

• Source: Strubel, Alexander; Münick, Philipp; Chaikuad, Apirat; Dreier, Birgit; Schaefer, Jonas; Gebel, Jakob; Osterburg, Christian; Tuppi,

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TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy

• Authors : Nozal, Vanesa; Martínez-González, Loreto; Gomez-Almeria, Marta ...

Subjects: ALS; TDP-43; Tau-Tubulin kinase (TTBK1)

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A consensus compound/bioactivity dataset for data-driven drug design and chemogenomics

• Authors : Isigkeit, Laura; Chaikuad, Apirat; Merk, Daniel

Subjects: ddc:540

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