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Design and synthesis of formononetin-dithiocarbamate hybrids that inhibit growth and migration of PC-3 cells via MAPK/Wnt signaling pathways.

• Authors : Fu, Dong-Jun; Zhang, Li; Song, Jian

Subjects: Antineoplastic Agents: chemical synthesis; chemistry; pharmacology

• Source: European journal of medicinal chemistry. 127

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Reprogramming of nucleotide metabolism by interferon confers dependence on the replication stress response pathway in pancreatic cancer cells

• Authors : Evan R Abt; Thuc M Le; Amanda M Dann

Subjects: Adenocarcinoma / metabolism; Adenocarcinoma / pathology; Animals

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A novel ligand of the translationally controlled tumor protein (TCTP) identified by virtual drug screening for cancer differentiation therapy

• Authors : Fischer, Nicolas; Seo, Ean-Jeong; Abdelfatah, Sara

Subjects: Dose-Response Relationship; Drug [MeSH]; Molecular Docking Simulation [MeSH]

• Source: http://lobid.org/resources/99370674913906441#!, 39(4):914-927.

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Novel chemotherapeutic agent FX-9 activates NF-κB signaling and induces G1 phase arrest by activating CDKN1A in a human prostate cancer cell line

• Authors : Weiner, F.; Schille, J. T.; Koczan, D.

Subjects: Isoquinolines/pharmacology [MeSH]; S Phase Cell Cycle Checkpoints [MeSH]; Antineoplastic Agents/pharmacology [MeSH]

• Source: http://lobid.org/resources/99370673697106441#!, 21(1):1088.

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Dichloroacetate and PX-478 exhibit strong synergistic effects in a various number of cancer cell lines

• Authors : Parczyk, Jonas; Ruhnau, Jérôme; Pelz, Carsten

Subjects: HIF-1α inhibition; Drug combination; Cell Line

• Source: http://lobid.org/resources/99370673697106441#!, 21(1):481.

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Antagonizing the spindle assembly checkpoint silencing enhances paclitaxel and Navitoclax-mediated apoptosis with distinct mechanistic

• Authors : Henriques, AC; Silva, PMA; Sarmento, B ...

Subjects: A549 Cells; Adaptor Proteins; Signal Transducing / drug effects

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PARP inhibitors combined with ionizing radiation induce different effects in melanoma cells and healthy fibroblasts

• Authors : Weigert, Verena; Jost, Tina; Hecht, Markus

Subjects: Melanoma/therapy [MeSH]; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology [MeSH]; Homologous Recombination/drug effects [MeSH]

• Source: http://lobid.org/resources/99370673697106441#!, 20(1):775.

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Synergistic Antitumor Effects of Combined Treatment with HSP90 Inhibitor and PI3K/mTOR Dual Inhibitor in Cisplatin-Resistant Human Bladder Cancer Cells

• Authors : Hyung Joon Kim; Mi Kyung Gong; Cheol Yong Yoon

Subjects: Antineoplastic Agents / therapeutic use; Antineoplastic Combined Chemotherapy Protocols; Apoptosis / drug effects

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Fadraciclib (CYC065), a novel CDK inhibitor, targets key pro-survival and oncogenic pathways in cancer

• Authors : Frame, Sheelagh; Saladino, Chiara; MacKay, Craig

Subjects: Adenosine/analogs & derivatives; Animals; Antineoplastic Agents/pharmacology

• Source: Frame , S , Saladino , C , MacKay , C , Atrash , B , Sheldrake , P , McDonald , E , Clarke , P A , Workman , P , Blake , D & Zheleva , D 2020 , ' Fadraciclib (CYC065), a novel CDK inhibitor, targets

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FZD5 (frizzled class receptor 5)

• Authors : Esposito, Ilaria; Department of Health Sciences, University of Milan, via A. Di Rudinò, 8 20142, Milan

Subjects: Wnt signalling pathway; FZD5; Frizzled

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