نتائج البحث

Positional specialization of LIR motifs in RavZ and the autophagy-related protein ATG4B

• Authors : Sang-Won Park; Jin-A Lee; Deok-Jin Jang

Subjects: Autophagy; LC3/GABARAP; ATG4B

• Source: Autophagy Reports, Vol 4, Iss 1 (2025)

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Tracking protein kinase targeting advances: integrating QSAR into machine learning for kinase-targeted drug discovery

• Authors : Rand Shahin; Sawsan Jaafreh; Yusra Azzam

Subjects: QSAR; kinase; FDA approved

• Source: Future Science OA, Vol 11, Iss 1 (2025)

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Exosomal circ_0006896 promotes AML progression via interaction with HDAC1 and restriction of antitumor immunity.

• Authors : Can, Can¹ (AUTHOR); Yang, Xinyu^1,2 (AUTHOR); Jia, Hexiao¹ (AUTHOR)

Subjects: *FLUORESCENCE in situ hybridization; *MEDICAL sciences; *ACUTE myeloid leukemia

• Source: Molecular Cancer. Dec2025, Vol. 24 Issue 1, p1-22. 22p.

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K36-based inhibitor analogs as potential therapeutics against SARS-CoV-2 main protease (Mpro): a computational investigation.

• Authors : AbouYoussef ML; Institute of Nanoscience and Nanotechnology, Kafrelshiekh University, Kafrelskiekh, 33516, Egypt.; Aboelnga MM

Subjects: SARS-CoV-2*/SARS-CoV-2*/SARS-CoV-2*/enzymology ; SARS-CoV-2*/SARS-CoV-2*/SARS-CoV-2*/drug effects ; Coronavirus 3C Proteases*/Coronavirus 3C Proteases*/Coronavirus 3C Proteases*/antagonists & inhibitors

• Source: Scientific reports [Sci Rep] 2025 Jun 23; Vol. 15 (1), pp. 20260. Date of Electronic Publication: 2025 Jun 23.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Mechanism of release factor-mediated peptidyl-tRNA hydrolysis on the ribosome.

• Authors : Aleksandrova EV; Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL, USA.; Syroegin EA

Subjects: Ribosomes*/Ribosomes*/Ribosomes*/chemistry ; Ribosomes*/Ribosomes*/Ribosomes*/metabolism ; RNA, Transfer, Amino Acyl*/RNA, Transfer, Amino Acyl*/RNA, Transfer, Amino Acyl*/chemistry

• Source: Science (New York, N.Y.) [Science] 2025 Jun 19; Vol. 388 (6753), pp. eads9030. Date of Electronic Publication: 2025 Jun 19.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic

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PHD3-VHL axis controls HIV-2 infection through oxygen-dependent hydroxylation and degradation of Vpx.

• Authors : Miyakawa K; AIDS Research Center, National Institute of Infectious Diseases, Japan Institute for Health Security, Tokyo, Japan.; Influenza Research Center, National Institute of Infectious Diseases, Japan Institute for Health Security, Tokyo, Japan.

• Source: PLoS pathogens [PLoS Pathog] 2025 Jun 16; Vol. 21 (6), pp. e1013241. Date of Electronic Publication: 2025 Jun 16.Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: Print-Electronic Cited Medium: Internet

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Evolutionary-scale enzymology enables exploration of a rugged catalytic landscape.

• Authors : Muir DF; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.; Program in Biophysics, University of California, San Francisco, San Francisco, CA, USA.

Subjects: Adenylate Kinase*/Adenylate Kinase*/Adenylate Kinase*/chemistry ; Adenylate Kinase*/Adenylate Kinase*/Adenylate Kinase*/classification ; Adenylate Kinase*/Adenylate Kinase*/Adenylate Kinase*/genetics

• Source: Science (New York, N.Y.) [Science] 2025 Jun 12; Vol. 388 (6752), pp. eadu1058. Date of Electronic Publication: 2025 Jun 12.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic

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Cat1 forms filament networks to degrade NAD + during the type III CRISPR-Cas antiviral response.

• Authors : Baca CF; Laboratory of Bacteriology, The Rockefeller University, New York, NY, USA.; Tri-Institutional PhD Program in Chemical Biology, Weill Cornell Medical College, Rockefeller University and Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Subjects: CRISPR-Associated Proteins*/CRISPR-Associated Proteins*/CRISPR-Associated Proteins*/chemistry ; CRISPR-Associated Proteins*/CRISPR-Associated Proteins*/CRISPR-Associated Proteins*/metabolism ; CRISPR-Associated Proteins*/CRISPR-Associated Proteins*/CRISPR-Associated Proteins*/genetics

• Source: Science (New York, N.Y.) [Science] 2025 Jun 12; Vol. 388 (6752), pp. eadv9045. Date of Electronic Publication: 2025 Jun 12.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic

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ZAM-CS, a novel chimeric endolysin with enhanced stability and rapid action against methicillin-resistant Staphylococcus aureus.

• Authors : Ahmadbeigi Y; Department of Microbiology and Microbial Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran.; Soleimani N

Subjects: Endopeptidases*/Endopeptidases*/Endopeptidases*/pharmacology ; Endopeptidases*/Endopeptidases*/Endopeptidases*/genetics ; Endopeptidases*/Endopeptidases*/Endopeptidases*/chemistry

• Source: BMC microbiology [BMC Microbiol] 2025 Jun 07; Vol. 25 (1), pp. 357. Date of Electronic Publication: 2025 Jun 07.Publisher: BioMed Central Country of Publication: England NLM ID: 100966981 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2180

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Conserved domains and structural motifs that differentiate closely related Rex1 and Rex3 DEDDh exoribonucleases are required for their function in yeast.

• Authors : Daniels PW; School of Biosciences, The University of Sheffield, Sheffield, United Kingdom.; Kelly S

Subjects: Saccharomyces cerevisiae*/Saccharomyces cerevisiae*/Saccharomyces cerevisiae*/enzymology ; Saccharomyces cerevisiae*/Saccharomyces cerevisiae*/Saccharomyces cerevisiae*/genetics ; Saccharomyces cerevisiae*/Saccharomyces cerevisiae*/Saccharomyces cerevisiae*/metabolism

• Source: PloS one [PLoS One] 2025 Jun 02; Vol. 20 (6), pp. e0321120. Date of Electronic Publication: 2025 Jun 02 (Print Publication: 2025).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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