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An open-label study to explore the optimal design of CYP3A drug-drug interaction clinical trials in healthy Chinese people.

• Authors : Chen J; Research Ward, Beijing Friendship Hospital, Capital Medical University, Beijing, China.; Li J

Subjects: Drug Interactions* ; Midazolam*/Midazolam*/Midazolam*/pharmacokinetics ; Midazolam*/Midazolam*/Midazolam*/administration & dosage

• Source: Pharmacology research & perspectives [Pharmacol Res Perspect] 2024 Aug; Vol. 12 (4), pp. e1252.Publisher: John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States

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DNA Methylation in the CYP3A Distal Regulatory Region (DRR) Is Associated with the Expression of CYP3A5 and CYP3A7 in Human Liver Samples.

• Authors : Collins, Joseph M.¹ (AUTHOR) ; Wang, Danxin¹ (AUTHOR)

Subjects: *INDUCED pluripotent stem cells; *LIVER enzymes; *GENE expression

• Source: Molecules. Nov2024, Vol. 29 Issue 22, p5407. 14p.

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Applications of the Cholesterol Metabolite, 4β-Hydroxycholesterol, as a Sensitive Endogenous Biomarker for Hepatic CYP3A Activity Evaluated within a PBPK Framework.

• Authors : Karkhanis, Aneesh V.¹ (AUTHOR) ; Harwood, Matthew D.¹ (AUTHOR); Stader, Felix¹ (AUTHOR)

• Source: Pharmaceutics. Oct2024, Vol. 16 Issue 10, p1284. 22p.

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Mutation types of CYP3A enzymes and sex differences in sufentanil metabolism

• Authors : JIANG Ying; QIN Zhigang; FENG Liyuan

Subjects: ‍sex differences; cyp3a; sufentanil

• Source: 陆军军医大学学报, Vol 47, Iss 6, Pp 581-590 (2025)

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Dose-dependent induction of CYP3A activity by St. John's wort alone and in combination with rifampin.

• Authors : Hohmann N; Department of Clinical Pharmacology and Pharmacoepidemiology, Internal Medicine IX, Medical Faculty of Heidelberg, Heidelberg University Hospital, University of Heidelberg, Heidelberg, Germany.; Friedrichs AS

Subjects: Rifampin*/Rifampin*/Rifampin*/administration & dosage ; Rifampin*/Rifampin*/Rifampin*/pharmacology ; Hypericum*/Hypericum*/Hypericum*/chemistry

• Source: Clinical and translational science [Clin Transl Sci] 2024 Aug; Vol. 17 (8), pp. e70007.Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN:

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High-throughput assay to simultaneously evaluate activation of CYP3A and the direct and time-dependent inhibition of CYP3A, CYP2C9, and CYP2D6 using liquid chromatography-tandem mass spectrometry.

• Authors : Yumoto, Yu¹ (AUTHOR) ; Endo, Takuro¹ (AUTHOR); Harada, Hiroshi¹ (AUTHOR)

• Source: Xenobiotica. Feb2024, Vol. 54 Issue 2, p45-56. 12p.

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Evaluation of the usefulness of plasma 4β‐hydroxycholesterol concentration normalized by 4α‐hydroxycholesterol for accurate CYP3A phenotyping.

• Authors : Oda, Ayako¹ (AUTHOR); Suzuki, Yosuke¹ (AUTHOR) y‐suzuki@my‐pharm.ac.jp; Sato, Haruki¹ (AUTHOR)

• Source: CTS: Clinical & Translational Science. Mar2024, Vol. 17 Issue 3, p1-11. 11p.

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In vitro and in vivo metabolic activation and hepatotoxicity of chlorzoxazone mediated by CYP3A.

• Authors : Sun, Chen¹ (AUTHOR); Zhang, Mingyu¹ (AUTHOR); Guan, Chunjing¹ (AUTHOR)

Subjects: *BIOTRANSFORMATION (Metabolism); *CYTOCHROME P-450 CYP3A; *HEPATOTOXICOLOGY

• Source: Archives of Toxicology. Apr2024, Vol. 98 Issue 4, p1095-1110. 16p.

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Elucidating Contributions of Drug Transporters/Enzyme to Nonlinear Pharmacokinetics of Grazoprevir by PBPK Modeling With a Cluster Gauss–Newton Method.

• Authors : Yoshikado, Takashi¹ (AUTHOR) ; Aoki, Yasunori^2,3 (AUTHOR); Nakamura, Ryo¹ (AUTHOR)

• Source: CPT: Pharmacometrics & Systems Pharmacology. Apr2025, Vol. 14 Issue 4, p770-780. 11p.

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Study to Assess the Effect of a CYP3A Weak Inducer Rufinamide on Quizartinib Pharmacokinetics in Healthy Subjects

• Source: A Phase 1, Open Label, Randomized, Parallel Drug Interaction Study to Evaluate the Effect of a CYP3A Weak Inducer Rufinamide on the Pharmacokinetics of Quizartinib in

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