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RBM17 Promotes the Chemoresistance of Oral Squamous Cancer Cells Through Checkpoint Kinase 1.

• Authors : Nakahara, Miyuka¹ (AUTHOR); Arai, Ryosuke² (AUTHOR); Tokuoka, Isao^2,3 (AUTHOR)

Subjects: *Checkpoint kinase 1; *Head & neck cancer; *Ataxia telangiectasia mutated protein

• Source: International Journal of Molecular Sciences. Apr2025, Vol. 26 Issue 7, p3127. 14p.

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Checkpoint Kinase 1 Inhibitor Combined with Low Dose Hydroxyurea Promotes ATM-Activated NF-κB-Dependent Pro-Inflammatory Chemokine Expression in Melanomas.

• Authors : Goh, Nicole Lisa Li-Ann¹ (AUTHOR); Abdul Rahim, Nur Jannah^1,2 (AUTHOR); Bhatt, Rituparna¹ (AUTHOR)

• Source: Cancers. Jun2025, Vol. 17 Issue 11, p1817. 13p.

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Checkpoint kinase 1 inhibitor + low‐dose hydroxyurea efficiently kills BRAF inhibitor‐ and immune checkpoint inhibitor‐resistant melanomas.

• Authors : Zeng, Zhen¹ (AUTHOR); Ngo, Hung Long¹ (AUTHOR); Proctor, Martina¹ (AUTHOR)

• Source: Pigment Cell & Melanoma Research. Jan2024, Vol. 37 Issue 1, p45-50. 6p.

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A Novel Approach: Investigating the Intracellular Clearance Mechanism of Glyceraldehyde-Derived Advanced Glycation End-Products Using the Artificial Checkpoint Kinase 1 d270KD Mutant as a Substrate Model.

• Authors : Takeda, Kenji^1,2 (AUTHOR) ; Sakai-Sakasai, Akiko¹ (AUTHOR) ; Kajinami, Kouji² (AUTHOR)

• Source: Cells (2073-4409). Dec2023, Vol. 12 Issue 24, p2838. 26p.

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A Study of PEP07 (Checkpoint Kinase 1 Inhibitor) in Patients with Advanced or Metastatic Solid Tumors

• Source: A Phase I Study of PEP07 (Checkpoint Kinase 1 Inhibitor) in Patients with Advanced or Metastatic Solid

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Antitumor Activity of Radiation Therapy Combined with Checkpoint Kinase Inhibition in SHH/ p53 -Mutated Human Medulloblastoma.

• Authors : Kuchařová, Zuzana¹ (AUTHOR); Glasow, Annegret^1,2 (AUTHOR); Kortmann, Rolf-Dieter¹ (AUTHOR)

Subjects: *CHECKPOINT kinase 1; *DNA damage; *TUMOR growth

• Source: International Journal of Molecular Sciences. Mar2025, Vol. 26 Issue 6, p2577. 17p.

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Checkpoint Kinase 1 Stimulates Endogenous Cardiomyocyte Renewal and Cardiac Repair by Binding to Pyruvate Kinase Isoform M2 C‐Domain and Activating Cardiac Metabolic Reprogramming in a Porcine Model of Myocardial Ischemia/Reperfusion Injury

• Authors : Tian‐Wen Wei; Tian‐Kai Shan; Hao Wang

Subjects: Thyroid Hormones; Swine; Pyruvate Kinase

• Source: J Am Heart AssocJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 13 (2024)

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Predicting breast cancer prognosis based on a novel pathomics model through CHEK1 expression analysis using machine learning algorithms.

• Authors : Chen, Chen¹ (AUTHOR); Gao, Dan¹ (AUTHOR); Yue, Huan² (AUTHOR)

Subjects: *CHECKPOINT kinase 1; *FEATURE extraction; *BREAST cancer prognosis

• Source: PLoS ONE. 5/9/2025, Vol. 20 Issue 5, p1-24. 24p.

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BCCIP promotes resistance of gastric cancer to cisplatin by modulating DNA damage repair pathways.

• Authors : JIA Zhe¹; ZENG Guangyan¹; ZOU Peng^1,2

• Source: Chinese Journal of Pathophysiology. May2025, Vol. 41 Issue 5, p871-881. 11p.

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Small-Molecule Mitotic Inhibitors as Anticancer Agents: Discovery, Classification, Mechanisms of Action, and Clinical Trials.

• Authors : Salinas, Yazmin¹ (AUTHOR); Chauhan, Subhash C.^2,3 (AUTHOR); Bandyopadhyay, Debasish^1,3,4 (AUTHOR)

Subjects: *Microtubule-associated protein kinase; *Checkpoint kinase 1; *Antimitotic agents

• Source: International Journal of Molecular Sciences. Apr2025, Vol. 26 Issue 7, p3279. 36p.

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