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Bioequivalence of rimegepant, a small molecule CGRP receptor antagonist, administered as an oral tablet, a sublingual orally disintegrating tablet, and a supralingual orally disintegrating tablet: two phase 1 randomized studies in healthy adults.

• Authors : Croop, Robert¹ (AUTHOR); Bhardwaj, Rajinder² (AUTHOR); Anderson, Matt S.² (AUTHOR)

• Source: Cephalalgia. Feb2024, Vol. 44 Issue 2, p1-12. 12p.

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Efficient and Scalable Enantioselective Synthesis of a Key Intermediate for Rimegepant: An Oral CGRP Receptor Antagonist

• Authors : Zhonghua Luo; Guodong Sun; Guowei Wang

Subjects: rimegepant; enantioselective synthesis; Ru-catalyzed

• Source: Pharmaceutical Fronts, Vol 06, Iss 01, Pp e62-e68 (2024)

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Efficient and Scalable Enantioselective Synthesis of a Key Intermediate for Rimegepant: An Oral CGRP Receptor Antagonist

• Authors : Luo, Zhonghua; Sun, Guodong; Wang, Guowei

• Source: Pharmaceutical Fronts ; volume 06, issue 01, page e62-e68 ; ISSN 2628-5088 2628-5096

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CGRP receptor antagonist MK-8825 attenuates cortical spreading depression induced pain behavior

Subjects: CGRP; cortical spreading depression; Migraine

• Source: Filiz , A , Tepe , N , Eftekhari , S , Boran , H E , Dilekoz , E , Edvinsson , L & Bolay , H 2019 , ' CGRP receptor

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Solid‐Phase Thiol–Ene Lipidation of Peptides for the Synthesis of a Potent CGRP Receptor Antagonist.

• Authors : Williams, Elyse T.^1,2; Harris, Paul W. R.^1,2,3; Jamaluddin, Muhammad A.^2,3

• Source: Angewandte Chemie. 9/3/2018, Vol. 130 Issue 36, p11814-11817. 4p.

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The CGRP receptor antagonist BIBN4096 inhibits prolonged meningeal afferent activation evoked by brief local K+ stimulation but not cortical spreading depression-induced afferent sensitization

• Authors : Jun Zhao; Dan Levy

Subjects: Anesthesiology; RD78.3-87.3

• Source: PAIN Reports, Vol 3, Iss 1, p e632 (2018)

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Lack of hemodynamic interaction between CGRP-receptor antagonist telcagepant (MK-0974) and sumatriptan: Results from a randomized study in patients with migraine.

• Authors : Depré, M¹; MacLeod, C²; Palcza, J³

• Source: Cephalalgia. Dec2013, Vol. 33 Issue 16, p1292-1301. 10p.

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The novel CGRP receptor antagonist BIBN4096 BS alleviates a postoperative intestinal inflammation and prevents postoperative ileus.

• Authors : Glowka, T. R.¹; Steinebach, A.¹; Stein, K.¹

• Source: Neurogastroenterology & Motility. Jul2015, Vol. 27 Issue 7, p1038-1049. 12p.

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Randomized controlled trial of the CGRP receptor antagonist telcagepant for migraine prevention

Subjects: Adult; Alanine Transaminase; Aspartate Aminotransferases

• Source: Ho , T W , Connor , K M , Zhang , Y , Pearlman , E , Koppenhaver , J , Fan , X , Lines , C , Edvinsson , L , Goadsby , P J & Michelson , D 2014 , ' Randomized controlled trial of the

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Randomized controlled trial of the CGRP receptor antagonist telcagepant for migraine prevention

Subjects: Adult; Alanine Transaminase; Aspartate Aminotransferases

• Source: Ho , T W , Connor , K M , Zhang , Y , Pearlman , E , Koppenhaver , J , Fan , X , Lines , C , Edvinsson , L , Goadsby , P J & Michelson , D 2014 , ' Randomized controlled trial of the

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