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Figure 5. Effects of CB dysfunction on blood pressure regulation. ; (A–C) Circadian variations in baseline systolic blood pressure (A, continued line), diastolic blood pressure (A, broken line), mean blood pressure (B) and heart rate (C) of HIF-2αWT(black, n = 10) and TH-HIF-2αKO (red, n = 8) littermates recorded by radiotelemetry. White and black boxes depict diurnal and nocturnal periods, respectively. Data are presented as averaged values every hour ±SEM. Area under the curve followed by unpaired t-test are shown. BP, blood pressure. HR, heart rate in beats per minute. (D–F) Mean blood pressure (D), heart rate (E) and subcutaneous temperature (F) alteration in response to hypoxia in radiotelemetry-implanted TH-HIF-2αKO (red, n = 5) compared to HIF-2αWT(black, n = 5). Shift and duration of 10% O2 are indicated in the graph. White and black boxes represent diurnal and nocturnal periods, respectively. Data are presented as averaged values every hour ±SEM. Recovery across the hypoxia period was analysed by one-phase association curve fitting. BP, blood pressure. HR, heart rate in beats per minute. (G) Schematic representation of the protocol followed in the Ang II-induced experimental hypertension model. (H–M) Mean blood pressure and heart rate recorded from HIF-2αWT(black, n = 8) and TH-HIF-2αKO (red, n = 8) mice after 7 days (H and K), 14 days (I and L) and 21 days (J and M) of Ang II infusion. White and black boxes depict diurnal and nocturnal periods, respectively. Data are presented as averaged values every hour ±SEM. Area under the curve followed by unpaired t-test are shown. BP, blood pressure. HR, heart rate in beats per minute.

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Academic Journal

Changes in Emotional Vitality as a Predictor of Levels and Change in Allostatic Load:Longitudinal Results From the Whitehall II Cohort Study

Subjects: psychological well-being; emotional vitality; allostatic load

  • Source: Deen , L , Dich , N , Head , J & Clark , A J 2020 , ' Changes in Emotional Vitality as a Predictor of Levels and Change in Allostatic Load : Longitudinal Results From the Whitehall II Cohort Study ' ,

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