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Acetaminophen: Properties, Clinical Uses and Adverse Effects

• Authors : Latifpour, Pasha; Javaherian, Atash

Subjects: AcetaminophenMEDICAL / Pain Management

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Modeling and Simulation of Acetaminophen Pharmacokinetics and Hepatic Biomarkers After Overdoses of Extended‐Release and Immediate‐Release Formulations in Healthy Adults Using the Quantitative Systems Toxicology Software Platform DILIsym.

• Authors : Beaudoin, James J.¹ (AUTHOR) ; Yang, Kyunghee¹ (AUTHOR); Howell, Brett A.¹ (AUTHOR)

• Source: CPT: Pharmacometrics & Systems Pharmacology. Apr2025, Vol. 14 Issue 4, p681-694. 14p.

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Thermodynamics analysis of acetaminophen and its metabolites using density functional theory.

• Authors : Mekky, Abdel-baset H.¹

Subjects: *THERMODYNAMICS; *ACETAMINOPHEN; *METABOLITES

• Source: Umm Al-Qura University Journal of Applied Sciences (Springer Nature). Dec2024, Vol. 10 Issue 4, p603-612. 10p.

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A Study of an Acetaminophen/Naproxen Sodium Fixed Combination, Acetaminophen and Naproxen Sodium in Postoperative Dental Pain

• Source: A Full-Factorial, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Single-Dose Efficacy and Safety Study of an Acetaminophen/Naproxen Sodium Fixed

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Additive effect of a single intravenous dose of acetaminophen administered at the end of laparoscopic hysterectomy on postoperative pain control with nefopam and fentanyl-based patient-controlled analgesia: a double-blind, randomized controlled trial.

• Authors : Nam S; Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehak-Ro, Jongno-Gu, Seoul, 03080, Korea.; Yoo S

Subjects: Pain, Postoperative*/Pain, Postoperative*/Pain, Postoperative*/drug therapy ; Pain, Postoperative*/Pain, Postoperative*/Pain, Postoperative*/prevention & control ; Nefopam*/Nefopam*/Nefopam*/administration & dosage

• Source: BMC anesthesiology [BMC Anesthesiol] 2025 Feb 20; Vol. 25 (1), pp. 88. Date of Electronic Publication: 2025 Feb 20.Publisher: BioMed Central Country of Publication: England NLM ID: 100968535 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2253

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Underlying mechanisms and treatment of acetaminophen‑induced liver injury (Review).

• Authors : Li R; Chinese Medicine College, Hubei University of Chinese Medicine, Wuhan, Hubei 430065, P.R. China.; Wu H

Subjects: Acetaminophen*/Acetaminophen*/Acetaminophen*/adverse effects ; Chemical and Drug Induced Liver Injury*/Chemical and Drug Induced Liver Injury*/Chemical and Drug Induced Liver Injury*/etiology ; Liver*/Liver*/Liver*/metabolism

• Source: Molecular medicine reports [Mol Med Rep] 2025 Apr; Vol. 31 (4). Date of Electronic Publication: 2025 Feb 28.Publisher: D. A. Spandidos Country of Publication: Greece NLM ID: 101475259 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Forsythiaside A Reduces Acetaminophen Hepatotoxic Metabolism by Inhibiting Pregnane X Receptor.

• Authors : Pu S; College of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China.; Pan Y

Subjects: Pregnane X Receptor*/Pregnane X Receptor*/Pregnane X Receptor*/metabolism ; Acetaminophen*/Acetaminophen*/Acetaminophen*/adverse effects ; Oxidative Stress*/Oxidative Stress*/Oxidative Stress*/drug effects

• Source: Molecules (Basel, Switzerland) [Molecules] 2025 Mar 06; Vol. 30 (5). Date of Electronic Publication: 2025 Mar 06.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Dihydromyricetin Alleviated Acetaminophen-Induced Acute Kidney Injury via Nrf2-Dependent Anti-Oxidative and Anti-Inflammatory Effects.

• Authors : Shi J; Department of Pharmacology, School of Pharmacy, Nantong University, Nantong 226019, China.; Peng X

Subjects: NF-E2-Related Factor 2*/NF-E2-Related Factor 2*/NF-E2-Related Factor 2*/metabolism ; Acute Kidney Injury*/Acute Kidney Injury*/Acute Kidney Injury*/drug therapy ; Acute Kidney Injury*/Acute Kidney Injury*/Acute Kidney Injury*/metabolism

• Source: International journal of molecular sciences [Int J Mol Sci] 2025 Mar 06; Vol. 26 (5). Date of Electronic Publication: 2025 Mar 06.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Efficacy of scheduled intravenous acetaminophen administration for catheter-related bladder discomfort in patients after transurethral resection of bladder tumors: A prospective randomized pilot study.

• Authors : Hatayama T; Department of Urology, Hiroshima City North Medical Center Asa Citizens Hospital, Hiroshima, Japan.; Department of Urology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan.

Subjects: Acetaminophen*/Acetaminophen*/Acetaminophen*/administration & dosage ; Acetaminophen*/Acetaminophen*/Acetaminophen*/therapeutic use ; Urinary Bladder Neoplasms*/Urinary Bladder Neoplasms*/Urinary Bladder Neoplasms*/surgery

• Source: Investigative and clinical urology [Investig Clin Urol] 2025 Mar; Vol. 66 (2), pp. 144-151.Publisher: Korean Urological Association Country of Publication: Korea (South) NLM ID: 101674989 Publication Model: Print Cited Medium: Internet

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TREOCAPA: prophylactic treatment of the ductus arteriosus in preterm infants by acetaminophen-statistical analysis plan for the randomized phase III group sequential trial.

• Authors : Ursino M; TREOCAPA study group

Subjects: Acetaminophen*/Acetaminophen*/Acetaminophen*/therapeutic use ; Acetaminophen*/Acetaminophen*/Acetaminophen*/adverse effects ; Ductus Arteriosus, Patent*/Ductus Arteriosus, Patent*/Ductus Arteriosus, Patent*/drug therapy

• Source: Trials [Trials] 2025 Feb 13; Vol. 26 (1), pp. 52. Date of Electronic Publication: 2025 Feb 13.Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215

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