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Biospecimen Biorepository for the Study of ALS, ALS-FTD and Similar Neurodegenerative Disorders

• Authors : National Institute of Neurological Disorders and Stroke (NINDS); Bjorn E. Oskarsson, Principal Investigator

• Source: Biospecimen Biorepository for the Study of ALS, ALS-FTD and Similar Neurodegenerative Disorders

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Direct and Indirect Protein Interactions Link FUS Aggregation to Histone Post-Translational Modification Dysregulation and Growth Suppression in an ALS/FTD Yeast Model.

• Authors : Bennett, Seth A.^1,2 (AUTHOR); Cobos, Samantha N.^1,3 (AUTHOR); Fisher, Raven M. A.^1,2 (AUTHOR)

• Source: Journal of Fungi. Jan2025, Vol. 11 Issue 1, p58. 22p.

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Genetics and Environment INtersection in the ALS-FTD Spectrum: an Italian Twins Cohort StudY with a Multi-Omics Approach (GENIALITY)

• Authors : A.O.U. Città della Salute e della Scienza - Molinette Hospital; Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo; University of Modena and Reggio Emilia ...

• Source: Genetics and Environment INtersection in the Amyotrophic Lateral Sclerosis - FrontoTemporal Dementia Spectrum: an Italian Twins Cohort StudY with a Multi-Omics Approach

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Safety and Therapeutic Potential of the FDA-approved Drug Metformin for C9orf72 ALS/FTD

• Authors : ALS Association

• Source: A Single-Center, Open Label Study to Assess the Safety and Tolerability of Metformin in Subjects With C9orf72 Amyotrophic Lateral Sclerosis Over 24 Weeks of TreatmentCedarbaum JM, Stambler N,

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A high-fidelity CRISPR-Cas13 system improves abnormalities associated with C9ORF72-linked ALS/FTD

• Authors : Tristan X. McCallister; Colin K. W. Lim; Mayuri Singh

Subjects: Science

• Source: Nature Communications, Vol 16, Iss 1, Pp 1-17 (2025)

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Dual-targeting CRISPR-CasRx reduces C9orf72 ALS/FTD sense and antisense repeat RNAs in vitro and in vivo

• Authors : Liam Kempthorne; Deniz Vaizoglu; Alexander J. Cammack

Subjects: Science

• Source: Nature Communications, Vol 16, Iss 1, Pp 1-15 (2025)

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Human VCP mutant ALS/FTD microglia display immune and lysosomal phenotypes independently of GPNMB.

• Authors : Clarke, Benjamin E.^1,2 (AUTHOR) ; Ziff, Oliver J.^1,2,3 (AUTHOR) ; Tyzack, Giulia^1,2 (AUTHOR)

• Source: Molecular Neurodegeneration. 11/26/2024, Vol. 19 Issue 1, p1-24. 24p.

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Molecular Mechanisms of Phase Separation and Amyloidosis of ALS/FTD-linked FUS and TDP-43.

• Authors : Jianxing Song¹

• Source: Aging & Disease. Oct2024, Vol. 15 Issue 5, p2084-2112. 29p.

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Targeting the TDP-43 low complexity domain blocks spreading of pathology in a mouse model of ALS/FTD.

• Authors : Chevalier, Elodie¹ (AUTHOR); Audrain, Mickael¹ (AUTHOR); Ratnam, Monisha¹ (AUTHOR)

• Source: Acta Neuropathologica Communications. 10/3/2024, Vol. 12 Issue 1, p1-14. 14p.

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A pathogenic mutation in the ALS/FTD gene VCP induces mitochondrial hypermetabolism by modulating the permeability transition pore

• Authors : Silke Vanderhaeghe; Jovan Prerad; Arun Kumar Tharkeshwar

Subjects: Amyotrophic lateral sclerosis; Frontotemporal dementia; VCP

• Source: Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-16 (2024)

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