نتائج البحث

Rapamycin: Effectiveness, Safety and Drug Interactions

• Authors : Martin J. Blanco

Subjects: RapamycinMEDICAL / Pharmacology

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The ion channel TRPM8 is a direct target of the immunosuppressant rapamycin in primary sensory neurons

• Authors : Arcas, JM; Oudaha, K; Gonzalez, A

Subjects: Medicin och hälsovetenskap

• Source: British journal of pharmacology. 181(17):3192-3214

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Integrating rapamycin with novel PI3K/Akt/mTOR inhibitor microRNAs on NOTCH1-driven T-cell acute lymphoblastic leukemia (T-ALL).

• Authors : Arjmand, Fateme¹; Shojaei, Samaneh²; Khalili, Mitra^1,3

• Source: BioImpacts. Jul2024, Vol. 14 Issue 4, p1-12. 12p.

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Reprogramming Macrophage Polarization, Depleting ROS by Astaxanthin and Thioketal‐Containing Polymers Delivering Rapamycin for Osteoarthritis Treatment.

• Authors : Li, Huiyun¹ (AUTHOR); Yuan, Yusong² (AUTHOR); Zhang, Lingpu³ (AUTHOR)

• Source: Advanced Science. 3/6/2024, Vol. 11 Issue 9, p1-19. 19p.

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Role of maraviroc and/or rapamycin in the liver of IL10 KO mice with frailty syndrome.

• Authors : Pérez-Martínez, Laura¹ (AUTHOR) ; Romero, Lourdes¹ (AUTHOR); Verdugo-Sivianes, Eva M.^2,3 (AUTHOR)

Subjects: *FRAILTY; *RAPAMYCIN; *CELLULAR aging

• Source: PLoS ONE. 1/10/2024, Vol. 19 Issue 1, p1-14. 14p.

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Integrated bioinformatics analysis and experimental validation identified CDCA families as prognostic biomarkers and sensitive indicators for rapamycin treatment of glioma.

• Authors : Li, Ren^1,2 (AUTHOR); Chen, Yang¹ (AUTHOR); Yang, Biao¹ (AUTHOR)

Subjects: *BIOINFORMATICS; *PROGNOSIS; *GLIOMAS

• Source: PLoS ONE. 1/5/2024, Vol. 19 Issue 1, p1-24. 24p.

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Unraveling the Role of Ras Homolog Enriched in Brain (Rheb1 and Rheb2): Bridging Neuronal Dynamics and Cancer Pathogenesis through Mechanistic Target of Rapamycin Signaling.

• Authors : Rahman, Mostafizur¹ (AUTHOR) ; Nguyen, Tuan Minh¹ (AUTHOR) ; Lee, Gi Jeong¹ (AUTHOR)

Subjects: *CARCINOGENESIS; *RAPAMYCIN; *CELL proliferation

• Source: International Journal of Molecular Sciences. Feb2024, Vol. 25 Issue 3, p1489. 30p.

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CAR Gene Delivery by T‐cell Targeted Lentiviral Vectors is Enhanced by Rapamycin Induced Reduction of Antiviral Mechanisms.

• Authors : Charitidis, Filippos T¹ (AUTHOR); Adabi, Elham¹ (AUTHOR); Ho, Naphang¹ (AUTHOR)

• Source: Advanced Science. Dec2023, Vol. 10 Issue 35, p1-14. 14p.

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Exploring the translational potential of PLGA nanoparticles for intra-articular rapamycin delivery in osteoarthritis therapy.

• Authors : Ma, Jian-Chao¹ (AUTHOR); Luo, Tingting¹ (AUTHOR); Feng, Binyang¹ (AUTHOR)

• Source: Journal of Nanobiotechnology. 10/4/2023, Vol. 21 Issue 1, p1-18. 18p.

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Formulation of cost-effective medium and optimization studies for enhanced production of rapamycin.

• Authors : K. Ganesh, Sanjeev.¹ (AUTHOR); C, Subathra Devi¹ (AUTHOR)

Subjects: *RAPAMYCIN; *SUSTAINABILITY; *MEDIA studies

• Source: Microbial Cell Factories. 9/20/2023, Vol. 22 Issue 1, p1-12. 12p.

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Effects of Early Exposure to Isoflurane on Susceptibility to Chronic Pain Are Mediated by Increased Neural Activity Due to Actions of the Mammalian Target of the Rapamycin Pathway.

• Authors : Li, Qun¹ (AUTHOR) ; Mathena, Reilley Paige¹ (AUTHOR) ; Li, Fengying¹ (AUTHOR)

Subjects: *PURINERGIC receptors; *GLIAL fibrillary acidic protein; *CHRONIC pain

• Source: International Journal of Molecular Sciences. Sep2023, Vol. 24 Issue 18, p13760. 21p.

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Structural Insights into the Giardia lamblia Target of Rapamycin Homolog: A Bioinformatics Approach.

• Authors : Muñoz-Muñoz, Patricia L. A.¹ (AUTHOR) ; Mares-Alejandre, Rosa E.¹ (AUTHOR) ; Meléndez-López, Samuel G.¹ (AUTHOR)

Subjects: *GIARDIA lamblia; *TOR proteins; *DRUG design

• Source: International Journal of Molecular Sciences. Aug2023, Vol. 24 Issue 15, p11992. 12p.

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The Case for the Target of Rapamycin Pathway as a Candidate Circadian Oscillator.

• Authors : Lakin-Thomas, Patricia¹ (AUTHOR)

Subjects: *RAPAMYCIN; *CIRCADIAN rhythms; *CELLULAR signal transduction

• Source: International Journal of Molecular Sciences. Sep2023, Vol. 24 Issue 17, p13307. 17p.

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Nuclear receptor subfamily 1 group D member 1 suppresses the proliferation, migration of adventitial fibroblasts, and vascular intimal hyperplasia via mammalian target of rapamycin complex 1/β-catenin pathway.

• Authors : Ke Peng^1,2; Mingliang Wang²; Jun Wang³

• Source: Clinical & Experimental Hypertension. Dec2023, Vol. 45 Issue 1, p1-10. 10p.

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Rapamycin downregulates α-klotho in the kidneys of female rats with normal and reduced renal function.

• Authors : Espartero, Azahara^1,2 (AUTHOR); Vidal, Angela^1,2 (AUTHOR); Lopez, Ignacio^1,2 (AUTHOR)

Subjects: *KIDNEY physiology; *RAPAMYCIN; *RATS

• Source: PLoS ONE. 11/28/2023, Vol. 18 Issue 11, p1-15. 15p.

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Genome instability footprint under rapamycin and hydroxyurea treatments.

• Authors : Li, Jing^1,2 (AUTHOR); Stenberg, Simon³ (AUTHOR); Yue, Jia-Xing^1,2 (AUTHOR)

• Source: PLoS Genetics. 11/06/2023, Vol. 19 Issue 11, p1-23. 23p.

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Translatome analysis of tuberous sclerosis complex 1 patient-derived neural progenitor cells reveals rapamycin-dependent and independent alterations.

• Authors : Aksoylu, Inci S.¹ (AUTHOR); Martin, Pauline² (AUTHOR); Robert, Francis³ (AUTHOR)

• Source: Molecular Autism. 10/25/2023, Vol. 14 Issue 1, p1-20. 20p.

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Astragalus polysaccharide restores insulin secretion impaired by lipopolysaccharides through the protein kinase B /mammalian target of rapamycin/glucose transporter 2 pathway.

• Authors : Ren, Xiaodan^1,2 (AUTHOR); Dai, Ying² (AUTHOR); Shan, Mengya² (AUTHOR)

Subjects: *POLYSACCHARIDES; *LIPOPOLYSACCHARIDES; *PROTEIN kinases

• Source: BMC Complementary Medicine & Therapies. 10/10/2023, Vol. 23 Issue 1, p1-10. 10p. 8 Graphs.

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Increased Expression of α-Hemoglobin Stabilizing Protein (AHSP) mRNA in Erythroid Precursor Cells Isolated from β-Thalassemia Patients Treated with Sirolimus (Rapamycin).

• Authors : Zurlo, Matteo¹ (AUTHOR) ; Zuccato, Cristina^1,2 (AUTHOR) ; Cosenza, Lucia Carmela¹ (AUTHOR)

• Source: Journal of Clinical Medicine. May2024, Vol. 13 Issue 9, p2479. 13p.

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A New Hypothesis Describing the Pathogenesis of Oral Mucosal Injury Associated with the Mammalian Target of Rapamycin (mTOR) Inhibitors.

• Authors : Sonis, Stephen; Villa, Alessandro

Subjects: aphthous; cancer; everolimus

• Source: Cancers. 16(1)

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Targeted Rapamycin Delivery via Magnetic Nanoparticles to Address Stenosis in a 3D Bioprinted in Vitro Model of Pulmonary Veins.

• Authors : Ning, Liqun^1,2 (AUTHOR); Zanella, Stefano¹ (AUTHOR); Tomov, Martin L.¹ (AUTHOR)

• Source: Advanced Science. 7/10/2024, Vol. 11 Issue 26, p1-19. 19p.

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Sex, tissue, and mitochondrial interactions modify the transcriptional response to rapamycin in Drosophila

• Authors : Yevgeniy Raynes; John C. Santiago; Faye A. Lemieux

Subjects: mTOR; Rapamycin; Mitonuclear genotype

• Source: BMC Genomics, Vol 25, Iss 1, Pp 1-17 (2024)

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Metabolic Effects on Mouse Embryonic Stem Cells and the Canonical Mammalian Target of Rapamycin Pathway.

• Authors : Correia, Bibiana^1,2 ; Sousa, Maria Inês^1,2 ; Ramalho-Santos, João^1,2

• Source: BioChem. Dec2023, Vol. 3 Issue 4, p170-181. 12p.

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Exploring the Impacts of Mucin 1 Gene Expression on Apoptosis and Autophagy in Thyroid Cancer Cells via Adenosine-Monophosphate Activated-Protein Kinase-Mammalian Target of Rapamycin Signaling Pathway.

• Authors : LIMIN WEI¹; WEI CHENG²

• Source: Indian Journal of Pharmaceutical Sciences. May/Jun2024, Vol. 86 Issue 3, p932-939. 8p.

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Clinical and dermoscopic improvement of angiokeratoma in a child with topical rapamycin.

• Authors : Farajzadeh, Saeedeh (AUTHOR); Pardakhty, Abbas¹ (AUTHOR); Afshar, Kimia² (AUTHOR)

• Source: Indian Journal of Dermatology, Venereology & Leprology. Jan/Feb2024, Vol. 90 Issue 1, p1-3. 3p.

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Single-Dose Treatment with Rapamycin Preserves Post-Ischemic Cardiac Function through Attenuation of Fibrosis and Inflammation in Diabetic Rabbit.

• Authors : Samidurai, Arun¹ (AUTHOR) ; Saravanan, Manu¹ (AUTHOR); Ockaili, Ramzi¹ (AUTHOR)

Subjects: *RAPAMYCIN; *FIBROSIS; *MYOCARDIAL ischemia

• Source: International Journal of Molecular Sciences. May2023, Vol. 24 Issue 10, p8998. 17p.

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Rapamycin Perfluorocarbon Nanoparticle Mitigates Cisplatin-Induced Acute Kidney Injury.

• Authors : Zhou, Qingyu¹ (AUTHOR); Quirk, James D.² (AUTHOR); Hu, Ying³ (AUTHOR)

Subjects: *RAPAMYCIN; *CISPLATIN; *ACUTE kidney failure

• Source: International Journal of Molecular Sciences. Apr2023, Vol. 24 Issue 7, p6086. 17p.

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Exosomes are involved in the intercellular transfer of rapamycin resistance in the breast cancer cells.

• Authors : Shchegolev, Yuri Yu.¹; Sorokin, Danila V.¹; Scherbakov, Alexander M.¹

• Source: BioImpacts. Jul2023, Vol. 13 Issue 4, p313-321. 9p.

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MAPK13 stabilization via m6A mRNA modification limits anticancer efficacy of rapamycin

• Authors : Kim, Joohwan; Chun, Yujin; Ramirez, Cuauhtemoc B

Subjects: Biochemistry and Cell Biology; Biomedical and Clinical Sciences; Oncology and Carcinogenesis

• Source: Journal of Biological Chemistry. 299(9)

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Contractile and Genetic Characterization of Cardiac Constructs Engineered from Human Induced Pluripotent Stem Cells: Modeling of Tuberous Sclerosis Complex and the Effects of Rapamycin.

• Authors : Sidorov, Veniamin Y.^1,2 (AUTHOR) ; Sidorova, Tatiana N.³ (AUTHOR); Samson, Philip C.^1,4 (AUTHOR)

• Source: Bioengineering (Basel). Mar2024, Vol. 11 Issue 3, p234. 24p.

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Rapamycin improves social and stereotypic behavior abnormalities induced by pre‐mitotic neuronal subset specific Pten deletion.

• Authors : Narvaiz, David A.¹ (AUTHOR); Nolan, Suzanne O.¹ (AUTHOR); Smith, Gregory D.² (AUTHOR)

• Source: Genes, Brain & Behavior. Aug2023, Vol. 22 Issue 4, p1-12. 12p.

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Effect of Rapamycin in Ovarian Aging (Rapamycin)

• Authors : Samuel Zev Williams, Associate Professor of Obstetrics and Gynecology

• Source: Effect of Rapamycin in Ovarian Aging

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Therapeutic Effect of Rapamycin on TDP-43-Related Pathogenesis in Ischemic Stroke.

• Authors : Tsou, Yi-Syue^1,2,3 (AUTHOR); Lai, Jing-Huei^4,5 (AUTHOR); Chen, Kai-Yun¹ (AUTHOR)

Subjects: *ISCHEMIC stroke; *RAPAMYCIN; *ALZHEIMER'S disease

• Source: International Journal of Molecular Sciences. Jan2023, Vol. 24 Issue 1, p676. 18p.

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Evaluating the effect of rapamycin treatment in Alzheimer’s disease and aging using in vivo imaging: the ERAP phase IIa clinical study protocol

• Authors : Jonas E. Svensson; Martin Bolin; Daniel Thor

Subjects: Rapamycin; Sirolimus; Alzheimer’s disease

• Source: BMC Neurology, Vol 24, Iss 1, Pp 1-10 (2024)

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Discrete Mechanistic Target of Rapamycin Signaling Pathways, Stem Cells, and Therapeutic Targets.

• Authors : Jhanwar-Uniyal, Meena¹ (AUTHOR) ; Zeller, Sabrina L.¹ (AUTHOR); Spirollari, Eris¹ (AUTHOR)

• Source: Cells (2073-4409). Mar2024, Vol. 13 Issue 5, p409. 16p.

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Long-Term Outcome after Early Mammalian Target of Rapamycin Inhibitor-Based Immunosuppression in Kidney Transplant Recipients.

• Authors : Liefeldt, Lutz¹ (AUTHOR) ; Waiser, Johannes¹ (AUTHOR) ; Bachmann, Friederike¹ (AUTHOR)

• Source: Journal of Clinical Medicine. Aug2024, Vol. 13 Issue 15, p4305. 22p.

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Rapamycin-encapsulated nanoparticle delivery in polycystic kidney disease mice.

• Authors : Yamaguchi, Shinobu¹ (AUTHOR); Sedaka, Randee¹ (AUTHOR); Kapadia, Chintan² (AUTHOR)

• Source: Scientific Reports. 7/2/2024, Vol. 14 Issue 1, p1-8. 8p.

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Calorie restriction and rapamycin distinctly mitigate aging-associated protein phosphorylation changes in mouse muscles.

• Authors : Ataman M; Biozentrum, University of Basel, Basel, Switzerland. .; Swiss Institute of Bioinformatics, Basel, Switzerland. .

Subjects: Caloric Restriction* ; Aging*/Aging*/Aging*/metabolism ; Sirolimus*/Sirolimus*/Sirolimus*/pharmacology

• Source: Communications biology [Commun Biol] 2024 Aug 10; Vol. 7 (1), pp. 974. Date of Electronic Publication: 2024 Aug 10.Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN:

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Evaluation of Serum Pyruvate Kinase M2 and Key Glycolytic Signatures and Its Correlation with Phosphatidylinositol-3-kinase/Akt/Mammalian Target of Rapamycin Pathway in Women with Breast Carcinoma

• Authors : Flama Monteiro; Vijith Vittal Shetty; Shilpa S. Shetty

Subjects: breast cancer; hexokinase 2; lactate dehydrogenase a

• Source: Biomedical and Biotechnology Research Journal, Vol 8, Iss 2, Pp 154-159 (2024)

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Rapamycin in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

• Authors : Center For Complex Diseases-Seattle, WA; Sierra Internal Medicine, Incline Village, NV; Center for Complex Diseases- Palo Alto, CA

• Source: Gottschalk G, Peterson D, Knox K, Maynard M, Whelan RJ, Roy A. Elevated ATG13 in serum of patients with ME/CFS stimulates oxidative stress response in microglial cells via activation of receptor for

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The study of rapamycin nanofibrous membrane for preventing arteriovenous fistula stenosis

• Authors : Dan Rong; Taoxia Wang; Xiaoli Liu

Subjects: Chronic kidney disease; Hemodialysis; Arteriovenous fistula

• Source: Materials & Design, Vol 245, Iss , Pp 113297- (2024)

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Case Report: A case of rapamycin-eluting stent for the treatment of refractory stenosis of arteriovenous fistula stenosis

• Authors : Yu Xiong; Bo Tu; Minglu Zhang

Subjects: arteriovenous fistula; refractory stenosis; rapamycin-eluting stent

• Source: Frontiers in Cardiovascular Medicine, Vol 11 (2024)

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Targeting a mTOR/autophagy axis: a double-edged sword of rapamycin in spontaneous miscarriage

• Authors : Meng-Ying Li; Hui-Hui Shen; Xiao-Yan Cao

Subjects: Rapamycin; Autophagy; MTOR

• Source: Biomedicine & Pharmacotherapy, Vol 177, Iss , Pp 116976- (2024)

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Rapamycin-sensitive mechanisms confine the growth of fission yeast below the temperatures detrimental to cell physiology

• Authors : Morozumi, Yuichi; Mahayot, Fontip; Nakase, Yukiko

Subjects: Biochemistry and Cell Biology; Biological Sciences; Generic health relevance

• Source: iScience. 27(1)

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Evaluating the effect of rapamycin treatment in Alzheimer's disease and aging using in vivo imaging: the ERAP phase IIa clinical study protocol

• Authors : Svensson, JE; Bolin, M; Thor, D

Subjects: Medicin och hälsovetenskap

• Source: BMC neurology. 24(1):111

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Supplementation of rapamycin during in vitro maturation promotes oocyte quality and subsequent embryo development in bovine.

• Authors : Khatun, Hafiza^1,2 (AUTHOR) ; Islam, Md Rasadul² (AUTHOR); Khan, Muckta¹ (AUTHOR)

• Source: Bulletin of the National Research Centre. 6/29/2023, Vol. 47 Issue 1, p1-7. 7p.

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Rapamycin Alleviates Protein Aggregates, Reduces Neuroinflammation, and Rescues Demyelination in Globoid Cell Leukodystrophy.

• Authors : Lin, Dar-Shong^1,2 (AUTHOR) ; Huang, Yu-Wen³ (AUTHOR); Lee, Tsung-Han³ (AUTHOR)

• Source: Cells (2073-4409). Apr2023, Vol. 12 Issue 7, p993. 21p.

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Rapamycin vs TORin-1 or Gleevec vs Nilotinib: Simple chemical evolution that converts PAK1-blockers to TOR-blockers or vice versa?

• Authors : Hiroshi Maruta¹ ; Hong He²

• Source: Drug Discoveries & Therapeutics. Apr2024, Vol. 18 Issue 2, p134-139. 6p.

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Targeted co-delivery of rapamycin and oxaliplatin by liposomes suppresses tumor growth and metastasis of colorectal cancer

• Authors : Hang Yu; Shengyao Liu; Zhongwen Yuan

Subjects: Rapamycin; Oxaliplatin; Codelivery

• Source: Biomedicine & Pharmacotherapy, Vol 178, Iss , Pp 117192- (2024)

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Rapamycin circumvents anti PD-1 therapy resistance in colorectal cancer by reducing PD-L1 expression and optimizing the tumor microenvironment

• Authors : Menglei Jia; Zhongwen Yuan; Hang Yu

Subjects: PD-1/PD-L1; Colorectal cancer; Tumor microenvironment

• Source: Biomedicine & Pharmacotherapy, Vol 176, Iss , Pp 116883- (2024)

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