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Hydroxychloroquine-Induced Renal Phospholipidosis: Case Report and Review of Differential Diagnoses

• Authors : Amélie Friederike Menke; Barbara Heitplatz; Veerle Van Marck

Subjects: renal phospholipidosis; hydroxychloroquine; fabry disease

• Source: Case Reports in Nephrology and Dialysis, Vol 14, Iss 1, Pp 20-29 (2024)

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The role of lysosomal phospholipase A2 in the catabolism of bis(monoacylglycerol)phosphate and association with phospholipidosis

• Authors : Akira Abe; Vania Hinkovska-Galcheva; Philip Bouchev

Subjects: amiodarone; bis(monoacylglycerol)phosphate; cationic amphiphilic drug

• Source: Journal of Lipid Research, Vol 65, Iss 7, Pp 100574- (2024)

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Hydroxychloroquine-Induced Phospholipidosis - A Forgotten Complication of a Common Drug.

• Authors : Kothapalli, Nagamounika¹; Padiyar, Shivraj¹; Nair, Aswin M.²

• Source: Indian Journal of Nephrology. Mar/Apr2024, Vol. 34 Issue 2, p175-177. 3p.

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Double Hit of Hydroxichloroquine and Amiodarone Induced Renal Phospholipidosis in a Patient with Monoclonal Gammopathy and Sclerodermiform Syndrome: A Case Report and Review of the Literature

• Authors : José C. De la Flor; Pablo Rodríguez-Doyágüez; Daniel Villa

Subjects: drug-induced-phospholipidosis; zebra bodies; monoclonal gammopathy of renal significance

• Source: Medical Sciences, Vol 12, Iss 2, p 25 (2024)

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Hydroxychloroquine-Induced Renal Phospholipidosis: Case Report and Review of Differential Diagnoses.

• Authors : Menke, Amélie Friederike¹ (AUTHOR); Heitplatz, Barbara² (AUTHOR); Van Marck, Veerle² (AUTHOR)

• Source: Case Reports in Nephrology & Dialysis. Jan-Dec2024, Vol. 14 Issue 1, p20-29. 10p.

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Drug-induced phospholipidosis – causes, effects, identification

• Authors : Agnieszka Katarzyna Gonet-Surówka; Patrycja Dynarowicz-Łątka; Mariola Ciechacka

Subjects: phospholipidosis; cationic amphiphilic drugs; lamellar bodies

• Source: Farmacja Polska, Vol 78, Iss 11, Pp 628-634 (2023)

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Drug-induced phospholipidosis is not correlated with the inhibition of SARS-CoV-2 - inhibition of SARS-CoV-2 is cell line-specific

• Authors : Viktoria Diesendorf; Valeria Roll; Nina Geiger

Subjects: SARS-CoV-2; phospholipidosis; Vero E6

• Source: Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)

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Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2

• Authors : Tummino, Tia A; Rezelj, Veronica V; Fischer, Benoit

Subjects: Medicinal and Biomolecular Chemistry; Chemical Sciences; Infectious Diseases

• Source: Science. 373(6554)

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A machine learning and live-cell imaging tool kit uncovers small molecules induced phospholipidosis

• Authors : Hu, Huabin; Tjaden, Amelie; Knapp, Stefan

Subjects: Bioinformatics (Computational Biology); Bioinformatik (beräkningsbiologi); Article in journal

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Fosfolipidoza indukowana lekami – przyczyny, skutki, identyfikacja.

• Authors : Gonet-Surówka, Agnieszka Katarzyna¹ ; Dynarowicz-Łątka, Patrycja¹; Ciechacka, Mariola¹

• Source: Farmacja Polska. 2022, Vol. 78 Issue 11, p628-637. 10p.

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Inhibition of lysosomal phospholipase A2 predicts drug-induced phospholipidosis

• Authors : Vania Hinkovska-Galcheva; Taylour Treadwell; Jonathan M. Shillingford

Subjects: Acyltransferase; 1-O-acylceramide; lysosome

• Source: Journal of Lipid Research, Vol 62, Iss , Pp 100089- (2021)

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Investigating the role of endogenous opioid system in chloroquine‐induced phospholipidosis in rat liver by morphological, biochemical and molecular modelling studies.

• Authors : Malek, Mohammad Reza¹ (AUTHOR); Ahmadian, Shahin¹ (AUTHOR) ; Dehpour, Ahmad Reza² (AUTHOR)

• Source: Clinical & Experimental Pharmacology & Physiology. Sep2020, Vol. 47 Issue 9, p1575-1583. 9p. 2 Diagrams, 2 Charts, 3 Graphs.

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Attenuation of amiodarone induced lung fibrosis and phospholipidosis in hamsters, by treatment with the platelet activating factor receptor antagonist, WEB 2086.

• Authors : Giri, SN; Hyde, DM; Haynam, DR

Subjects: AMIODARONE; COLLAGEN; LIPID PEROXIDATION

• Source: Mediators of inflammation. 2(4)

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Biomarker discovery for drug-induced phospholipidosis: phenylacetylglycine to hippuric acid ratio in urine and plasma as potential markers.

• Authors : Kamiguchi, Hidenori¹ (AUTHOR) ; Murabayashi, Mika² (AUTHOR); Mori, Ikuo¹ (AUTHOR)

• Source: Biomarkers. Mar2017, Vol. 22 Issue 2, p178-188. 11p.

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Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2

• Authors : Veronica V. Rezelj; Audrey Fischer; Francesca Moretti ...

Subjects: Drug; General Science & Technology; media_common.quotation_subject

• Source: Science (New York, N.Y.)Science (New York, N.Y.), vol 373, iss 6554ScienceScience, 2021, 373 (6554), pp.541-547. ⟨10.1126/science.abi4708⟩

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Synthesis of di‐docosahexaenoyl (C22:6)‐bis(monoacylglycerol) phosphate in unlabelled and C‐13 labelled forms for use as a biomarker of drug induced phospholipidosis.

• Authors : Hickey, Michael J.¹ (AUTHOR); Lindqvist, Johnny² (AUTHOR); Ha, Young‐ Hwan³ (AUTHOR)

• Source: Journal of Labelled Compounds & Radiopharmaceuticals. Sep2019, Vol. 62 Issue 11, p695-706. 12p.

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Comparison of Oral, Intranasal and Aerosol Administration of Amiodarone in Rats as a Model of Pulmonary Phospholipidosis

• Authors : Aateka Patel; Ewelina Hoffman; Doug Ball

Subjects: phospholipidosis; amiodarone; foamy alveolar macrophages

• Source: Pharmaceutics, Vol 11, Iss 7, p 345 (2019)

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Why are most phospholipidosis inducers also hERG blockers?

• Authors : Slavov, Svetoslav¹; Stoyanova-Slavova, Iva¹; Li, Shuaizhang²

Subjects: *PARTIAL least squares regression; *PROTECTIVE groups (Chemistry); *CENTROID

• Source: Archives of Toxicology. Dec2017, Vol. 91 Issue 12, p3885-3895. 11p.

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Potentiation of Drug-Induced Phospholipidosis In Vitro through PEGlyated Graphene Oxide as the Nanocarrier.

• Authors : Liecheng Yang^1,2,3; Xiaoyan Zhong^1,2; Qian Li^1,3

Subjects: *LYSOSOMAL storage diseases; *DRUG side effects; *BIOACCUMULATION

• Source: Toxicological Sciences. Mar2017, Vol. 156 Issue 1, p39-53. 15p. 1 Color Photograph, 1 Diagram, 6 Graphs.

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AMALPHI: A Machine Learning Platform for Predicting Drug-Induced PhospholIpidosis

• Authors : Maria Cristina Lomuscio; Carmen Abate; Domenico Alberga

Subjects: Biochemistry; Medicine; Pharmacology

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Supplementary Material for: Hydroxychloroquine-Induced Renal Phospholipidosis: Case Report and Review of Differential Diagnoses

• Authors : Menke A.F.; Heitplatz B.; VanMarck V.

Subjects: Medicine; Renal phospholipidosis; Hydroxychloroquine

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Zebra-like bodies in COVID-19: is phospholipidosis evidence of hydroxychloroquine induced acute kidney injury?

• Authors : Obeidat, Mohammad¹ (AUTHOR); Isaacson, Alexandra L¹ (AUTHOR); Chen, Stephanie J.¹ (AUTHOR)

• Source: Ultrastructural Pathology. 2020, Vol. 44 Issue 4-6, p519-523. 5p.

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Investigating the role of endogenous opioid system in chloroquine‐induced phospholipidosis in rat liver by morphological, biochemical and molecular modelling studies

• Authors : Shahin Ahmadian; Mahshid Shafizadeh; Ahmad Reza Dehpour

Subjects: Male; 0301 basic medicine; Physiology

• Source: Clinical and Experimental Pharmacology and Physiology. 47:1575-1583

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Assessment of amiodarone-induced phospholipidosis in chimeric mice with a humanized liver

• Authors : Chise Tateno; Seigo Sanoh; Shigeru Ohta

• Source: The Journal of Toxicological Sciences. 2017, 42(5):589

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A cell-based assay using HepaRG cells for predicting drug-induced phospholipidosis

• Authors : Masahiro Iwaki; Masakazu Ishimura; Takafumi Tomida

• Source: The Journal of Toxicological Sciences. 2017, 42(5):641

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Amoxillin- and pefloxacin-induced cholesterogenesis and phospholipidosis in rat tissues.

• Authors : Rotimi, Solomon O.¹; Ojo, David A.²; Talabi, Olusola A.³

Subjects: *AMOXICILLIN; *CHOLESTEROL; *PHOSPHOLIPIDS

• Source: Lipids in Health & Disease. 2015, Vol. 14 Issue 1, p1-17. 17p. 1 Diagram, 12 Graphs.

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Side effects of oxysterols: cytotoxicity, oxidation, inflammation, and phospholipidosis

• Authors : A. Vejux; L. Malvitte; G. Lizard

Subjects: Apoptosis; Atherosclerosis; Inflammation

• Source: Brazilian Journal of Medical and Biological Research, Vol 41, Iss 7, Pp 545-556 (2008)

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Renal phospholipidosis and impaired magnesium handling in high-fat-diet-fed mice

• Authors : Kurstjens, S.; Smeets, B.; Overmars-Bos, C.

• Source: The Faseb Journal; 7192; 7201; 0892-6638; 6; 33; ~The Faseb Journal~7192~7201~~~0892-6638~6~33~~

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Zebra-like bodies in COVID-19: is phospholipidosis evidence of hydroxychloroquine induced acute kidney injury?

• Authors : Mohammad Obeidat; Marina Ivanovic; Stephanie J.T. Chen

Subjects: 0301 basic medicine; Phospholipidosis; medicine.medical_specialty

• Source: Ultrastructural Pathology

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Drug-induced phospholipidosis is not correlated with the inhibition of SARS-CoV-2 - inhibition of SARS-CoV-2 is cell line-specific

• Authors : Diesendorf, Viktoria; Roll, Valeria; Geiger, Nina

Subjects: ddc:610

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Case report of progressive renal dysfunction as a consequence of amiodarone-induced phospholipidosis

• Authors : Duineveld, Mirjam D; Kers, Jesper; Vleming, Louis-Jean ...

• Source: European Heart Journal - Case Reports ; volume 7, issue 9 ; ISSN 2514-2119

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High Content Analysis of Human Pluripotent Stem Cell Derived Hepatocytes Reveals Drug Induced Steatosis and Phospholipidosis

• Authors : Pradip, A; Steel, D; Jacobsson, S

Subjects: Medicin och hälsovetenskap

• Source: Stem cells international. 2016:2475631

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Assessment of amiodarone-induced phospholipidosis in chimeric mice with a humanized liver.

• Authors : Seigo Sanoh¹ ; Yuto Yamachika¹; Yuka Tamura¹

• Source: Journal of Toxicological Sciences. Oct2017, Vol. 42 Issue 5, p589-596. 8p.

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Characteristics of corneal phospholipidosis induced by topical ocular application of chloroquine and amiodarone in rabbits.

• Authors : Yoshinori Yamagiwa¹ ; Yu Haranosono¹; Shingo Nemoto¹

• Source: Journal of Toxicologic Pathology. 2017, Vol. 30 Issue 2, p135-143. 9p.

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Alterations in endo-lysosomal function induce similar hepatic lipid profiles in rodent models of drug-induced phospholipidosis and Sandhoff disease

• Authors : Emmanuelle Lecommandeur; David Baker; Timothy M. Cox

Subjects: ceramides; lipidomics; lysophospholipid

• Source: Journal of Lipid Research, Vol 58, Iss 7, Pp 1306-1314 (2017)

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Different Sensitivity of Macrophages to Phospholipidosis Induction by Amphiphilic Cationic Drugs

• Authors : Kristin Öhlinger; Markus Absenger-Novak; Claudia Meindl

Subjects: inhalation; toxicity; phospholipidosisagris

• Source: International Journal of Molecular Sciences; Volume 21; Issue 21; Pages: 8391

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Use of 3D Human Liver Organoids to Predict Drug-Induced Phospholipidosis

• Authors : Ji-Young Lee; Hyo-Jeong Han; Sang-Joon Lee

Subjects: 3D human liver organoids; drug-induced phospholipidosis; HepG2agris

• Source: International Journal of Molecular Sciences; Volume 21; Issue 8; Pages: 2982

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Characteristics of corneal phospholipidosis induced by topical ocular application of chloroquine and amiodarone in rabbits

• Authors : Gakushi Kito; Haruko Koizumi; Hideyuki Sakaki

• Source: Journal of Toxicologic Pathology. 2017, 30(2):135

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Glucosylceramide and Lysophosphatidylcholines as Potential Blood Biomarkers for Drug-Induced Hepatic Phospholipidosis.

• Authors : Saito, Kosuke¹; Maekawa, Keiko¹; Ishikawa, Masaki¹

Subjects: *GLUCOSYLCERAMIDES; *LECITHIN; *BLOOD testing

• Source: Toxicological Sciences. Oct2014, Vol. 141 Issue 2, p377-386. 10p.

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A cell-based assay using HepaRG cells for predicting drug-induced phospholipidosis.

• Authors : Takafumi Tomida¹ ; Masakazu Ishimura¹; Masahiro Iwaki²

• Source: Journal of Toxicological Sciences. Oct2017, Vol. 42 Issue 5, p641-650. 10p.

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Establishment of an in silico phospholipidosis prediction method using descriptors related to molecular interactions causing phospholipid–compound complex formation

• Authors : Hideyuki Sakaki; Masaaki Kurata; Shingo Nemoto

• Source: The Journal of Toxicological Sciences. 2016, 41(2):321

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Detection of metabolic activation leading to drug-induced phospholipidosis in rat hepatocyte spheroids

• Authors : Masashi Takagi; Masataka Santoh; Seigo Sanoh

• Source: The Journal of Toxicological Sciences. 2016, 41(1):155

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Synthesis of di-docosahexaenoyl (C22:6)-bis(monoacylglycerol) phosphate in unlabelled and C-13 labelled forms for use as a biomarker of drug induced phospholipidosis

• Authors : Johnny Lindqvist; Charles S. Elmore; Håkan Andersson

Subjects: Salt (chemistry); Ether; Alcohol

• Source: Journal of Labelled Compounds and Radiopharmaceuticals. 62:695-706

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Comparison of oral, intranasal and aerosol administration of amiodarone in rats as a model of pulmonary phospholipidosis

• Authors : Patel, Aateka; Hoffman, Ewelina; Ball, Doug

Subjects: Amiodarone; Di-22:6 bis-monoacylglycerol; Foamy alveolar macrophages

• Source: Patel , A , Hoffman , E , Ball , D , Klapwijk , J , Steven , R T , Dexter , A , Bunch , J , Baker , D , Murnane , D , Hutter , V , Page , C , Dailey , L A & Forbes , B 2019 , ' Comparison of oral,

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AMALPHI: A Machine Learning Platform for Predicting Drug-Induced PhospholIpidosis

• Authors : Lomuscio, Maria Cristina; Abate, Carmen; Alberga, Domenico ...

• Source: Molecular Pharmaceutics ; volume 21, issue 2, page 864-872 ; ISSN 1543-8384 1543-8392

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Phospholipidosis Induced by PPARγ Signaling in Human Bronchial Epithelial (BEAS-2B) Cells Exposed to Amiodarone.

• Authors : Song, Mee¹; Kim, Youn-Jung²; Ryu, Jae-Chun¹

Subjects: *CELLULAR signal transduction; *AMIODARONE; *LIPID metabolism

• Source: Toxicological Sciences. Mar2011, Vol. 120 Issue 1, p98-108. 11p.

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A Toxicogenomic Approach to Drug-Induced Phospholipidosis: Analysis of Its Induction Mechanism and Establishment of a Novel in Vitro Screening System.

• Authors : Sawada, Hiroshi¹ Sawada•; Takami, Kenji²; Asahi, Satoru³

Subjects: *PHOSPHOLIPIDS; *POLYMERASE chain reaction; *IN vitro toxicity testing

• Source: Toxicological Sciences. Feb2005, Vol. 83 Issue 2, p282-292. 11p. 2 Diagrams, 6 Charts, 2 Graphs.

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Establishment of an in silico phospholipidosis prediction method using descriptors related to molecular interactions causing phospholipid-compound complex formation.

• Authors : Yu Haranosono¹ ; Shingo Nemoto¹; Masaaki Kurata¹

• Source: Journal of Toxicological Sciences. Apr2016, Vol. 41 Issue 2, p321-328. 8p.

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In vitro validation of drug-induced phospholipidosis.

• Authors : Sora Park¹; You-Jin Choi¹; Byung-Hoon Lee¹

• Source: Journal of Toxicological Sciences. Apr2012, Vol. 37 Issue 2, p261-267. 7p.

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Establishment of an In Vitro High-Throughput Screening Assay for Detecting Phospholipidosis-Inducing Potential.

• Authors : Kasahara, Toshihiko¹ ; Tomita, Kazuo¹; Murano, Hiroyuki²

Subjects: *PHOSPHOLIPIDS; *CHRONIC diseases; *FIRE assay

• Source: Toxicological Sciences. Mar2006, Vol. 90 Issue 1, p133-141. 9p. 1 Diagram, 1 Chart, 1 Graph.

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