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High-throughput neural stem cell-based drug screening identifies S6K1 inhibition as a selective vulnerability in sonic hedgehog-medulloblastoma

• Authors : Zhou, LL; van Bree, N; Boutin, L

Subjects: Medicin och hälsovetenskap

• Source: Neuro-oncology. 26(9):1685-1699

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Dynamic microphysiological system chip platform for high-throughput, customizable, and multi-dimensional drug screening

• Authors : Yuxuan Zhu; Deming Jiang; Yong Qiu

Subjects: Microphysiological system; Organ-on-a-chip; Biomimetics

• Source: Bioactive Materials, Vol 39, Iss , Pp 59-73 (2024)

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A 3D Pancreatic Cancer Model with Integrated Optical Sensors for Noninvasive Metabolism Monitoring and Drug Screening

• Authors : Siciliano, Anna Chiara; Forciniti, Stefania; Onesto, Valentina

Subjects: Quantitative Biology - Quantitative Methods

• Source: Advanced Healthcare Materials 2024, 2401138

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Drug Screening System Method Comparison

• Source: User Performance Evaluation of the Intelligent Fingerprinting Drug Screening System: Method Comparison and Usability

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Network Medicine: A Potential Approach for Virtual Drug Screening.

• Authors : Ma, Mingxuan¹ (AUTHOR) ; Huang, Mei¹ (AUTHOR) ; He, Yinting¹ (AUTHOR)

• Source: Pharmaceuticals (14248247). Jul2024, Vol. 17 Issue 7, p899. 14p.

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Human Hepatobiliary Organoids: Recent Advances in Drug Toxicity Verification and Drug Screening.

• Authors : Fang, Haoyu^1,2 (AUTHOR) ; Xu, Haoying³ (AUTHOR) ; Yu, Jiong^2,3,4 (AUTHOR)

• Source: Biomolecules (2218-273X). Jul2024, Vol. 14 Issue 7, p794. 19p.

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基于类器官芯片的药物筛选及其中的生物化学原理.

• Authors : 渠志倍¹ ; 王昌鑫¹; 醴磊¹

• Source: University Chemistry. 2024, Vol. 39 Issue 7, p278-286. 9p.

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Skeletal muscle-on-a-chip in microgravity as a platform for regeneration modeling and drug screening

• Authors : Kim, Soochi; Ayan, Bugra; Shayan, Mahdis

Subjects: Biochemistry and Cell Biology; Biological Sciences; Bioengineering

• Source: Stem Cell Reports. 19(8)

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Discovery of Antibacterial Compounds with Potential Multi-Pharmacology against Staphylococcus Mur ligase Family Members by In Silico Structure-Based Drug Screening.

• Authors : Teshima, Mio¹ (AUTHOR); Monobe, Kohei¹ (AUTHOR); Okubo, Saya¹ (AUTHOR)

Subjects: *AMINO acid sequence; *MOLECULAR dynamics; *STAPHYLOCOCCUS epidermidis

• Source: Molecules. Aug2024, Vol. 29 Issue 16, p3792. 14p.

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EPIDetect: Video-based convulsive seizure detection in chronic epilepsy mouse model for anti-epilepsy drug screening

• Authors : Ren, Junming; Xiao, Zhoujian; Zhang, Yujia

Subjects: Computer Science - Computer Vision and Pattern Recognition

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A Pilot of a Microdevice For In Situ Candidate Drug Screening in Cutaneous Lesions of T-Cell Lymphoma

• Authors : Cecilia Larocca, MD, Principal Investigator

• Source: A Pilot of a Microdevice For In Situ Candidate Drug Screening in Cutaneous Lesions of T-Cell Lymphoma

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High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma

• Authors : Arang, Nadia; Lubrano, Simone; Ceribelli, Michele

Subjects: Biomedical and Clinical Sciences; Rare Diseases; Cancer

• Source: Cell Reports Medicine. 4(11)

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CRISPR/Cas9-Mediated fech Knockout Zebrafish: Unraveling the Pathogenesis of Erythropoietic Protoporphyria and Facilitating Drug Screening.

• Authors : Wijerathna, Hitihami M. S. M.^1,2 (AUTHOR) ; Shanaka, Kateepe A. S. N.^1,3 (AUTHOR); Raguvaran, Sarithaa S.^1,3 (AUTHOR)

Subjects: *CRISPRS; *REVERSE transcriptase polymerase chain reaction; *ERYTHROPOIETIC protoporphyria

• Source: International Journal of Molecular Sciences. Oct2024, Vol. 25 Issue 19, p10819. 27p.

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Personalized Targeted Glioblastoma Therapies by ex Vivo Drug Screening (ATTRACT)

• Authors : Anna Berghoff, Assoc.-Prof. PD DDr.

• Source: Personalized Targeted Glioblastoma Therapies by ex Vivo Drug Screening: Advanced Brain Tumor TheRApy Clinical Trial (ATTRACT)

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Reliability of AlphaFold2 Models in Virtual Drug Screening: A Focus on Selected Class A GPCRs.

• Authors : Alhumaid, Nada K.¹ (AUTHOR) ; Tawfik, Essam A.¹ (AUTHOR)

Subjects: *G protein coupled receptors; *MOLECULAR structure; *DRUG discovery

• Source: International Journal of Molecular Sciences. Sep2024, Vol. 25 Issue 18, p10139. 21p.

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Gastrointestinal Cancer Patient Derived Organoids at the Frontier of Personalized Medicine and Drug Screening.

• Authors : Yang, Zhenjie¹ (AUTHOR) ; Yu, Jun^1,2 (AUTHOR) ; Wong, Chi Chun^1,2 (AUTHOR)

• Source: Cells (2073-4409). Aug2024, Vol. 13 Issue 16, p1312. 18p.

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Advancing Cardiovascular Drug Screening Using Human Pluripotent Stem Cell-Derived Cardiomyocytes.

• Authors : Oh, Jisun¹ (AUTHOR) ; Kwon, Oh-Bin¹ (AUTHOR) ; Park, Sang-Wook² (AUTHOR)

Subjects: *DRUG use testing; *DRUG side effects; *CARDIOVASCULAR agents

• Source: International Journal of Molecular Sciences. Jul2024, Vol. 25 Issue 14, p7971. 16p.

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Deep learning-based drug screening for the discovery of potential therapeutic agents for Alzheimer's disease

• Authors : Tong Wu; Ruimei Lin; Pengdi Cui

Subjects: Alzheimer's disease; Deep learning models; Drug screening

• Source: Journal of Pharmaceutical Analysis, Vol 14, Iss 10, Pp 101022- (2024)

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Tissue Collection for Drug Screening and Bioanalysis

• Source: Tissue Collection for Drug Screening and BioanalysisRajappa P, Cobb WS, Vartanian E, Huang Y, Daly L, Hoffman C, Zhang J, Shen B,

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Drug-screening in AML at Relapse for Targeted Treatment (DARTT-1)

• Source: Drug-screening in AML at Relapse for Targeted Treatment

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GAS-Luc2 Reporter Cell Lines for Immune Checkpoint Drug Screening in Solid Tumors.

• Authors : Chang, Hyeyoun¹ (AUTHOR); Foulke, John G.¹ (AUTHOR); Chen, Luping¹ (AUTHOR)

• Source: Cancers. Jun2024, Vol. 16 Issue 11, p1965. 19p.

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Identification of Novel Antimicrobial Compounds Targeting Mycobacterium tuberculosis S -Adenosyl-L-Homocysteine Hydrolase Using Dual Hierarchical In Silico Structure-Based Drug Screening.

• Authors : Ito, Hazuki¹ (AUTHOR); Monobe, Kohei¹ (AUTHOR); Okubo, Saya¹ (AUTHOR)

Subjects: *MYCOBACTERIUM tuberculosis; *POISONS; *MYCOBACTERIUM smegmatis

• Source: Molecules. Mar2024, Vol. 29 Issue 6, p1303. 12p.

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A Zebrafish-Based Platform for High-Throughput Epilepsy Modeling and Drug Screening in F0.

• Authors : Locubiche, Sílvia^1,2 (AUTHOR) ; Ordóñez, Víctor¹ (AUTHOR) ; Abad, Elena¹ (AUTHOR)

Subjects: *CHILDHOOD epilepsy; *DRUG discovery; *EPILEPSY

• Source: International Journal of Molecular Sciences. Mar2024, Vol. 25 Issue 5, p2991. 25p.

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Efficacy of Organoid-Based Drug Screening to Guide Treatment for Locally Advanced Thyroid Cancer

• Authors : Li Zhihui, Dean of the Thyroid Surgery Department

• Source: Precision Medicine Applied to Locally Advanced Thyroid Cancer Using Tumor-derived Organoids and In-vitro Sensitivity Testing: a Phase 2a, Single-center, Open-label, and Non-comparative Study

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Spheroids and organoids derived from colorectal cancer as tools for in vitro drug screening

• Authors : Sahira Syamimi Ahmad Zawawi; Elyn Amiela Salleh; Marahaini Musa

Subjects: organoid; colon cancer; drug screening

• Source: Exploration of Targeted Anti-tumor Therapy, Vol 5, Iss 2, Pp 409-431 (2024)

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Who gets screened and who tests positive? Drug screening among justice-involved youth in a midwestern urban county

• Authors : Richelle L. Clifton; Ian Carson; Allyson L. Dir

Subjects: Drug screening; Juvenile justice; Juvenile probation

• Source: Health & Justice, Vol 12, Iss 1, Pp 1-12 (2024)

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Decellularized extracellular matrix-based disease models for drug screening

• Authors : Zhoujiang Chen; Ji Wang; Ranjith Kumar Kankala

Subjects: Drug screening; Extracellular matrix; Cell models

• Source: Materials Today Bio, Vol 29, Iss , Pp 101280- (2024)

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Recent advances in 3D bioprinting of tissues and organs for transplantation and drug screening

• Authors : Xuming Sun; Wu Ren; Linyan Xie

Subjects: 3D Bioprinting; Organ transplantation; Drug screening

• Source: Virtual and Physical Prototyping, Vol 19, Iss 1 (2024)

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Zero-shot Learning of Drug Response Prediction for Preclinical Drug Screening

• Authors : Li, Kun; Luo, Yong; Cai, Xiantao

Subjects: Quantitative Biology - Biomolecules; Computer Science - Artificial Intelligence; Computer Science - Machine Learning

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Residents' Knowledge regarding Recreational Drug Screening Immunoassays at a Swiss Hospital Group.

• Authors : Bekka, Elias¹ (AUTHOR); Christen, Samuel E.^1,2 (AUTHOR); Hermann, Laura¹ (AUTHOR)

• Source: International Journal of Analytical Chemistry. 6/10/2024, Vol. 2024, p1-7. 7p.

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Establishment of primary breast cancer cell line as new model for drug screening and basic research.

• Authors : HAO Xian¹; HUANG Jianjun²; YANG Wenxiu¹

• Source: China Oncology. 2024, Vol. 34 Issue 6, p561-570. 10p.

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Targeted Drug Screening Leveraging Senescence-Induced T-Cell Exhaustion Signatures in Hepatocellular Carcinoma.

• Authors : Qi, Qi¹ (AUTHOR) ; Pang, Jianyu¹ (AUTHOR); Chen, Yongzhi¹ (AUTHOR)

Subjects: *T-cell exhaustion; *HEPATOCELLULAR carcinoma; *CELLULAR aging

• Source: International Journal of Molecular Sciences. Oct2024, Vol. 25 Issue 20, p11232. 19p.

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A high-throughput system for drug screening based on the movement analysis of zebrafish

• Authors : Xinkai Zhao; Ziyu Li; Bingbing Cao

Subjects: Zebrafish; High-throughput; Drug screening

• Source: Heliyon, Vol 10, Iss 16, Pp e36495- (2024)

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A deep learning drug screening framework for integrating local-global characteristics: A novel attempt for limited data

• Authors : Ying Wang; Yangguang Su; Kairui Zhao

Subjects: COVID-19; Virtual drug screening; Deep learning

• Source: Heliyon, Vol 10, Iss 14, Pp e34244- (2024)

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Comprehensive Genomic Profiling and Next Generation Functional Drug Screening for Patients With Aggressive Haematological Malignancies (EXALT-2)

• Authors : Roche Pharma AG; Allcyte GmbH; Philipp Staber, MD, PhD, Assoc. Prof. Priv.-Doz. Dr.med.univ. Philipp Staber

• Source: Comprehensive Genomic Profiling and Next Generation Functional Drug Screening for Patients With Aggressive Haematological Malignancies:

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Synergistic drug interactions of the histone deacetylase inhibitor givinostat (ITF2357) in CRLF2-rearranged pediatric B-cell precursor acute lymphoblastic leukemia identified by high-throughput drug screening

• Authors : Athanasios Oikonomou; Titus Watrin; Luigia Valsecchi

Subjects: High-throughput drug screening; CRLF2 rearranged acute lymphoblastic leukemia; Combination treatment

• Source: Heliyon, Vol 10, Iss 13, Pp e34033- (2024)

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Real-time label-free three-dimensional invasion assay for anti-metastatic drug screening using impedance sensing

• Authors : Kai Ding; Hailong Li; Qian Xu

Subjects: tumor metastasis; tumor spheroid; biosensing

• Source: Frontiers in Pharmacology, Vol 15 (2024)

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Unveiling Epigenetic Vulnerabilities in Triple-Negative Breast Cancer through 3D Organoid Drug Screening.

• Authors : Rao, Xinxin^1,2,3 (AUTHOR) ; Qiao, Zhibin^1,2,3 (AUTHOR) ; Yang, Yang^1,2,3 (AUTHOR)

• Source: Pharmaceuticals (14248247). Feb2024, Vol. 17 Issue 2, p225. 16p.

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ZEBRA FISH: AN EXPERIMENTAL MODEL FOR DRUG SCREENING.

• Authors : Narkhede, Mahesh B.¹ ; Chinchole, Pavan P.¹; Deokar, Mangesh N.¹

• Source: Journal of Advanced Scientific Research. Dec2023, Vol. 14 Issue 11, p1-6. 6p.

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Phosphorylated protein chip combined with artificial intelligence tools for precise drug screening.

• Authors : Katsuhisa Horimoto^1,2,3 ; Yuki Suyama¹; Tadamasa Sasaki¹

• Source: Journal of Biomedical Research. May2024, Vol. 38 Issue 3, p195-205. 11p.

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High-throughput drug screening identifies novel therapeutics for Low Grade Serous Ovarian Carcinoma

• Authors : Kathleen I. Pishas; Karla J. Cowley; Marta Llaurado-Fernandez

Subjects: Science

• Source: Scientific Data, Vol 11, Iss 1, Pp 1-15 (2024)

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Development of Fusion-Based Assay as a Drug Screening Platform for Nipah Virus Utilizing Baculovirus Expression Vector System.

• Authors : Sari, Indah Permata^1,2 (AUTHOR) ; Ortiz, Christopher Llynard D.^3,4,5 (AUTHOR) ; Yang, Lee-Wei^3,4 (AUTHOR)

Subjects: *NIPAH virus; *RECOMBINANT proteins; *CHIMERIC proteins

• Source: International Journal of Molecular Sciences. Aug2024, Vol. 25 Issue 16, p9102. 16p.

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RESEARCH PROGRESS IN INDIVIDUALIZED DRUG SCREENING TECHNOLOGY FOR PATIENTS WITH TUMORS

• Authors : WU Xiao-xiao, LIU Meiyou, PENG Li, CHENG Lianghua, WANG Fan, WANG Jingwen, JIA Yanyan

Subjects: neoplasms; drug screening assays, antitumor; genome aequencing

• Source: 精准医学杂志, Vol 38, Iss 6, Pp 556-559 (2023)

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Tumor Microenvironment Based on Extracellular Matrix Hydrogels for On-Chip Drug Screening

• Authors : Xiaoyan Liu; Jinxiong Cheng; Yingcan Zhao

Subjects: microfluidics; dECM hydrogels; drug screening

• Source: Biosensors, Vol 14, Iss 9, p 429 (2024)

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High-throughput drug screening to investigate blood-brain barrier permeability in vitro with a focus on breast cancer chemotherapeutic agents

• Authors : Carolin J. Curtaz; Sophia Wucherpfennig; Emad Al-Masnaea

Subjects: metastatic breast cancer; blood-brain barrier; in vitro models

• Source: Frontiers in Drug Delivery, Vol 4 (2024)

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Personalized Cancer Stem Cell High-Throughput Drug Screening for Glioblastoma

• Source: A Phase 1 Study of Combination Drug Therapy Based on Personalized Cancer Stem Cell (CSC) High-Throughput Drug

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Cancer Stem Cell High-Throughput Drug Screening Study

• Source: A Phase 0/1 Study of Combination Drug Therapy For Glioblastoma Based on Personalized Cancer Stem Cell (CSC) High-Throughput Drug

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Single molecule tracking based drug screening

• Authors : Daisuke Watanabe; Michio Hiroshima; Masato Yasui

Subjects: Science

• Source: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

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Engineered bone marrow as a clinically relevant ex vivo model for primary bone cancer research and drug screening

• Authors : Griffin, Katherine H; Thorpe, Steven W; Sebastian, Aimy

Subjects: Biomedical and Clinical Sciences; Engineering; Oncology and Carcinogenesis

• Source: Proceedings of the National Academy of Sciences of the United States of America. 120(39)

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The Temozolomide–Doxorubicin paradox in Glioblastoma in vitro–in silico preclinical drug-screening

• Authors : Mariam-Eleni Oraiopoulou; Eleftheria Tzamali; Stylianos E. Psycharakis

Subjects: Brain cancer; Preclinical drug-screening; Computational models

• Source: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)

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