نتائج البحث

Macrocyclic Peptidomimetic Plasmepsin X Inhibitors with Potent In Vitro and In Vivo Antimalarial Activity

• Authors : Kovada, Vadims; Withers-Martinez, Chrislaine; Bobrovs, Raitis ...

• Source: Journal of Medicinal Chemistry ; volume 66, issue 15, page 10658-10680 ; ISSN 0022-2623 1520-4804

تفاصيل العنوان

Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183

• Authors : de Vries, Laura, E; Jansen, Patrick, a M; Barcelo, Catalina ...

Subjects: [SDV]Life Sciences [q-bio]

• Source: ISSN: 2041-1723.

تفاصيل العنوان

Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362

• Authors : Lowe, Martin A; Cardenas, Alvaro; Valentin, Jean-Pierre

Subjects: info:eu-repo/classification/ddc/616

• Source: ISSN: 0022-2623 ; Journal of medicinal chemistry, (2022.

تفاصيل العنوان

Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncomplicated Malaria

• Authors : Taft, Benjamin R.; Yokokawa, Fumiaki; Kirrane, Tom ...

• Source: Journal of Medicinal Chemistry ; volume 65, issue 5, page 3798-3813 ; ISSN 0022-2623 1520-4804

تفاصيل العنوان

Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362

• Authors : Lowe, Martin A.; Cardenas, Alvaro; Valentin, Jean-Pierre ...

• Source: Journal of Medicinal Chemistry ; volume 65, issue 20, page 14121-14143 ; ISSN 0022-2623 1520-4804

تفاصيل العنوان

The multistate tuberculosis pharmacometric model: a semi-mechanistic pharmacokinetic-pharmacodynamic model for studying drug effects in an acute tuberculosis mouse model

• Authors : Chen, Chunli; Ortega, Fatima; Rullas, Joaquin

Subjects: Mouse; Rifampicin; Tuberculosis

• Source: Journal of Pharmacokinetics and Pharmacodynamics. 44(2):133-141

تفاصيل العنوان

A novel multiple-stage antimalarial agent that inhibits protein synthesis

• Authors : Baragaña, Beatriz; Hallyburton, Irene; Lee, Marcus CS

Subjects: Medical Microbiology; Biomedical and Clinical Sciences; Clinical Sciences

• Source: Nature. 522(7556)

تفاصيل العنوان

(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium

• Authors : Jiménez-Díaz, María Belén; Ebert, Daniel; Salinas, Yandira

Subjects: Medical Microbiology; Biomedical and Clinical Sciences; Clinical Sciences

• Source: Proceedings of the National Academy of Sciences of the United States of America. 111(50)

تفاصيل العنوان

Study of Tissue-Specific Reactive Oxygen Species Formation by Cell Membrane Microarrays for the Characterization of Bioactive Compounds

• Authors : Elexpe, Ane; Nieto, Nerea; Fernández Cuétara, Claudia

Subjects: microarray; inhibitors; antimalarial

تفاصيل العنوان

Enzyme Therapy: Current Challenges and Future Perspectives

• Authors : De la Fuente López, Miguel; Lombardero, Laura; Gómez-González, Alfonso

Subjects: biotechnology; enzyme therapy; encapsulation

تفاصيل العنوان

Chemoprotective antimalarial activity of P218 against Plasmodium falciparum : a randomized, placebo-controlled volunteer infection study

• Authors : Chughlay, Mohamed Farouk; El Gaaloul, Myriam; Donini, Cristina

Subjects: Human medicine

• Source: 0002-9637 ; The American journal of tropical medicine and hygiene

تفاصيل العنوان

Pharmacokinetic / pharmacodynamic relationships of liposomal amphotericin B and miltefosine in experimental visceral leishmaniasis.

• Authors : Voak, Andrew A; Harris, Andy; Coteron-Lopez, Jose Miguel

تفاصيل العنوان

Pharmacokinetic / pharmacodynamic relationships of liposomal amphotericin B and miltefosine in experimental visceral leishmaniasis

• Authors : Voak, Andrew A.; Harris, Andy; Coteron-Lopez, Jose Miguel ...

• Source: PLOS Neglected Tropical Diseases ; volume 15, issue 3, page e0009013 ; ISSN 1935-2735

تفاصيل العنوان

A new in vivo screening paradigm to accelerate antimalarial drug discovery.

• Authors : Jiménez-Díaz, María; Viera, Sara; Ibáñez, Javier

Subjects: Animals; Antimalarials; Drug Evaluation

• Source: PLoS One. 8(6)

تفاصيل العنوان

A novel class of fast‐acting antimalarial agents: Substituted 15‐membered azalides

• Authors : Peric, Mihaela; Pešić, Dijana; Alihodžić, Sulejman

• Source: British Journal of Pharmacology ; volume 178, issue 2, page 363-377 ; ISSN 0007-1188 1476-5381

تفاصيل العنوان

Chemical genetics of Plasmodium falciparum

• Authors : Guiguemde, W Armand; Shelat, Anang A; Bouck, David

Subjects: Medical Microbiology; Biomedical and Clinical Sciences; Clinical Sciences

• Source: Nature. 465(7296)

تفاصيل العنوان

A murine model of falciparum-malaria by in vivo selection of competent strains in non-myelodepleted mice engrafted with human erythrocytes.

• Authors : Angulo-Barturen, Iñigo; Jiménez-Díaz, María Belén; Mulet, Teresa

Subjects: Animals; Mice; Inbred NOD

• Source: PloS one. 3(5)

تفاصيل العنوان

Antimalarial pantothenamide metabolites target acetyl-coenzyme A biosynthesis in Plasmodium falciparum

• Authors : Schalkwijk, Joost; Allman, Erik L.; Jansen, Patrick A.M.

Subjects: Life Science

• Source: Science Translational Medicine 11 (2019) 510 ; ISSN: 1946-6234

تفاصيل العنوان

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

• Authors : Baragaña, Beatriz; Forte, Barbara; Choi, Ryan

تفاصيل العنوان

UCT943, a next generation Plasmodium falciparum PI4K inhibitor preclinical candidate for the treatment of malaria

• Authors : Brunschwig, Christel; Lawrence, Nina; Taylor, Dale

تفاصيل العنوان

Erratum for Brunschwig et al., 'UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria'

• Authors : Brunschwig, Christel; Lawrence, Nina; Taylor, Dale

• Source: Brunschwig , C , Lawrence , N , Taylor , D , Abay , E , Njoroge , M , Basarab , G S , Le Manach , C , Paquet , T , Gonzàlez Cabrera , D , Nchinda , A T , de Kock , C , Wiesner , L , Denti , P ,

تفاصيل العنوان

Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria.

• Authors : O' Neill, Paul M; Stocks, Paul A; Sabbani, Sunil

Subjects: WA 110 Prevention and control of communicable diseases. Transmission of infectious diseases; WC 750 Malaria; WC 770 Therapy

• Source: Bioorganic and Medicinal Chemistry, Vol 26, Issue 11, pp. 2996-3005.

تفاصيل العنوان

A Plasmodium berghei sporozoite-based vaccination platform against human malaria

• Authors : Mendes, António M.; Machado, Marta; Gonçalves-Rosa, Nataniel

Subjects: Pharmacology (medical); Infectious Diseases; Pharmacology

• Source: npj Vaccines ; volume 3, issue 1 ; ISSN 2059-0105

تفاصيل العنوان

Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase

• Authors : Paquet, Tanya; Le Manach, Claire; Cabrera, Diego González

Subjects: /dk/atira/pure/subjectarea/asjc/2700/2700; name=General Medicine

• Source: Paquet , T , Le Manach , C , Cabrera , D G , Younis , Y , Henrich , P P , Abraham , T S , Lee , M C S , Basak , R , Ghidelli-Disse , S , Lafuente-Monasterio , M J , Bantscheff , M , Ruecker , A ,

تفاصيل العنوان

A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance.

• Authors : O'Neill, Paul M; Amewu, Richard K; Charman, Susan A

Subjects: QV 256 Antimalarials; QV 38 Drug action; QX 20 Research (General)

• Source: Nature Communications, Vol 8, e15159.

تفاصيل العنوان

A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission.

• Authors : Baker, David A; Stewart, Lindsay B; Large, Jonathan M

تفاصيل العنوان

A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance

• Authors : O’Neill, Paul M.; Amewu, Richard K.; Charman, Susan A.

Subjects: General Physics and Astronomy; General Biochemistry, Genetics and Molecular Biology; General Chemistry

• Source: Nature Communications ; volume 8, issue 1 ; ISSN 2041-1723

تفاصيل العنوان

A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission

• Authors : Baker, David A.; Stewart, Lindsay B.; Large, Jonathan M.

Subjects: General Physics and Astronomy; General Biochemistry, Genetics and Molecular Biology; General Chemistry

• Source: Nature Communications ; volume 8, issue 1 ; ISSN 2041-1723

تفاصيل العنوان

Correction to The Discovery of Novel Antimalarial Aminoxadiazoles as a Promising Nonendoperoxide Scaffold

• Authors : Sandoval, Elena; Lafuente-Monasterio, María José; Almela, María J.

• Source: Journal of Medicinal Chemistry ; volume 60, issue 23, page 9911-9911 ; ISSN 0022-2623 1520-4804

تفاصيل العنوان

Trisubstituted Pyrimidines as Efficacious and Fast-acting Antimalarials

• Authors : Norcross, Neil R.; Baragana, Beatriz; Wilson, Caroline

• Source: Norcross , N R , Baragana , B , Wilson , C , Hallyburton , I , Osuna-Cabello , M , Norval , S , Riley , J , Stojanovski , L , Simeons , F R C , Porzelle , A , Grimaldi , R , Wittlin , S , Duffy , S ,

تفاصيل العنوان

Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose–Efficacy Modeling

• Authors : Le Bihan, Amélie; de Kanter, Ruben; Angulo-Barturen, Iñigo

تفاصيل العنوان

Identification of KasA as the cellular target of an anti-tubercular scaffold

• Authors : Abrahams, Katherine A.; Chung, Chun-Wa; Ghidelli-Disse, Sonja

تفاصيل العنوان

Antitubercular drugs for an old target : GSK693 as a promising InhA direct inhibitor

• Authors : Martínez-Hoyos, María; Perez-Herran, Esther; Gulten, Gulcin

Subjects: Tuberculosis; Antibiotic; InhA

تفاصيل العنوان

Erratum: Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis

• Authors : Baragaña, Beatriz; Hallyburton, Irene; Lee, Marcus C. S.

Subjects: Multidisciplinary

• Source: Nature ; volume 537, issue 7618, page 122-122 ; ISSN 0028-0836 1476-4687

تفاصيل العنوان

Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase

• Authors : Palencia, Andrés; Li, Xianfeng; Bu, Wei

• Source: Antimicrobial Agents and Chemotherapy ; volume 60, issue 10, page 6271-6280 ; ISSN 0066-4804 1098-6596

تفاصيل العنوان

Linking Murine and Human Plasmodium falciparum Challenge Models in a Translational Path for Antimalarial Drug Development

• Authors : McCarthy, James S.; Marquart, Louise; Sekuloski, Silvana ...

• Source: Antimicrobial Agents and Chemotherapy ; volume 60, issue 6, page 3669-3675 ; ISSN 0066-4804 1098-6596

تفاصيل العنوان

Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity

• Authors : Kokkonda, Sreekanth; Deng, Xiaoyi; White, Karen L. ...

• Source: Journal of Medicinal Chemistry ; volume 59, issue 11, page 5416-5431 ; ISSN 0022-2623 1520-4804

تفاصيل العنوان

Pharmacokinetic-pharmacodynamic and dose-response relationships of antituberculosis drugs: recommendations and standards for industry and academia

• Authors : Gumbo, Tawanda; Angulo Barturen, Iñigo; Ferrer Bazaga, Santiago

Subjects: Antituberculosis agents; Clinical correlations; Dose identification

تفاصيل العنوان

Identifying rapidly parasiticidal anti-malarial drugs using a simple and reliable in vitro parasite viability fast assay

• Authors : Viera, Sara; Crespo, Benigno; Franco, Virginia

Subjects: 636.09; Drug discovery; Malaria

تفاصيل العنوان

Immunoliposome-mediated drug delivery to Plasmodium-infected and non-infected red blood cells as a dual therapeutic/prophylactic antimalarial stragegy

• Authors : Moles Meler, Ernest; Urbán, Patricia; Jiménez-Díaz, Maria Belén

Subjects: Malària; Nanomedicina; Plasmodium falciparum

• Source: Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

تفاصيل العنوان

Histone methyltransferase inhibitors are orally bioavailable, fast- Acting molecules with activity against different species causing malaria in humans

• Authors : Malmquist, Nicholas A; Sundriyal, Sandeep; Caron, Joachim

Subjects: Microbiology; Microbiology not elsewhere classified; Medical microbiology

تفاصيل العنوان

Identifying rapidly parasiticidal anti-malarial drugs using a simple and reliable in vitro parasite viability fast assay

• Authors : Linares, María; Viera, Sara; Crespo, Benigno

Subjects: Infectious Diseases; Parasitology

• Source: Malaria Journal ; volume 14, issue 1 ; ISSN 1475-2875

تفاصيل العنوان

Combinations of β-Lactam Antibiotics Currently in Clinical Trials Are Efficacious in a DHP-I-Deficient Mouse Model of Tuberculosis Infection

• Authors : Rullas, Joaquín; Dhar, Neeraj; McKinney, John D.

• Source: Antimicrobial Agents and Chemotherapy ; volume 59, issue 8, page 4997-4999 ; ISSN 0066-4804 1098-6596

تفاصيل العنوان

Repositioning: the fast track to new anti-malarial medicines?

• Authors : Lotharius, Julie; Gamo Benito, Francisco Javier; Angulo Barturen, Iñigo

Subjects: Anti-malarial drugs; Candidate drug re-profiling; Drug repositioning

تفاصيل العنوان

Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum

• Authors : Vaidya, Akhil B.; Morrisey, Joanne M.; Zhang, Zhongsheng

تفاصيل العنوان

Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum.

• Authors : Vaidya, Akhil B; Morrisey, Joanne M; Zhang, Zhongsheng

تفاصيل العنوان

Pulmonary Mycobacterium bovis BCG Vaccination Confers Dose-Dependent Superior Protection Compared to That of Subcutaneous Vaccination

• Authors : Aguilo, Nacho; Toledo, Ana Maria; Lopez-Roman, Eva Maria ...

• Source: Clinical and Vaccine Immunology ; volume 21, issue 4, page 594-597 ; ISSN 1556-6811 1556-679X

تفاصيل العنوان

A new in vivo screening paradigm to accelerate antimalarial drug discovery

• Authors : Jiménez Diaz, María Belén; Viera, Sara; Ibáñez, Javier

Subjects: Biología y Biomedicina; Farmacia; Medicina

تفاصيل العنوان

Quinolone-3-Diarylethers: a new class of antimalarial drug

• Authors : Nilsen, Aaron; LaCrue, Alexis N; White, Karen L

Subjects: Medicinal and biomolecular chemistry not elsewhere classified; Biological sciences; Biomedical and clinical sciences

تفاصيل العنوان

Tetrahydropyrazolo[1,5-a]Pyrimidine-3-Carboxamide and N-Benzyl-6′,7′-Dihydrospiro[Piperidine-4,4′-Thieno[3,2-c]Pyran] Analogues with Bactericidal Efficacy against Mycobacterium tuberculosis Targeting MmpL3

• Authors : Remuiñán, Modesto J.; Pérez-Herrán, Esther; Rullás, Joaquín ...

• Source: PLoS ONE ; volume 8, issue 4, page e60933 ; ISSN 1932-6203

تفاصيل العنوان