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Academic Journal

Motif-VI loop acts as a nucleotide valve in the West Nile Virus NS3 Helicase.

Authors : Roy P; Department of Chemistry, Oklahoma State University, Stillwater, OK 74078, USA.; Walter Z

Subjects: Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/metabolism ; Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/chemistry ; Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/genetics

Source: Nucleic acids research [Nucleic Acids Res] 2024 Jul 22; Vol. 52 (13), pp. 7447-7464.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

The interaction of Orthoflavivirus nonstructural proteins 3 and 5 with human fatty acid synthase.

Authors : Sornprasert S; Institute of Molecular Biosciences, Mahidol University, Salaya, Thailand.; Sornjai W

Subjects: Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/metabolism ; Fatty Acid Synthase, Type I*/Fatty Acid Synthase, Type I*/Fatty Acid Synthase, Type I*/metabolism ; Serine Endopeptidases*/Serine Endopeptidases*/Serine Endopeptidases*/metabolism

Source: PloS one [PLoS One] 2025 Mar 25; Vol. 20 (3), pp. e0319207. Date of Electronic Publication: 2025 Mar 25 (Print Publication: 2025).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Enhancing HCV NS3 Inhibitor Classification with Optimized Molecular Fingerprints Using Random Forest.

Authors : Atasever S; Department of Computer Engineering, Faculty of Engineering and Architecture, Nevsehir Haci Bektas Veli University, 50300 Nevşehir, Turkey.

Subjects: Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/antagonists & inhibitors ; Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/chemistry ; Antiviral Agents*/Antiviral Agents*/Antiviral Agents*/chemistry

Source: International journal of molecular sciences [Int J Mol Sci] 2025 Mar 17; Vol. 26 (6). Date of Electronic Publication: 2025 Mar 17.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

TRIM38 Inhibits Zika Virus by Upregulating RIG-I/MDA5 Pathway and Promoting Ubiquitin-Mediated Degradation of Viral NS3 Protein.

Authors : He J; Institute of Basic Medicine, North Sichuan Medical College, Nanchong 637100, China.; Kuang Y

Subjects: Zika Virus*/Zika Virus*/Zika Virus*/physiology ; Zika Virus*/Zika Virus*/Zika Virus*/immunology ; Zika Virus*/Zika Virus*/Zika Virus*/genetics

Source: Viruses [Viruses] 2025 Jan 30; Vol. 17 (2). Date of Electronic Publication: 2025 Jan 30.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915

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Academic Journal

A novel ADP-directed chaperone function facilitates the ATP-driven motor activity of SARS-CoV helicase.

Authors : Yu J; Single-Molecule and Cell Mechanobiology Laboratory, Daejeon, 34141, South Korea.; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, 34141, South Korea.

Subjects: Adenosine Triphosphate*/Adenosine Triphosphate*/Adenosine Triphosphate*/metabolism ; Adenosine Diphosphate*/Adenosine Diphosphate*/Adenosine Diphosphate*/metabolism ; Molecular Chaperones*/Molecular Chaperones*/Molecular Chaperones*/metabolism

Source: Nucleic acids research [Nucleic Acids Res] 2025 Jan 24; Vol. 53 (3).Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

NS2B-D55E and NS2B-E65D Variations Are Responsible for Differences in NS2B-NS3 Protease Activities Between Japanese Encephalitis Virus Genotype I and III in Fluorogenic Peptide Model.

Authors : Wahaab A; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.; The Department of Entomology, Center for Infectious Disease Dynamics, and the Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802, USA.

Subjects: Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/genetics ; Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/metabolism ; Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/chemistry

Source: International journal of molecular sciences [Int J Mol Sci] 2024 Nov 26; Vol. 25 (23). Date of Electronic Publication: 2024 Nov 26.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Tertiary Structures of Haseki Tick Virus Nonstructural Proteins Are Similar to Those of Orthoflaviviruses .

Authors : Gladysheva A; State Research Center of Virology and Biotechnology 'Vector', 630559 Kol'tsovo, Russia.; Osinkina I

Subjects: Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/chemistry ; Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/genetics ; Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/metabolism

Source: International journal of molecular sciences [Int J Mol Sci] 2024 Dec 20; Vol. 25 (24). Date of Electronic Publication: 2024 Dec 20.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Identifying Allosteric Small-Molecule Binding Sites of Inactive NS2B-NS3 Proteases of Pathogenic Flaviviridae .

Authors : Grabski H; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, San Diego, CA 92093-0657, USA.; L.A. Orbeli Institute of Physiology, National Academy of Sciences, Yerevan 0028, Armenia.

Subjects: Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/chemistry ; Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/metabolism ; Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/genetics

Source: Viruses [Viruses] 2024 Dec 24; Vol. 17 (1). Date of Electronic Publication: 2024 Dec 24.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915

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Academic Journal

Membrane Retention of West Nile Virus NS5 Depends on NS1 or NS3 for Enzymatic Activity.

Authors : Tseng AC; Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, USA.; Molecular Biosciences and Bioengineering Graduate Program, College of Tropical Agriculture and Human Resources, University of Hawaii at Manoa, Honolulu, HI 96822, USA.

Subjects: Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/metabolism ; Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/genetics ; West Nile virus*/West Nile virus*/West Nile virus*/enzymology

Source: Viruses [Viruses] 2024 Aug 16; Vol. 16 (8). Date of Electronic Publication: 2024 Aug 16.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915

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Academic Journal

Elucidating the inhibitory mechanism of Zika virus NS2B-NS3 protease with dipeptide inhibitors: Insights from molecular docking and molecular dynamics simulations.

Authors : Ullah S; S-Khan Lab, Mardan, Khyber Pakhtunkhwa, Pakistan.; Ullah F

Subjects: Zika Virus*/Zika Virus*/Zika Virus*/enzymology ; Zika Virus*/Zika Virus*/Zika Virus*/drug effects ; Molecular Docking Simulation*

Source: PloS one [PLoS One] 2024 Aug 08; Vol. 19 (8), pp. e0307902. Date of Electronic Publication: 2024 Aug 08 (Print Publication: 2024).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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نتائج البحث

فلترة النتائج

Motif-VI loop acts as a nucleotide valve in the West Nile Virus NS3 Helicase.

The interaction of Orthoflavivirus nonstructural proteins 3 and 5 with human fatty acid synthase.

Enhancing HCV NS3 Inhibitor Classification with Optimized Molecular Fingerprints Using Random Forest.

TRIM38 Inhibits Zika Virus by Upregulating RIG-I/MDA5 Pathway and Promoting Ubiquitin-Mediated Degradation of Viral NS3 Protein.

A novel ADP-directed chaperone function facilitates the ATP-driven motor activity of SARS-CoV helicase.

NS2B-D55E and NS2B-E65D Variations Are Responsible for Differences in NS2B-NS3 Protease Activities Between Japanese Encephalitis Virus Genotype I and III in Fluorogenic Peptide Model.

Tertiary Structures of Haseki Tick Virus Nonstructural Proteins Are Similar to Those of Orthoflaviviruses .

Identifying Allosteric Small-Molecule Binding Sites of Inactive NS2B-NS3 Proteases of Pathogenic Flaviviridae .

Membrane Retention of West Nile Virus NS5 Depends on NS1 or NS3 for Enzymatic Activity.

Elucidating the inhibitory mechanism of Zika virus NS2B-NS3 protease with dipeptide inhibitors: Insights from molecular docking and molecular dynamics simulations.

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