نتائج البحث

PLCβ1-SHP-2 complex, PLCβ1 tyrosine dephosphorylation and SHP-2 phosphatase activity: a new part of Angiotensin II signaling?

• Authors : Calò LA; Department of Clinical and Experimental Medicine, Clinica Medica University of Padova, School of Medicine, Italy. ; Bordin L

Subjects: Signal Transduction*; Angiotensin II/Angiotensin II/Angiotensin II/*metabolism ; Phospholipase C beta/Phospholipase C beta/Phospholipase C beta/*metabolism

• Source: Journal of biomedical science [J Biomed Sci] 2011 Jun 13; Vol. 18, pp. 38. Date of Electronic Publication: 2011 Jun 13.Publisher: BioMed Central Country of Publication: England NLM ID: 9421567 Publication Model: Electronic Cited Medium: Internet ISSN: 1423-0127

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Interaction of SHP-2 SH2 domains with PD-1 ITSM induces PD-1 dimerization and SHP-2 activation.

• Authors : Patsoukis, Nikolaos^1,2; Duke-Cohan, Jonathan S.³; Chaudhri, Apoorvi^3,4

• Source: Communications Biology. 3/17/2020, Vol. 3 Issue 1, p1-13. 13p.

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Tyr66 acts as a conformational switch in the closed-to-open transition of the SHP-2 N-SH2-domain phosphotyrosine-peptide binding cleft.

• Authors : Guvench O; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, HSF II-629, Baltimore, MD 21201, USA. ; Qu CK

Subjects: Tyrosine*; Protein Tyrosine Phosphatases/Protein Tyrosine Phosphatases/Protein Tyrosine Phosphatases/*chemistry; Computer Simulation

• Source: BMC structural biology [BMC Struct Biol] 2007 Mar 22; Vol. 7, pp. 14. Date of Electronic Publication: 2007 Mar 22.Publisher: BioMed Central Country of Publication: England NLM ID: 101088689 Publication Model: Electronic Cited Medium: Internet ISSN: 1472-6807

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SHP-2 is involved in heterodimer specific loss of phosphorylation of Tyr771 in the PDGF beta-receptor.

• Authors : Ekman S; Ludwig Institute for Cancer Research, Biomedical Center, Box 595, S-751 24, Uppsala, Sweden.; Kallin A

Subjects: Protein Tyrosine Phosphatases/Protein Tyrosine Phosphatases/Protein Tyrosine Phosphatases/*metabolism ; Receptor, Platelet-Derived Growth Factor beta/Receptor, Platelet-Derived Growth Factor beta/Receptor, Platelet-Derived Growth Factor beta/*metabolism ; Tyrosine/Tyrosine/Tyrosine/*metabolism

• Source: Oncogene [Oncogene] 2002 Mar 14; Vol. 21 (12), pp. 1870-5.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print Cited Medium: Print ISSN: 0950-9232

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SHP-2 binds to Tyr763 and Tyr1009 in the PDGF beta-receptor and mediates PDGF-induced activation of the Ras/MAP kinase pathway and chemotaxis.

• Authors : Rönnstrand L; Ludwig Institute for Cancer Research, Biomedical Centre, Uppsala, Sweden.; Arvidsson AK

Subjects: Chemotaxis* ; Protein Processing, Post-Translational* ; Signal Transduction*

• Source: Oncogene [Oncogene] 1999 Jun 24; Vol. 18 (25), pp. 3696-702.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print Cited Medium: Print ISSN: 0950-9232

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Tyrosine phosphatase SHP-2 is a mediator of activity-dependent neuronal excitotoxicity.

• Authors : Rusanescu, Gabriel¹; Yang, Wentian²; Bai, Ailin²

Subjects: *PROTEIN-tyrosine phosphatase; *NEURODEGENERATION; *NEURONS

• Source: EMBO Journal. 1/26/2005, Vol. 24 Issue 2, p305-314. 10p.

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Interaction of SHP-2 SH2 domains with PD-1 ITSM induces PD-1 dimerization and SHP-2 activation

• Authors : Anders H. Berg; Vassiliki A. Boussiotis; Jonathan S. Duke-Cohan

Subjects: 0301 basic medicine; animal structures; T-Lymphocytes

• Source: Communications Biology, Vol 3, Iss 1, Pp 1-13 (2020)Communications Biology

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Siglec-6 Signaling Uses Src Kinase Tyrosine Phosphorylation and SHP-2 Recruitment

• Authors : Adrianne L. Stefanski; Michael D. Renecle; Anita Kramer

Subjects: Sialic Acid Binding Immunoglobulin-like Lectins; Placenta; Protein Tyrosine Phosphatase, Non-Receptor Type 6

• Source: Cells; Volume 11; Issue 21; Pages: 3427

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Calpain-dependent cleavage of SHP-1 and SHP-2 is involved in the dephosphorylation of Jurkat T cells induced by Entamoeba histolytica.

• Authors : KIM, K. A.¹; LEE, Y. A.¹; SHIN, M. H.¹

• Source: Parasite Immunology. Mar2010, Vol. 32 Issue 3, p176-183. 8p. 4 Black and White Photographs.

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SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levels.

• Authors : Lorenz, Ulrike¹

• Source: Immunological Reviews. Mar2009, Vol. 228 Issue 1, p342-359. 18p. 2 Diagrams.

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