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Intravenous Administration Is an Effective and Safe Route for Cancer Gene Therapy Using the Bifidobacterium-Mediated Recombinant HSV-1 Thymidine Kinase and Ganciclovir.

• Authors : Huicong Zhou¹ ; Changdong Wang¹ ; Tingting Xie¹

Subjects: *GENE therapy; *BIFIDOBACTERIUM; *THYMIDINE

• Source: International Journal of Molecular Sciences. Jun2016, Vol. 17 Issue 6, p891. 19p. 1 Diagram, 1 Chart, 7 Graphs.

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Mechanism of ganciclovir uptake by rabbit retina and human retinal pigmented epithelium cell line ARPE-19.

• Authors : Majumdar, Soumyajit¹; Macha, Sreeraj^1,2; Pal, Dhananjay¹

• Source: Current Eye Research. Aug/Sep2004, Vol. 29 Issue 2/3, p127-136. 10p.

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Neural differentiation of glioblastoma cell lines via a herpes simplex virus thymidine kinase/ganciclovir system driven by a glial fibrillary acidic protein promoter.

• Authors : Luo, Elizabeth Wei-Chia^1,2 (AUTHOR); Liao, Meng-Lin^1,3 (AUTHOR) ; Chien, Chung-Liang¹ (AUTHOR)

Subjects: *GLIAL fibrillary acidic protein; *HERPES simplex virus; *CELL differentiation

• Source: PLoS ONE. 8/9/2021, Vol. 16 Issue 8, p1-22. 22p.

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Inhibitory effects of the ultrasound-targeted microbubble destruction-mediated herpes simplex virus-thymidine kinase/ganciclovir system on ovarian cancer in mice.

• Authors : XIAN-LONG ZHOU¹; YU-LU SHI²; XIONG LI³

• Source: Experimental & Therapeutic Medicine. 2014, Vol. 8 Issue 4, p1159-1163. 5p.

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Cytogenetic genotoxicity of anti-herpes purine nucleoside analogues in CHO cells expressing the thymidine kinase gene of herpes simplex virus type 1: comparison of ganciclovir, penciclovir and aciclovir.

• Authors : Thust, R. ; Tomicic, M.; Klöcking, R.

Subjects: *CYTOGENETICS; *GENETIC toxicology; *THYMIDINE

• Source: Mutagenesis. Mar2000, Vol. 15 Issue 2, p177-184. 8p.

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Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/5-fluorocytosine suicide gene therapy-induced cell death in glioma cells.

• Authors : Fischer, Ute^1,2; Steffens, Sabine²; Frank, Susanne²

• Source: Oncogene. 2/10/2005, Vol. 24 Issue 7, p1231-1243. 13p.

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Superior cytostatic activity of the ganciclovir elaidic acid ester due to the prolonged intracellular retention of ganciclovir anabolites in herpes simplex virus type 1 thymidine kinase gene-transfected tumor cells.

• Authors : Balzarini, J; Degrève, B; Andrei, G

• Source: Gene Therapy. Mar1998, Vol. 5 Issue 3, p419. 8p.

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Different efficacy of in vivo herpes simplex virus thymidine kinase gene transduction and ganciclovir treatment on the inhibition of tumor growth of murine and human melanoma cells and rat glioblastoma cells.

• Authors : Berenstein, Mariana; Adris, Soraya; Ledda, Fernanda

• Source: Cancer Gene Therapy. Jul99, Vol. 6 Issue 4, p358. 9p.

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Substrate specificity and molecular modelling of the feline herpesvirus-1 thymidine kinase.

• Authors : Hussein IT; Department of Veterinary Medicine, Cambridge University, Cambridge, UK.; Miguel RN

Subjects: Thymidine/Thymidine/Thymidine/*metabolism ; Thymidine Kinase/Thymidine Kinase/Thymidine Kinase/*chemistry ; Thymidine Kinase/Thymidine Kinase/Thymidine Kinase/*metabolism

• Source: Archives of virology [Arch Virol] 2008; Vol. 153 (3), pp. 495-505. Date of Electronic Publication: 2008 Jan 15.Publisher: Springer-Verlag Country of Publication: Austria NLM ID: 7506870 Publication Model: Print-Electronic Cited Medium: Print ISSN:

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MLH1 deficiency enhances tumor cell sensitivity to ganciclovir.

• Authors : O'Konek, J. J.¹; Boucher, P. D.¹; Iacco, A. A.²

• Source: Cancer Gene Therapy. Sep2009, Vol. 16 Issue 9, p683-692. 10p. 1 Chart, 5 Graphs.

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