نتائج البحث

Thalidomide and its metabolite 5-hydroxythalidomide induce teratogenicity via the cereblon neosubstrate PLZF.

• Authors : Yamanaka S; Division of Cell-Free Sciences, Proteo-Science Center, Ehime University, Matsuyama, Japan.; Murai H

Subjects: Teratogenesis*; Adaptor Proteins, Signal Transducing/Adaptor Proteins, Signal Transducing/Adaptor Proteins, Signal Transducing/*metabolism ; Cytochrome P-450 CYP3A/Cytochrome P-450 CYP3A/Cytochrome P-450 CYP3A/*metabolism

• Source: The EMBO journal [EMBO J] 2021 Feb 15; Vol. 40 (4), pp. e105375. Date of Electronic Publication: 2021 Jan 20.Publisher: Wiley Blackwell Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Augmentation of Pectoral Fin Teratogenicity by Thalidomide in Human Cytochrome P450 3A-Expressing Zebrafish.

• Authors : Dong, Wenjing¹ (AUTHOR); Akasaka, Ippo¹ (AUTHOR); Komiyama, Akifumi¹ (AUTHOR)

• Source: Pharmaceuticals (14248247). Mar2023, Vol. 16 Issue 3, p368. 13p.

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Augmentation of Pectoral Fin Teratogenicity by Thalidomide in Human Cytochrome P450 3A-Expressing Zebrafish

• Authors : Wenjing Dong; Ippo Akasaka; Akifumi Komiyama

Subjects: CYP1A1; CYP3A4; CYP3A7

• Source: Pharmaceuticals, Vol 16, Iss 3, p 368 (2023)

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Recent advances in the molecular mechanism of thalidomide teratogenicity

• Authors : Shaobing Gao; Shichao Wang; Ruihua Fan

Subjects: Thalidomide; Teratogenicity; CRL4CRBN

• Source: Biomedicine & Pharmacotherapy, Vol 127, Iss , Pp 110114- (2020)

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Identification of a primary target of thalidomide teratogenicity.

• Authors : Ito T; Integrated Research Institute, Tokyo Institute of Technology, Yokohama 226-8503, Japan.; Ando H

Subjects: DNA-Binding Proteins/DNA-Binding Proteins/DNA-Binding Proteins/*metabolism ; Peptide Hydrolases/Peptide Hydrolases/Peptide Hydrolases/*metabolism ; Teratogens/Teratogens/Teratogens/*toxicity

• Source: Science (New York, N.Y.) [Science] 2010 Mar 12; Vol. 327 (5971), pp. 1345-50.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium:

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Mechanisms of thalidomide teratogenicity.

• Authors : Guenzler V

Subjects: T-Box Domain Proteins*; Bone and Bones/Bone and Bones/Bone and Bones/*drug effects ; Teratogens/Teratogens/Teratogens/*pharmacology

• Source: Nature medicine [Nat Med] 1999 Aug; Vol. 5 (8), pp. 853.Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print Cited Medium: Print ISSN:

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Free radical-mediated oxidative DNA damage in the mechanism of thalidomide teratogenicity.

• Authors : Parman T; Faculty of Pharmacy, University of Toronto, Ontario, Canada.; Wiley MJ

Subjects: DNA Damage*; Embryo, Mammalian/Embryo, Mammalian/Embryo, Mammalian/*metabolism ; Hypnotics and Sedatives/Hypnotics and Sedatives/Hypnotics and Sedatives/*metabolism

• Source: Nature medicine [Nat Med] 1999 May; Vol. 5 (5), pp. 582-5.Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print Cited Medium: Print ISSN:

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Phthalimide Derivative Shows Anti-angiogenic Activity in a 3D Microfluidic Model and No Teratogenicity in Zebrafish Embryos

• Authors : Annalisa Mercurio; Lucy Sharples; Filomena Corbo

Subjects: angiogenesis; 3D microfluidics; phthalimide derivative

• Source: Frontiers in Pharmacology, Vol 10 (2019)

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Genetic Susceptibility to Drug Teratogenicity: A Systematic Literature Review

• Authors : Julia do Amaral Gomes; Emilie Willoch Olstad; Thayne Woycinck Kowalski

Subjects: teratogens; prenatal exposures; pregnancy

• Source: Frontiers in Genetics, Vol 12 (2021)

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Phthalimide Derivative Shows Anti-angiogenic Activity in a 3D Microfluidic Model and No Teratogenicity in Zebrafish Embryos

• Authors : Mercurio A.; Sharples L.; Corbo F. ...

Subjects: 3D microfluidic; Angiogenesi; Phthalimide derivative

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