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Subject : tdp-43

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Academic Journal

Mining Disaggregase Sequence Space to Safely Counter TDP-43, FUS, and α-Synuclein Proteotoxicity

Authors : Tariq, Amber; Lin, JiaBei; Jackrel, Meredith E

Subjects: Biochemistry and Cell Biology; Biological Sciences; Neurodegenerative

Source: Cell Reports. 28(8)

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Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death

Authors : Gasset-Rosa, Fatima; Lu, Shan; Yu, Haiyang

Subjects: Acquired Cognitive Impairment; Neurodegenerative; Brain Disorders

Source: Neuron. 102(2)

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Nuclear import receptors are recruited by FG-nucleoporins to rescue hallmarks of TDP-43 proteinopathy

Authors : Khalil, Bilal; Chhangani, Deepak; Wren, Melissa C

Subjects: Science & Technology; Life Sciences & Biomedicine; Neurosciences

Source: Molecular Neurodegeneration , 17 , Article 80. (2022)

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Nuclear import receptors directly bind to arginine-rich dipeptide repeat proteins and suppress their pathological interactions

Authors : Hutten, Saskia; Usluer, Sinem; Bourgeois, Benjamin

Subjects: Department of Quantitative Biomedicine; 610 Medicine & health; General Biochemistry

Source: Hutten, Saskia; Usluer, Sinem; Bourgeois, Benjamin; Simonetti, Francesca; Odeh, Hana M; Fare, Charlotte M; Czuppa, Mareike; Hruska-Plochan, Marian; Hofweber, Mario; Polymenidou, Magdalini;

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Nuclear-import receptors as gatekeepers of pathological phase transitions in ALS/FTD.

Authors : Khalil, Bilal; Linsenmeier, Miriam; Smith, Courtney L.

Subjects: AMYOTROPHIC lateral sclerosis; PHASE transitions; NUCLEAR transport (Cytology)

Source: Molecular Neurodegeneration; 1/22/2024, Vol. 19 Issue 1, p1-29, 29p

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Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization

Authors : McGurk, Leeanne; Gomes, Edward; Guo, Lin

Subjects: ALS; amyotrophic lateral sclerosis; motor neuron disease

Source: McGurk , L , Gomes , E , Guo , L , Mojsilovic-Petrovic , J , Tran , V , Kalb , R G , Shorter , J & Bonini , N M 2018 , ' Poly(ADP-Ribose) Prevents Pathological Phase

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