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CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity

Subjects: 0301 basic medicine; General Science & Technology; 1.1 Normal biological development and functioning

  • Source: Science (New York, N.Y.), vol 360, iss 6387Chen, Janice S; Ma, Enbo; Harrington, Lucas B; Da Costa, Maria; Tian, Xinran; Palefsky, Joel M; et al.(2018). CRISPR-Cas12a target binding unleashes

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UbaLAI is a monomeric Type IIE restriction enzyme

Subjects: Models, Molecular; 0301 basic medicine; Protein domain

  • Source: Nucleic acids research, Oxford : Oxford University Press, 2017, Vol. 45, Iss. 16, p. 9583-9594Nucleic Acids ResearchNucleic acids research 45(16), 9583-9594 (2017). doi:10.1093/nar/gkx634

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